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Anthropometric indices as determinants of haemorheological cardiovascular disease risk factors in Nigerian adults living in a semi-urban community.
Clin Hemorheol Microcirc 2009; 43(4):335-44CH

Abstract

BACKGROUND

Some epidemiological studies have found anthropometric indices to be related to cardiovascular disease risk factors. Fibrinogen--an acute phase reactant protein--is central in the haemostatic system. Its associations with cardiovascular diseases have been well documented. A possible association between measures of body fat and fibrinogen has been reported.

AIMS

To study the relationship of fibrinogen (PFC), plasma viscosity (PV) and haematocrit (HCT) with measures of obesity (body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR)) in apparently healthy Nigerians living in Ilisan-Remo, a semi-urban community.

SUBJECTS AND METHODS

The study population comprised of apparently healthy mono-ethnic Nigerians living in Ilisan-Remo town. Obesity was measured using the body mass index, waist circumference, waist-to-hip ratio and waist-to-height ratio. Blood samples were analyzed for rheological parameters (plasma fibrinogen, plasma viscosity, haematocrit and the erythrocyte sedimentation rate (ESR) using standard methods.

RESULTS

A total of 122 subjects were studied, 46 males (mean age 57+/-15.7 years) and 76 females (mean age 58.92+/-17.99 years). The mean systolic blood pressure was 138.5 mmHg for males and 135.2 mmHg for females respectively. The independent variables (BMI, waist-to-hip ratio) were divided into 2 groups using the 75th percentile cut off. In the BMI group, the diastolic blood pressure, haematocrit and plasma viscosity were significantly higher in males (p<0.0001) in the >75th percentile group but not in females. Using the waist circumference; plasma viscosity and diastolic blood pressure were higher in males (p<0.0001) in the >75th percentile group. In females the haematocrit and blood viscosity were significantly higher (p=0.0074, p=0.0434) respectively in the >75th percentile group. Using stepwise multiple regression analysis, the waist circumference and BMI were found to be significant determinant for systolic and diastolic blood pressure. The BMI was significant determinant for the haemorheological cardiovascular disease (HCVD) risk factors except fibrinogen. While the waist circumference was a significant predictor of all the haemorheological cardiovascular disease risk factors (p<0.0001).

CONCLUSION

While the BMI and the WHR may be good predictors of CVD (cardiovascular disease) risk factors, we have shown that the waist circumference may be a better predictor of haemorheological cardiovascular disease risk factors than the BMI in Nigerians.

Authors+Show Affiliations

Department of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, Nigeria.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19996522

Citation

Famodu, A A., and O A. Awodu. "Anthropometric Indices as Determinants of Haemorheological Cardiovascular Disease Risk Factors in Nigerian Adults Living in a Semi-urban Community." Clinical Hemorheology and Microcirculation, vol. 43, no. 4, 2009, pp. 335-44.
Famodu AA, Awodu OA. Anthropometric indices as determinants of haemorheological cardiovascular disease risk factors in Nigerian adults living in a semi-urban community. Clin Hemorheol Microcirc. 2009;43(4):335-44.
Famodu, A. A., & Awodu, O. A. (2009). Anthropometric indices as determinants of haemorheological cardiovascular disease risk factors in Nigerian adults living in a semi-urban community. Clinical Hemorheology and Microcirculation, 43(4), pp. 335-44. doi:10.3233/CH-2009-1244.
Famodu AA, Awodu OA. Anthropometric Indices as Determinants of Haemorheological Cardiovascular Disease Risk Factors in Nigerian Adults Living in a Semi-urban Community. Clin Hemorheol Microcirc. 2009;43(4):335-44. PubMed PMID: 19996522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anthropometric indices as determinants of haemorheological cardiovascular disease risk factors in Nigerian adults living in a semi-urban community. AU - Famodu,A A, AU - Awodu,O A, PY - 2009/12/10/entrez PY - 2009/12/10/pubmed PY - 2010/5/12/medline SP - 335 EP - 44 JF - Clinical hemorheology and microcirculation JO - Clin. Hemorheol. Microcirc. VL - 43 IS - 4 N2 - BACKGROUND: Some epidemiological studies have found anthropometric indices to be related to cardiovascular disease risk factors. Fibrinogen--an acute phase reactant protein--is central in the haemostatic system. Its associations with cardiovascular diseases have been well documented. A possible association between measures of body fat and fibrinogen has been reported. AIMS: To study the relationship of fibrinogen (PFC), plasma viscosity (PV) and haematocrit (HCT) with measures of obesity (body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR)) in apparently healthy Nigerians living in Ilisan-Remo, a semi-urban community. SUBJECTS AND METHODS: The study population comprised of apparently healthy mono-ethnic Nigerians living in Ilisan-Remo town. Obesity was measured using the body mass index, waist circumference, waist-to-hip ratio and waist-to-height ratio. Blood samples were analyzed for rheological parameters (plasma fibrinogen, plasma viscosity, haematocrit and the erythrocyte sedimentation rate (ESR) using standard methods. RESULTS: A total of 122 subjects were studied, 46 males (mean age 57+/-15.7 years) and 76 females (mean age 58.92+/-17.99 years). The mean systolic blood pressure was 138.5 mmHg for males and 135.2 mmHg for females respectively. The independent variables (BMI, waist-to-hip ratio) were divided into 2 groups using the 75th percentile cut off. In the BMI group, the diastolic blood pressure, haematocrit and plasma viscosity were significantly higher in males (p<0.0001) in the >75th percentile group but not in females. Using the waist circumference; plasma viscosity and diastolic blood pressure were higher in males (p<0.0001) in the >75th percentile group. In females the haematocrit and blood viscosity were significantly higher (p=0.0074, p=0.0434) respectively in the >75th percentile group. Using stepwise multiple regression analysis, the waist circumference and BMI were found to be significant determinant for systolic and diastolic blood pressure. The BMI was significant determinant for the haemorheological cardiovascular disease (HCVD) risk factors except fibrinogen. While the waist circumference was a significant predictor of all the haemorheological cardiovascular disease risk factors (p<0.0001). CONCLUSION: While the BMI and the WHR may be good predictors of CVD (cardiovascular disease) risk factors, we have shown that the waist circumference may be a better predictor of haemorheological cardiovascular disease risk factors than the BMI in Nigerians. SN - 1875-8622 UR - https://www.unboundmedicine.com/medline/citation/19996522/Anthropometric_indices_as_determinants_of_haemorheological_cardiovascular_disease_risk_factors_in_Nigerian_adults_living_in_a_semi_urban_community_ L2 - https://content.iospress.com/openurl?genre=article&amp;issn=1386-0291&amp;volume=43&amp;issue=4&amp;spage=335 DB - PRIME DP - Unbound Medicine ER -