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The effect of metformin treatment for 2 years without caloric restriction on endocrine and metabolic parameters in women with polycystic ovary syndrome.
Exp Clin Endocrinol Diabetes. 2010 Oct; 118(9):633-7.EC

Abstract

INTRODUCTION

The aim of this study was to evaluate long-term changes in endocrine and metabolic parameters and body mass index in women with polycystic ovary syndrome (PCOS) who were treated with metformin over 2 years without caloric restriction.

MATERIAL AND METHODS

Twenty-six obese women with PCOS were treated with metformin over 2 years without caloric restriction. Clinical, metabolic and endocrine parameters and the body mass index were measured and an oral glucose tolerance test was carried out to calculate insulin resistance indices at the beginning and at the follow-up after 2 years. The Homeostatic Model for Assessment of Insulin Resistance (HOMA-IR) was calculated.

RESULTS

No significant changes in body mass index or HOMA-IR were observed. However, a significant decrease in fasting and 2-h insulin levels was observed. Women showed a significant increase in sex hormone-binding globulin (SHBG) levels, while total testosterone (TT) levels and the free androgen index decreased significantly. Furthermore a significant decrease in hirsutism was observed. There was a decrease in cholesterol and an increase in high-density lipoprotein.

CONCLUSIONS

Long-term treatment with metformin in women with PCOS appears to reduce androgen excess due to increased SHBG and decreased TT levels resulting in improvement of hirsutism as a clinical sign of androgen excess. Furthermore a significant decrease in fasting and 2-h insulin levels and slightly improved insulin resistance indices were observed.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University Hospital Erlangen, Erlangen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19998243

Citation

Oppelt, P G., et al. "The Effect of Metformin Treatment for 2 Years Without Caloric Restriction On Endocrine and Metabolic Parameters in Women With Polycystic Ovary Syndrome." Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, vol. 118, no. 9, 2010, pp. 633-7.
Oppelt PG, Mueller A, Jentsch K, et al. The effect of metformin treatment for 2 years without caloric restriction on endocrine and metabolic parameters in women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes. 2010;118(9):633-7.
Oppelt, P. G., Mueller, A., Jentsch, K., Kronawitter, D., Reissmann, C., Dittrich, R., Beckmann, M. W., & Cupisti, S. (2010). The effect of metformin treatment for 2 years without caloric restriction on endocrine and metabolic parameters in women with polycystic ovary syndrome. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, 118(9), 633-7. https://doi.org/10.1055/s-0029-1237705
Oppelt PG, et al. The Effect of Metformin Treatment for 2 Years Without Caloric Restriction On Endocrine and Metabolic Parameters in Women With Polycystic Ovary Syndrome. Exp Clin Endocrinol Diabetes. 2010;118(9):633-7. PubMed PMID: 19998243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of metformin treatment for 2 years without caloric restriction on endocrine and metabolic parameters in women with polycystic ovary syndrome. AU - Oppelt,P G, AU - Mueller,A, AU - Jentsch,K, AU - Kronawitter,D, AU - Reissmann,C, AU - Dittrich,R, AU - Beckmann,M W, AU - Cupisti,S, Y1 - 2009/12/08/ PY - 2009/12/10/entrez PY - 2009/12/10/pubmed PY - 2011/2/3/medline SP - 633 EP - 7 JF - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association JO - Exp Clin Endocrinol Diabetes VL - 118 IS - 9 N2 - INTRODUCTION: The aim of this study was to evaluate long-term changes in endocrine and metabolic parameters and body mass index in women with polycystic ovary syndrome (PCOS) who were treated with metformin over 2 years without caloric restriction. MATERIAL AND METHODS: Twenty-six obese women with PCOS were treated with metformin over 2 years without caloric restriction. Clinical, metabolic and endocrine parameters and the body mass index were measured and an oral glucose tolerance test was carried out to calculate insulin resistance indices at the beginning and at the follow-up after 2 years. The Homeostatic Model for Assessment of Insulin Resistance (HOMA-IR) was calculated. RESULTS: No significant changes in body mass index or HOMA-IR were observed. However, a significant decrease in fasting and 2-h insulin levels was observed. Women showed a significant increase in sex hormone-binding globulin (SHBG) levels, while total testosterone (TT) levels and the free androgen index decreased significantly. Furthermore a significant decrease in hirsutism was observed. There was a decrease in cholesterol and an increase in high-density lipoprotein. CONCLUSIONS: Long-term treatment with metformin in women with PCOS appears to reduce androgen excess due to increased SHBG and decreased TT levels resulting in improvement of hirsutism as a clinical sign of androgen excess. Furthermore a significant decrease in fasting and 2-h insulin levels and slightly improved insulin resistance indices were observed. SN - 1439-3646 UR - https://www.unboundmedicine.com/medline/citation/19998243/The_effect_of_metformin_treatment_for_2_years_without_caloric_restriction_on_endocrine_and_metabolic_parameters_in_women_with_polycystic_ovary_syndrome_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0029-1237705 DB - PRIME DP - Unbound Medicine ER -