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Impact of metabolic syndrome, diabetes and prediabetes on cardiovascular events: Tehran lipid and glucose study.
Diabetes Res Clin Pract 2010; 87(3):342-7DR

Abstract

AIMS

To compare the cardiovascular disease (CVD) risk associated with the metabolic syndrome (MetS) and dysglycemia, independent of each other during a median follow-up of 6.7 years.

METHODS

Study population included 4018 Iranian subjects >or=40 years, free of CVD or coronary heart disease (CHD) at baseline. Incidence rates and hazard ratio (HR) were estimated by the presence or absence of MetS and dysglycemia. Considering the glycemic status, the ability of MetS in prediction of CVD after adjustment for age, sex and CVD risk factors was assessed.

RESULTS

The prevalence of MetS, impaired fasting glucose or impaired glucose tolerance (IFG/IGT) and diabetes were 51.4%, 27.3%, and 18.7%, respectively. The addition of MetS to diabetes did not change the CVD risk compared to diabetic subjects without MetS (reference group) after adjustment for age and sex [HR: 1.62 (95% CI 0.93-2.81)] and CVD risk factors [HR: 1.49 (95% CI 0.86-2.60)]. However, addition of MetS to IFG/IGT increased the risk of CVD by 2.5 times compared to those with IFG/IGT without MetS (the risk factor adjusted HR: 2.45 (95% CI 1.32-4.55)).

CONCLUSIONS

In Iranian population, MetS did not add to diabetes to predict incident CVD however, IFG/IGT was a significant predictor only in the presence of MetS.

Authors+Show Affiliations

Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. fzhadaegh@endocrine.ac.ir <fzhadaegh@endocrine.ac.ir>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20004035

Citation

Hadaegh, Farzad, et al. "Impact of Metabolic Syndrome, Diabetes and Prediabetes On Cardiovascular Events: Tehran Lipid and Glucose Study." Diabetes Research and Clinical Practice, vol. 87, no. 3, 2010, pp. 342-7.
Hadaegh F, Shafiee G, Ghasemi A, et al. Impact of metabolic syndrome, diabetes and prediabetes on cardiovascular events: Tehran lipid and glucose study. Diabetes Res Clin Pract. 2010;87(3):342-7.
Hadaegh, F., Shafiee, G., Ghasemi, A., Sarbakhsh, P., & Azizi, F. (2010). Impact of metabolic syndrome, diabetes and prediabetes on cardiovascular events: Tehran lipid and glucose study. Diabetes Research and Clinical Practice, 87(3), pp. 342-7. doi:10.1016/j.diabres.2009.11.010.
Hadaegh F, et al. Impact of Metabolic Syndrome, Diabetes and Prediabetes On Cardiovascular Events: Tehran Lipid and Glucose Study. Diabetes Res Clin Pract. 2010;87(3):342-7. PubMed PMID: 20004035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of metabolic syndrome, diabetes and prediabetes on cardiovascular events: Tehran lipid and glucose study. AU - Hadaegh,Farzad, AU - Shafiee,Gita, AU - Ghasemi,Asghar, AU - Sarbakhsh,Parvin, AU - Azizi,Fereidoun, Y1 - 2009/12/08/ PY - 2008/12/30/received PY - 2009/08/24/revised PY - 2009/11/16/accepted PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/6/3/medline SP - 342 EP - 7 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 87 IS - 3 N2 - AIMS: To compare the cardiovascular disease (CVD) risk associated with the metabolic syndrome (MetS) and dysglycemia, independent of each other during a median follow-up of 6.7 years. METHODS: Study population included 4018 Iranian subjects >or=40 years, free of CVD or coronary heart disease (CHD) at baseline. Incidence rates and hazard ratio (HR) were estimated by the presence or absence of MetS and dysglycemia. Considering the glycemic status, the ability of MetS in prediction of CVD after adjustment for age, sex and CVD risk factors was assessed. RESULTS: The prevalence of MetS, impaired fasting glucose or impaired glucose tolerance (IFG/IGT) and diabetes were 51.4%, 27.3%, and 18.7%, respectively. The addition of MetS to diabetes did not change the CVD risk compared to diabetic subjects without MetS (reference group) after adjustment for age and sex [HR: 1.62 (95% CI 0.93-2.81)] and CVD risk factors [HR: 1.49 (95% CI 0.86-2.60)]. However, addition of MetS to IFG/IGT increased the risk of CVD by 2.5 times compared to those with IFG/IGT without MetS (the risk factor adjusted HR: 2.45 (95% CI 1.32-4.55)). CONCLUSIONS: In Iranian population, MetS did not add to diabetes to predict incident CVD however, IFG/IGT was a significant predictor only in the presence of MetS. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/20004035/Impact_of_metabolic_syndrome_diabetes_and_prediabetes_on_cardiovascular_events:_Tehran_lipid_and_glucose_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(09)00481-1 DB - PRIME DP - Unbound Medicine ER -