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Factors associated with persistence of arthralgia among Chikungunya virus-infected travellers: report of 42 French cases.
J Clin Virol. 2010 Jan; 47(1):85-8.JC

Abstract

BACKGROUND

In 2005-2006, a major epidemic of CHIKV infection occurred in the Islands of the south-western Indian Ocean, and longstanding manifestations seemed to be more frequent than described before.

OBJECTIVES

To describe the frequency and related factors of late clinical manifestations of CHIKV infection among imported cases living in Aquitaine area, France.

STUDY DESIGN

All patients recruited through the travel clinic and tropical medicine unit of the University Hospital Centre of Bordeaux with possible CHIKV infection were prospectively recorded, and confirmed cases of CHIKV infection were interviewed 2 years after infection. Factors associated with the persistence of symptoms were determined by multivariate logistic regression.

RESULTS

Among the 29 cases followed, 17 still suffered from arthralgia 2 years after infection, and most of them had never recovered from the initial phase of the condition. The risk of persistent arthralgia tended to be higher among subjects with low educational level, subjects infected in the Reunion Island, and when initial phase lasted 30 days or more and was characterised by a severe pain.

CONCLUSIONS

Consistent with previous studies, our findings showed worsened late manifestations among patients returning from Indian Ocean area. Persistence of symptoms tended to be linked with clinical burden during the acute phase, which can be informative for early recognition and management of patients at risk for developing persistent rheumatic symptoms. Cryoglobulins failed to be identified in seronegative patients with invalidating dengue-like syndrome.

Authors+Show Affiliations

Cellule Interrégionale d'Epidémiologie d'Aquitaine, Bordeaux, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20004145

Citation

Larrieu, Sophie, et al. "Factors Associated With Persistence of Arthralgia Among Chikungunya Virus-infected Travellers: Report of 42 French Cases." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 47, no. 1, 2010, pp. 85-8.
Larrieu S, Pouderoux N, Pistone T, et al. Factors associated with persistence of arthralgia among Chikungunya virus-infected travellers: report of 42 French cases. J Clin Virol. 2010;47(1):85-8.
Larrieu, S., Pouderoux, N., Pistone, T., Filleul, L., Receveur, M. C., Sissoko, D., Ezzedine, K., & Malvy, D. (2010). Factors associated with persistence of arthralgia among Chikungunya virus-infected travellers: report of 42 French cases. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 47(1), 85-8. https://doi.org/10.1016/j.jcv.2009.11.014
Larrieu S, et al. Factors Associated With Persistence of Arthralgia Among Chikungunya Virus-infected Travellers: Report of 42 French Cases. J Clin Virol. 2010;47(1):85-8. PubMed PMID: 20004145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors associated with persistence of arthralgia among Chikungunya virus-infected travellers: report of 42 French cases. AU - Larrieu,Sophie, AU - Pouderoux,Nicolas, AU - Pistone,Thierry, AU - Filleul,Laurent, AU - Receveur,Marie-Catherine, AU - Sissoko,Daouda, AU - Ezzedine,Khaled, AU - Malvy,Denis, Y1 - 2009/12/08/ PY - 2009/06/18/received PY - 2009/11/05/revised PY - 2009/11/11/accepted PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/5/5/medline SP - 85 EP - 8 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 47 IS - 1 N2 - BACKGROUND: In 2005-2006, a major epidemic of CHIKV infection occurred in the Islands of the south-western Indian Ocean, and longstanding manifestations seemed to be more frequent than described before. OBJECTIVES: To describe the frequency and related factors of late clinical manifestations of CHIKV infection among imported cases living in Aquitaine area, France. STUDY DESIGN: All patients recruited through the travel clinic and tropical medicine unit of the University Hospital Centre of Bordeaux with possible CHIKV infection were prospectively recorded, and confirmed cases of CHIKV infection were interviewed 2 years after infection. Factors associated with the persistence of symptoms were determined by multivariate logistic regression. RESULTS: Among the 29 cases followed, 17 still suffered from arthralgia 2 years after infection, and most of them had never recovered from the initial phase of the condition. The risk of persistent arthralgia tended to be higher among subjects with low educational level, subjects infected in the Reunion Island, and when initial phase lasted 30 days or more and was characterised by a severe pain. CONCLUSIONS: Consistent with previous studies, our findings showed worsened late manifestations among patients returning from Indian Ocean area. Persistence of symptoms tended to be linked with clinical burden during the acute phase, which can be informative for early recognition and management of patients at risk for developing persistent rheumatic symptoms. Cryoglobulins failed to be identified in seronegative patients with invalidating dengue-like syndrome. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/20004145/Factors_associated_with_persistence_of_arthralgia_among_Chikungunya_virus_infected_travellers:_report_of_42_French_cases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(09)00555-1 DB - PRIME DP - Unbound Medicine ER -