Tags

Type your tag names separated by a space and hit enter

Childhood immunization and atopic disease into middle-age--a prospective cohort study.
Pediatr Allergy Immunol. 2010 Mar; 21(2 Pt 1):301-6.PA

Abstract

The association between childhood immunizations and risk of atopic diseases is unclear. No study has examined possible associations between childhood immunizations and such diseases in middle age. The Tasmanian Longitudinal Health Study (TAHS) is a population based cohort study of respiratory disease. The TAHS participants were followed from 7 to 44 yrs of age. Immunizations during childhood were examined for any association with asthma and atopic disease at age 44 yrs. Multivariable regression models were used to estimate relative risks while adjusting for confounders. Cox regression was used to estimate the association between childhood immunizations and asthma developing after the age of 7 yrs. We found no association between any childhood immunization (Diphtheria, Tetanus, Pertussis, Polio, Smallpox) and asthma (ORs ranged from 0.87 to 1.17 p > 0.05), eczema (ORs ranged from 0.99 to 1.07 p > 0.05), food allergy (ORs ranged from 0.97 to 1.11 p > 0.05), or hay fever (ORs ranged from 1.02 to 1.05 p > 0.05) at age 44. Nor did we find any association between childhood immunizations and an increased risk of incident asthma after the age of 7 yrs (Diphtheria HR = 1.06, 95% CI 0.82, 1.36; Tetanus HR = 1.13, 95% CI 0.88, 1.44; Pertussis HR = 1.03, 95% CI 0.81, 1.30; Polio HR = 1.15, 95% CI 0.86, 1.54; Smallpox HR = 1.21, 95% CI 0.99, 1.48; DTP HR = 1.05, 95% CI 0.85, 1.30). Our analysis does not support any association between common childhood immunizations and risk of asthma and atopic disease in middle-age. Our findings should provide reassurance that in terms of life time risk of asthma and atopic disease, childhood immunization is safe.

Authors+Show Affiliations

Centre for MEGA Epidemiology, The University of Melbourne, Melbourne, Vic, Australia. mcmat@unimelb.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20003161

Citation

Matheson, Melanie C., et al. "Childhood Immunization and Atopic Disease Into Middle-age--a Prospective Cohort Study." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 21, no. 2 Pt 1, 2010, pp. 301-6.
Matheson MC, Haydn Walters E, Burgess JA, et al. Childhood immunization and atopic disease into middle-age--a prospective cohort study. Pediatr Allergy Immunol. 2010;21(2 Pt 1):301-6.
Matheson, M. C., Haydn Walters, E., Burgess, J. A., Jenkins, M. A., Giles, G. G., Hopper, J. L., Abramson, M. J., & Dharmage, S. C. (2010). Childhood immunization and atopic disease into middle-age--a prospective cohort study. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 21(2 Pt 1), 301-6. https://doi.org/10.1111/j.1399-3038.2009.00950.x
Matheson MC, et al. Childhood Immunization and Atopic Disease Into Middle-age--a Prospective Cohort Study. Pediatr Allergy Immunol. 2010;21(2 Pt 1):301-6. PubMed PMID: 20003161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Childhood immunization and atopic disease into middle-age--a prospective cohort study. AU - Matheson,Melanie C, AU - Haydn Walters,E, AU - Burgess,John A, AU - Jenkins,Mark A, AU - Giles,Graham G, AU - Hopper,John L, AU - Abramson,Michael J, AU - Dharmage,Shyamali C, Y1 - 2009/12/07/ PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/7/30/medline SP - 301 EP - 6 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 21 IS - 2 Pt 1 N2 - The association between childhood immunizations and risk of atopic diseases is unclear. No study has examined possible associations between childhood immunizations and such diseases in middle age. The Tasmanian Longitudinal Health Study (TAHS) is a population based cohort study of respiratory disease. The TAHS participants were followed from 7 to 44 yrs of age. Immunizations during childhood were examined for any association with asthma and atopic disease at age 44 yrs. Multivariable regression models were used to estimate relative risks while adjusting for confounders. Cox regression was used to estimate the association between childhood immunizations and asthma developing after the age of 7 yrs. We found no association between any childhood immunization (Diphtheria, Tetanus, Pertussis, Polio, Smallpox) and asthma (ORs ranged from 0.87 to 1.17 p > 0.05), eczema (ORs ranged from 0.99 to 1.07 p > 0.05), food allergy (ORs ranged from 0.97 to 1.11 p > 0.05), or hay fever (ORs ranged from 1.02 to 1.05 p > 0.05) at age 44. Nor did we find any association between childhood immunizations and an increased risk of incident asthma after the age of 7 yrs (Diphtheria HR = 1.06, 95% CI 0.82, 1.36; Tetanus HR = 1.13, 95% CI 0.88, 1.44; Pertussis HR = 1.03, 95% CI 0.81, 1.30; Polio HR = 1.15, 95% CI 0.86, 1.54; Smallpox HR = 1.21, 95% CI 0.99, 1.48; DTP HR = 1.05, 95% CI 0.85, 1.30). Our analysis does not support any association between common childhood immunizations and risk of asthma and atopic disease in middle-age. Our findings should provide reassurance that in terms of life time risk of asthma and atopic disease, childhood immunization is safe. SN - 1399-3038 UR - https://www.unboundmedicine.com/medline/citation/20003161/Childhood_immunization_and_atopic_disease_into_middle_age__a_prospective_cohort_study_ L2 - https://doi.org/10.1111/j.1399-3038.2009.00950.x DB - PRIME DP - Unbound Medicine ER -