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Maternal diet during pregnancy and allergic sensitization in the offspring by 5 yrs of age: a prospective cohort study.
Pediatr Allergy Immunol. 2010 Feb; 21(1 Pt 1):29-37.PA

Abstract

To examine the effect of maternal diet during pregnancy on allergic sensitization in the offspring by 5 yrs of age. The Finnish type 1 Diabetes Prediction and Prevention Nutrition Study. A population-based cohort study with 5-yr follow-up. A total of 931 children with human leukocyte antigen-conferred susceptibility to type 1 diabetes for whom maternal pregnancy food frequency questionnaire data and allergen-specific immunoglobulin E measurement at 5 yrs were available. Increasing maternal consumption of citrus fruits [odds ratio (OR) = 1.14, 95% confidence interval (CI) = 1.05-1.25] and total fruit (OR = 1.36, 95% CI = 1.09-1.70) were positively associated with sensitization to inhalant allergens, after adjustment for potential confounders. Maternal intake of vitamin D (OR = 0.56, 95% CI = 0.35-0.91) was inversely associated with sensitization to food allergens. Maternal consumption of citrus fruits during pregnancy may increase the risk to allergic sensitization in the offspring, whereas vitamin D intake may have a beneficial effect. Further studies are required to define more closely the putative effect of maternal intake of polyunsaturated fatty acids on development of allergic diseases in the offspring.

Authors+Show Affiliations

Tampere School of Public Health, University of Tampere, Tampere, Finland. bright.nwaru@uta.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20003068

Citation

Nwaru, Bright I., et al. "Maternal Diet During Pregnancy and Allergic Sensitization in the Offspring By 5 Yrs of Age: a Prospective Cohort Study." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 21, no. 1 Pt 1, 2010, pp. 29-37.
Nwaru BI, Ahonen S, Kaila M, et al. Maternal diet during pregnancy and allergic sensitization in the offspring by 5 yrs of age: a prospective cohort study. Pediatr Allergy Immunol. 2010;21(1 Pt 1):29-37.
Nwaru, B. I., Ahonen, S., Kaila, M., Erkkola, M., Haapala, A. M., Kronberg-Kippilä, C., Veijola, R., Ilonen, J., Simell, O., Knip, M., & Virtanen, S. M. (2010). Maternal diet during pregnancy and allergic sensitization in the offspring by 5 yrs of age: a prospective cohort study. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 21(1 Pt 1), 29-37. https://doi.org/10.1111/j.1399-3038.2009.00949.x
Nwaru BI, et al. Maternal Diet During Pregnancy and Allergic Sensitization in the Offspring By 5 Yrs of Age: a Prospective Cohort Study. Pediatr Allergy Immunol. 2010;21(1 Pt 1):29-37. PubMed PMID: 20003068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal diet during pregnancy and allergic sensitization in the offspring by 5 yrs of age: a prospective cohort study. AU - Nwaru,Bright I, AU - Ahonen,Suvi, AU - Kaila,Minna, AU - Erkkola,Maijaliisa, AU - Haapala,Anna-Maija, AU - Kronberg-Kippilä,Carina, AU - Veijola,Riitta, AU - Ilonen,Jorma, AU - Simell,Olli, AU - Knip,Mikael, AU - Virtanen,Suvi M, Y1 - 2009/12/09/ PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/8/24/medline SP - 29 EP - 37 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 21 IS - 1 Pt 1 N2 - To examine the effect of maternal diet during pregnancy on allergic sensitization in the offspring by 5 yrs of age. The Finnish type 1 Diabetes Prediction and Prevention Nutrition Study. A population-based cohort study with 5-yr follow-up. A total of 931 children with human leukocyte antigen-conferred susceptibility to type 1 diabetes for whom maternal pregnancy food frequency questionnaire data and allergen-specific immunoglobulin E measurement at 5 yrs were available. Increasing maternal consumption of citrus fruits [odds ratio (OR) = 1.14, 95% confidence interval (CI) = 1.05-1.25] and total fruit (OR = 1.36, 95% CI = 1.09-1.70) were positively associated with sensitization to inhalant allergens, after adjustment for potential confounders. Maternal intake of vitamin D (OR = 0.56, 95% CI = 0.35-0.91) was inversely associated with sensitization to food allergens. Maternal consumption of citrus fruits during pregnancy may increase the risk to allergic sensitization in the offspring, whereas vitamin D intake may have a beneficial effect. Further studies are required to define more closely the putative effect of maternal intake of polyunsaturated fatty acids on development of allergic diseases in the offspring. SN - 1399-3038 UR - https://www.unboundmedicine.com/medline/citation/20003068/Maternal_diet_during_pregnancy_and_allergic_sensitization_in_the_offspring_by_5_yrs_of_age:_a_prospective_cohort_study_ L2 - https://doi.org/10.1111/j.1399-3038.2009.00949.x DB - PRIME DP - Unbound Medicine ER -