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Cognitive impairment following high fat diet consumption is associated with brain inflammation.
J Neuroimmunol 2010; 219(1-2):25-32JN

Abstract

C57Bl/6 mice were administered a high fat, Western diet (WD, 41% fat) or a very high fat lard diet (HFL, 60% fat), and evaluated for cognitive ability using the Stone T-maze and for biochemical markers of brain inflammation. WD consumption resulted in significantly increased body weight and astrocyte reactivity, but not impaired cognition, microglial reactivity, or heightened cytokine levels. HFL increased body weight, and impaired cognition, increased brain inflammation, and decreased BDNF. Collectively, these data suggest that while different diet formulations can increase body weight, the ability of high fat diets to disrupt cognition is linked to brain inflammation.

Authors+Show Affiliations

Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, United States.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20004026

Citation

Pistell, Paul J., et al. "Cognitive Impairment Following High Fat Diet Consumption Is Associated With Brain Inflammation." Journal of Neuroimmunology, vol. 219, no. 1-2, 2010, pp. 25-32.
Pistell PJ, Morrison CD, Gupta S, et al. Cognitive impairment following high fat diet consumption is associated with brain inflammation. J Neuroimmunol. 2010;219(1-2):25-32.
Pistell, P. J., Morrison, C. D., Gupta, S., Knight, A. G., Keller, J. N., Ingram, D. K., & Bruce-Keller, A. J. (2010). Cognitive impairment following high fat diet consumption is associated with brain inflammation. Journal of Neuroimmunology, 219(1-2), pp. 25-32. doi:10.1016/j.jneuroim.2009.11.010.
Pistell PJ, et al. Cognitive Impairment Following High Fat Diet Consumption Is Associated With Brain Inflammation. J Neuroimmunol. 2010 Feb 26;219(1-2):25-32. PubMed PMID: 20004026.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive impairment following high fat diet consumption is associated with brain inflammation. AU - Pistell,Paul J, AU - Morrison,Christopher D, AU - Gupta,Sunita, AU - Knight,Alecia G, AU - Keller,Jeffrey N, AU - Ingram,Donald K, AU - Bruce-Keller,Annadora J, Y1 - 2009/12/08/ PY - 2009/09/23/received PY - 2009/11/11/revised PY - 2009/11/11/accepted PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/3/13/medline SP - 25 EP - 32 JF - Journal of neuroimmunology JO - J. Neuroimmunol. VL - 219 IS - 1-2 N2 - C57Bl/6 mice were administered a high fat, Western diet (WD, 41% fat) or a very high fat lard diet (HFL, 60% fat), and evaluated for cognitive ability using the Stone T-maze and for biochemical markers of brain inflammation. WD consumption resulted in significantly increased body weight and astrocyte reactivity, but not impaired cognition, microglial reactivity, or heightened cytokine levels. HFL increased body weight, and impaired cognition, increased brain inflammation, and decreased BDNF. Collectively, these data suggest that while different diet formulations can increase body weight, the ability of high fat diets to disrupt cognition is linked to brain inflammation. SN - 1872-8421 UR - https://www.unboundmedicine.com/medline/citation/20004026/Cognitive_impairment_following_high_fat_diet_consumption_is_associated_with_brain_inflammation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5728(09)00474-3 DB - PRIME DP - Unbound Medicine ER -