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Inhibition of fluorouracil-induced stomatitis by oral cryotherapy.
J Clin Oncol 1991; 9(3):449-52JC

Abstract

Mucositis is a significant dose-limiting toxicity associated with fluorouracil (5FU), particularly when it is combined with leucovorin. We hypothesized that oral cryotherapy would cause local vasoconstriction and would temporarily decrease blood flow to the oral mucous membranes. If cryotherapy were used during the time of peak serum 5FU levels, then the oral mucous membranes would have less exposure to 5FU and thus develop less mucositis. To test this hypothesis, 95 patients scheduled to receive their first cycle of 5FU plus leucovorin were randomized to have oral cryotherapy at the time of chemotherapy administration or to serve as a control group. Subsequent mucositis was significantly reduced in the group assigned to receive cryotherapy as judged by the attending physicians (P = .0002) and by the patients themselves (P = .0001). We now routinely recommend this cryotherapy procedure for our patients receiving daily bolus 5FU plus leucovorin.

Authors+Show Affiliations

Cedar Rapids Oncology Project, Iowa.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1999715

Citation

Mahood, D J., et al. "Inhibition of Fluorouracil-induced Stomatitis By Oral Cryotherapy." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, vol. 9, no. 3, 1991, pp. 449-52.
Mahood DJ, Dose AM, Loprinzi CL, et al. Inhibition of fluorouracil-induced stomatitis by oral cryotherapy. J Clin Oncol. 1991;9(3):449-52.
Mahood, D. J., Dose, A. M., Loprinzi, C. L., Veeder, M. H., Athmann, L. M., Therneau, T. M., ... Gusa, N. L. (1991). Inhibition of fluorouracil-induced stomatitis by oral cryotherapy. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 9(3), pp. 449-52.
Mahood DJ, et al. Inhibition of Fluorouracil-induced Stomatitis By Oral Cryotherapy. J Clin Oncol. 1991;9(3):449-52. PubMed PMID: 1999715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of fluorouracil-induced stomatitis by oral cryotherapy. A1 - Mahood,D J, AU - Dose,A M, AU - Loprinzi,C L, AU - Veeder,M H, AU - Athmann,L M, AU - Therneau,T M, AU - Sorensen,J M, AU - Gainey,D K, AU - Mailliard,J A, AU - Gusa,N L, PY - 1991/3/1/pubmed PY - 1991/3/1/medline PY - 1991/3/1/entrez SP - 449 EP - 52 JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology JO - J. Clin. Oncol. VL - 9 IS - 3 N2 - Mucositis is a significant dose-limiting toxicity associated with fluorouracil (5FU), particularly when it is combined with leucovorin. We hypothesized that oral cryotherapy would cause local vasoconstriction and would temporarily decrease blood flow to the oral mucous membranes. If cryotherapy were used during the time of peak serum 5FU levels, then the oral mucous membranes would have less exposure to 5FU and thus develop less mucositis. To test this hypothesis, 95 patients scheduled to receive their first cycle of 5FU plus leucovorin were randomized to have oral cryotherapy at the time of chemotherapy administration or to serve as a control group. Subsequent mucositis was significantly reduced in the group assigned to receive cryotherapy as judged by the attending physicians (P = .0002) and by the patients themselves (P = .0001). We now routinely recommend this cryotherapy procedure for our patients receiving daily bolus 5FU plus leucovorin. SN - 0732-183X UR - https://www.unboundmedicine.com/medline/citation/1999715/Inhibition_of_fluorouracil_induced_stomatitis_by_oral_cryotherapy_ L2 - http://ascopubs.org/doi/full/10.1200/JCO.1991.9.3.449?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -