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Heightened central affective response to visceral sensations of pain and discomfort in IBS.
Neurogastroenterol Motil. 2010 Mar; 22(3):276-e80.NM

Abstract

BACKGROUND

Typically, conventional functional imaging methods involve repeated exposures to sensory stimulation. In rectal distension (RD) studies that involve multiple distensions, however, it is difficult to disambiguate the central response to RD from pathological alterations in peripheral neural responses associated with relaxation and accommodation of the rectum.

METHODS

This study addressed potential confounders found in previous imaging studies by collecting functional magnetic resonance imaging studies (fMRI) data during a single slow ramp-tonic distension paradigm and analysing fMRI signal changes using independent component analysis. KEY

RESULTS

Compared with controls, IBS participants showed increased activation of the anterior cingulate cortices, insula and ventral medial prefrontal regions suggesting heightened affective responses to painful visceral stimuli. In addition, the failure by IBS patients to down-regulate activity within ventral medial prefrontal and the posterior cingulate/precuneus regions was suggestive of reduced sensitivity to somatic changes and delayed shifts away from rest in ;default network' activity patterns. Controls showed heightened activation of the thalamus, striatal regions and dorsolateral prefrontal cortex suggesting greater arousal and salience-driven sustained attention reactions and greater modulation of affective responses to discomfort and pain. CONCLUSION&INFERENCES This work points to alterations in the central response to visceral pain and discomfort in IBS, highlighting diminished modulation and heightened internalization of affective reactions.

Authors+Show Affiliations

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada. hallg@mcmaster.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20003075

Citation

Hall, G B C., et al. "Heightened Central Affective Response to Visceral Sensations of Pain and Discomfort in IBS." Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, vol. 22, no. 3, 2010, pp. 276-e80.
Hall GB, Kamath MV, Collins S, et al. Heightened central affective response to visceral sensations of pain and discomfort in IBS. Neurogastroenterol Motil. 2010;22(3):276-e80.
Hall, G. B., Kamath, M. V., Collins, S., Ganguli, S., Spaziani, R., Miranda, K. L., Bayati, A., & Bienenstock, J. (2010). Heightened central affective response to visceral sensations of pain and discomfort in IBS. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, 22(3), 276-e80. https://doi.org/10.1111/j.1365-2982.2009.01436.x
Hall GB, et al. Heightened Central Affective Response to Visceral Sensations of Pain and Discomfort in IBS. Neurogastroenterol Motil. 2010;22(3):276-e80. PubMed PMID: 20003075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heightened central affective response to visceral sensations of pain and discomfort in IBS. AU - Hall,G B C, AU - Kamath,M V, AU - Collins,S, AU - Ganguli,S, AU - Spaziani,R, AU - Miranda,K L, AU - Bayati,A, AU - Bienenstock,J, Y1 - 2009/12/11/ PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/6/29/medline SP - 276 EP - e80 JF - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society JO - Neurogastroenterol Motil VL - 22 IS - 3 N2 - BACKGROUND Typically, conventional functional imaging methods involve repeated exposures to sensory stimulation. In rectal distension (RD) studies that involve multiple distensions, however, it is difficult to disambiguate the central response to RD from pathological alterations in peripheral neural responses associated with relaxation and accommodation of the rectum. METHODS This study addressed potential confounders found in previous imaging studies by collecting functional magnetic resonance imaging studies (fMRI) data during a single slow ramp-tonic distension paradigm and analysing fMRI signal changes using independent component analysis. KEY RESULTS Compared with controls, IBS participants showed increased activation of the anterior cingulate cortices, insula and ventral medial prefrontal regions suggesting heightened affective responses to painful visceral stimuli. In addition, the failure by IBS patients to down-regulate activity within ventral medial prefrontal and the posterior cingulate/precuneus regions was suggestive of reduced sensitivity to somatic changes and delayed shifts away from rest in ;default network' activity patterns. Controls showed heightened activation of the thalamus, striatal regions and dorsolateral prefrontal cortex suggesting greater arousal and salience-driven sustained attention reactions and greater modulation of affective responses to discomfort and pain. CONCLUSION&INFERENCES This work points to alterations in the central response to visceral pain and discomfort in IBS, highlighting diminished modulation and heightened internalization of affective reactions. SN - 1365-2982 UR - https://www.unboundmedicine.com/medline/citation/20003075/Heightened_central_affective_response_to_visceral_sensations_of_pain_and_discomfort_in_IBS_ L2 - https://doi.org/10.1111/j.1365-2982.2009.01436.x DB - PRIME DP - Unbound Medicine ER -