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A new two-phase dimeticone pediculicide shows high efficacy in a comparative bioassay.
BACKGROUNDDimeticones kill head lice by physical means. Here we assessed in a comparative bioassay the ex vivo efficacy of "NYDA sensitiv", a new two-phase dimeticone-based pediculicide similar to a product established on the market, but without fragrances.
METHODSWe compared efficacy of the new product to a positive dimeticone control group, a sample of four other insecticidal and natural head lice products marketed in Germany, and an untreated control. In a bioassay, lice were exposed ex vivo to products and examined for activity for up to 24 hours, following a standard protocol.
RESULTSAfter 6 and 24 hours, 13.7 and 88.5% of untreated control lice did not show major vital signs. In contrast, no lice showed major vital signs 5 minutes after treatment with the new product or the control dimeticone group (NYDA). This effect persisted at all observation points (100% efficacy). Efficacy of 0.5% permethrin (Infectopedicul) ranged between 76 and 96% in evaluations between 5 min and 6 hours. All lice treated with a coconut-based compound (mosquito Läuseshampoo) did not show major vital signs after 5 min, but mortality was only 58% after one hour. Pyrethrum extract (Goldgeist forte) showed an efficacy of 22 - 52% between 5 min and 3 hours after treatment; after 6 hours, 76% of lice were judged dead. An oxyphthirine-based compound (Liberalice DUO LP-PRO) killed 22 - 54% of lice in the first 6 hours.
CONCLUSIONSThe two-phase dimeticone compound NYDA sensitiv is highly efficacious. The removal of fragrances as compared to an established dimeticone product did not affect in vitro efficacy.
Department of Community Health, Federal University of Ceará, Costa Mendes, Fortaleza CE, Brazil. firstname.lastname@example.org, , ,
BMC dermatology 9: 2009 pg 12
Pub Type(s)Comparative Study
Research Support, Non-U.S. Gov't