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Cognitive performance in nondemented nonpsychotic Parkinson disease patients with or without a history of depression prior to the onset of motor symptoms.
J Geriatr Psychiatry Neurol. 2010 Mar; 23(1):15-26.JG

Abstract

In Parkinson disease (PD), cognitive impairment is common, occurs mainly in the form of milder deficits (as opposed to dementia), and commonly coincides with depression. In this cross-sectional study, we evaluated whether depression that existed before the onset of typical motor symptoms (pre-PD depression) reflected on the actual cognitive performance. Nondemented nonpsychotic PD patients with (test, n = 27) and without (control, n = 112) a history of pre-PD depression, caliper-matched for age, education, and disease duration were assessed for motor and nonmotor disease characteristics and in a battery of cognitive tests. Test patients had higher actual depression/anxiety levels. Gradual multivariate and mediation analysis indicated unfavorable effects of pre-PD depression on cognition: a direct effect on mental set shifting/response inhibition (independent of actual depression/ anxiety or other factors); and indirect effects on other cognitive domains mediated through the increased depression/anxiety. Data suggest that pre-PD depression favors poorer cognitive abilities in nondemented patients at a given time after PD has been diagnosed.

Authors+Show Affiliations

Department of Neurology, University Hospital Centre Zagreb, Zagreb University School of Medicine, Zagreb, Croatia.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19996416

Citation

Klepac, Natasa, et al. "Cognitive Performance in Nondemented Nonpsychotic Parkinson Disease Patients With or Without a History of Depression Prior to the Onset of Motor Symptoms." Journal of Geriatric Psychiatry and Neurology, vol. 23, no. 1, 2010, pp. 15-26.
Klepac N, Hajnsek S, Trkulja V. Cognitive performance in nondemented nonpsychotic Parkinson disease patients with or without a history of depression prior to the onset of motor symptoms. J Geriatr Psychiatry Neurol. 2010;23(1):15-26.
Klepac, N., Hajnsek, S., & Trkulja, V. (2010). Cognitive performance in nondemented nonpsychotic Parkinson disease patients with or without a history of depression prior to the onset of motor symptoms. Journal of Geriatric Psychiatry and Neurology, 23(1), 15-26. https://doi.org/10.1177/0891988709351831
Klepac N, Hajnsek S, Trkulja V. Cognitive Performance in Nondemented Nonpsychotic Parkinson Disease Patients With or Without a History of Depression Prior to the Onset of Motor Symptoms. J Geriatr Psychiatry Neurol. 2010;23(1):15-26. PubMed PMID: 19996416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive performance in nondemented nonpsychotic Parkinson disease patients with or without a history of depression prior to the onset of motor symptoms. AU - Klepac,Natasa, AU - Hajnsek,Sanja, AU - Trkulja,Vladimir, Y1 - 2009/12/08/ PY - 2009/12/10/entrez PY - 2009/12/10/pubmed PY - 2010/5/12/medline SP - 15 EP - 26 JF - Journal of geriatric psychiatry and neurology JO - J Geriatr Psychiatry Neurol VL - 23 IS - 1 N2 - In Parkinson disease (PD), cognitive impairment is common, occurs mainly in the form of milder deficits (as opposed to dementia), and commonly coincides with depression. In this cross-sectional study, we evaluated whether depression that existed before the onset of typical motor symptoms (pre-PD depression) reflected on the actual cognitive performance. Nondemented nonpsychotic PD patients with (test, n = 27) and without (control, n = 112) a history of pre-PD depression, caliper-matched for age, education, and disease duration were assessed for motor and nonmotor disease characteristics and in a battery of cognitive tests. Test patients had higher actual depression/anxiety levels. Gradual multivariate and mediation analysis indicated unfavorable effects of pre-PD depression on cognition: a direct effect on mental set shifting/response inhibition (independent of actual depression/ anxiety or other factors); and indirect effects on other cognitive domains mediated through the increased depression/anxiety. Data suggest that pre-PD depression favors poorer cognitive abilities in nondemented patients at a given time after PD has been diagnosed. SN - 0891-9887 UR - https://www.unboundmedicine.com/medline/citation/19996416/Cognitive_performance_in_nondemented_nonpsychotic_Parkinson_disease_patients_with_or_without_a_history_of_depression_prior_to_the_onset_of_motor_symptoms_ L2 - https://journals.sagepub.com/doi/10.1177/0891988709351831?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -