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Effect of cranberry drink on bacterial adhesion in vitro and vaginal microbiota in healthy females.
Can J Urol. 2009 Dec; 16(6):4901-7.CJ

Abstract

INTRODUCTION/OBJECTIVE

Cranberries have been shown to produce urinary metabolites that influence uropathogen adhesion and prevent urinary tract infections. This study was designed to determine if consuming reconstituted, unsweetened cranberry drink from extract retained its bioactive properties by reducing uropathogen adhesion without adversely affecting urinary calcium, magnesium and the vaginal microflora.

MATERIALS AND METHODS

A randomized crossover study was undertaken in 12 healthy women consuming reconstituted unsweetened cranberry drink, CranActin or water. The urine was collected at 4 hours and 1 week of consumption and evaluated for antiadhesive properties and urinary pH, calcium and magnesium. Vaginal swabs were collected after 1 week of treatment to assess the vaginal microbiota by DGGE.

RESULTS

The resultant urine produced by subjects who consumed 500 ml reconstituted cranberry extract twice per day, significantly reduced the adherence to epithelial cells of P-fimbriated uropathogenic Escherichia coli and showed a tendency towards significance for two E. coli strains expressing fimbriae and an Enterococcus faecalis isolate. The cranberry drink treatment did not alter urinary pH, but reduced calcium and magnesium concentrations compared to water, although not to statistical significance. The reconstituted cranberry drink had no apparent detrimental effect on the vaginal microbiota. However, consuming twice daily resulted in an apparent loss of a potential pathogen from the vagina in 42% subjects.

CONCLUSIONS

The present findings suggest that reconstituted cranberry drink may retain the ability to reduce the risk of UTI by inhibiting pathogen adhesion while not detrimentally affecting urinary pH or vaginal microbiota, or the risk of calculi.

Authors+Show Affiliations

Orebro Life Science Center, School of Science and Technology, Orebro University, Orebro, Sweden.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20003665

Citation

Jass, Jana, and Gregor Reid. "Effect of Cranberry Drink On Bacterial Adhesion in Vitro and Vaginal Microbiota in Healthy Females." The Canadian Journal of Urology, vol. 16, no. 6, 2009, pp. 4901-7.
Jass J, Reid G. Effect of cranberry drink on bacterial adhesion in vitro and vaginal microbiota in healthy females. Can J Urol. 2009;16(6):4901-7.
Jass, J., & Reid, G. (2009). Effect of cranberry drink on bacterial adhesion in vitro and vaginal microbiota in healthy females. The Canadian Journal of Urology, 16(6), 4901-7.
Jass J, Reid G. Effect of Cranberry Drink On Bacterial Adhesion in Vitro and Vaginal Microbiota in Healthy Females. Can J Urol. 2009;16(6):4901-7. PubMed PMID: 20003665.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of cranberry drink on bacterial adhesion in vitro and vaginal microbiota in healthy females. AU - Jass,Jana, AU - Reid,Gregor, PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/9/4/medline SP - 4901 EP - 7 JF - The Canadian journal of urology JO - Can J Urol VL - 16 IS - 6 N2 - INTRODUCTION/OBJECTIVE: Cranberries have been shown to produce urinary metabolites that influence uropathogen adhesion and prevent urinary tract infections. This study was designed to determine if consuming reconstituted, unsweetened cranberry drink from extract retained its bioactive properties by reducing uropathogen adhesion without adversely affecting urinary calcium, magnesium and the vaginal microflora. MATERIALS AND METHODS: A randomized crossover study was undertaken in 12 healthy women consuming reconstituted unsweetened cranberry drink, CranActin or water. The urine was collected at 4 hours and 1 week of consumption and evaluated for antiadhesive properties and urinary pH, calcium and magnesium. Vaginal swabs were collected after 1 week of treatment to assess the vaginal microbiota by DGGE. RESULTS: The resultant urine produced by subjects who consumed 500 ml reconstituted cranberry extract twice per day, significantly reduced the adherence to epithelial cells of P-fimbriated uropathogenic Escherichia coli and showed a tendency towards significance for two E. coli strains expressing fimbriae and an Enterococcus faecalis isolate. The cranberry drink treatment did not alter urinary pH, but reduced calcium and magnesium concentrations compared to water, although not to statistical significance. The reconstituted cranberry drink had no apparent detrimental effect on the vaginal microbiota. However, consuming twice daily resulted in an apparent loss of a potential pathogen from the vagina in 42% subjects. CONCLUSIONS: The present findings suggest that reconstituted cranberry drink may retain the ability to reduce the risk of UTI by inhibiting pathogen adhesion while not detrimentally affecting urinary pH or vaginal microbiota, or the risk of calculi. SN - 1195-9479 UR - https://www.unboundmedicine.com/medline/citation/20003665/Effect_of_cranberry_drink_on_bacterial_adhesion_in_vitro_and_vaginal_microbiota_in_healthy_females_ L2 - http://www.canjurol.com/abstract.php?ArticleID=&version=1.0&PMID=20003665 DB - PRIME DP - Unbound Medicine ER -