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Pregnancy in women with polycystic ovary syndrome: the effect of different phenotypes and features on obstetric and neonatal outcomes.

Abstract

OBJECTIVE

To test the hypothesis that the risk of adverse obstetric or neonatal outcomes varies according to different phenotypes of polycystic ovary syndrome (PCOS), and to evaluate the clinical impact of the main features of PCOS.

DESIGN

Prospective controlled clinical study.

SETTING

Academic Departments of Obstetrics and Gynecology, and of Endocrinology, Italy.

PATIENT(S)

Ninety-seven pregnant women with PCOS and 73 healthy pregnant subjects were recruited as cases and controls, respectively.

INTERVENTION(S)

Clinical, biochemical, and ultrasonographic evaluations.

MAIN OUTCOME MEASURE(S)

Obstetric and neonatal outcomes.

RESULT(S)

The relative risk (RR) for adverse obstetric or neonatal outcomes was increased (1.7, 95% confidence interval [CI] 1.12-2.96) in patients with PCOS and varied according to the PCOS phenotype (1.93, 95% CI 1.12-2.96; 2.23, 95% CI 1.21-3.15; 0.54, 95% CI 0.09-1.63, and 0.48, 95% CI 0.31-0.78 for full-blown, nonpolycystic ovaries [PCO], nonhyperandrogenic, and ovulatory phenotypes, respectively). The RRs were 1.57 (95% CI 0.85-2.52) and 0.48 (95% CI 0.31-0.78) for oligoanovulatory and ovulatory patients with PCOS, respectively. The risk for adverse obstetric or neonatal outcomes was affected significantly by ovarian dysfunction and biochemical hyperandrogenism, whereas no significant effect was detected for clinical hyperandrogenism and PCO.

CONCLUSION(S)

The increased risk for adverse obstetric and neonatal outcomes that was observed in patients with PCOS varies widely according to the different phenotypes and features of PCOS.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Obstetrics & Gynecology, University Magna Graecia of Catanzaro, Catanzaro, Italy. stefanopalomba@tin.it

    , , , ,

    Source

    Fertility and sterility 94:5 2010 Oct pg 1805-11

    MeSH

    Abortion, Spontaneous
    Adult
    Anovulation
    Case-Control Studies
    Cesarean Section
    Data Interpretation, Statistical
    Female
    Humans
    Hyperandrogenism
    Phenotype
    Polycystic Ovary Syndrome
    Pregnancy
    Pregnancy Rate
    Premature Birth
    Prospective Studies
    Retrospective Studies
    Risk Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    20004377

    Citation

    Palomba, Stefano, et al. "Pregnancy in Women With Polycystic Ovary Syndrome: the Effect of Different Phenotypes and Features On Obstetric and Neonatal Outcomes." Fertility and Sterility, vol. 94, no. 5, 2010, pp. 1805-11.
    Palomba S, Falbo A, Russo T, et al. Pregnancy in women with polycystic ovary syndrome: the effect of different phenotypes and features on obstetric and neonatal outcomes. Fertil Steril. 2010;94(5):1805-11.
    Palomba, S., Falbo, A., Russo, T., Tolino, A., Orio, F., & Zullo, F. (2010). Pregnancy in women with polycystic ovary syndrome: the effect of different phenotypes and features on obstetric and neonatal outcomes. Fertility and Sterility, 94(5), pp. 1805-11. doi:10.1016/j.fertnstert.2009.10.043.
    Palomba S, et al. Pregnancy in Women With Polycystic Ovary Syndrome: the Effect of Different Phenotypes and Features On Obstetric and Neonatal Outcomes. Fertil Steril. 2010;94(5):1805-11. PubMed PMID: 20004377.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Pregnancy in women with polycystic ovary syndrome: the effect of different phenotypes and features on obstetric and neonatal outcomes. AU - Palomba,Stefano, AU - Falbo,Angela, AU - Russo,Tiziana, AU - Tolino,Achille, AU - Orio,Francesco, AU - Zullo,Fulvio, Y1 - 2009/12/11/ PY - 2009/06/21/received PY - 2009/10/21/revised PY - 2009/10/26/accepted PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/11/4/medline SP - 1805 EP - 11 JF - Fertility and sterility JO - Fertil. Steril. VL - 94 IS - 5 N2 - OBJECTIVE: To test the hypothesis that the risk of adverse obstetric or neonatal outcomes varies according to different phenotypes of polycystic ovary syndrome (PCOS), and to evaluate the clinical impact of the main features of PCOS. DESIGN: Prospective controlled clinical study. SETTING: Academic Departments of Obstetrics and Gynecology, and of Endocrinology, Italy. PATIENT(S): Ninety-seven pregnant women with PCOS and 73 healthy pregnant subjects were recruited as cases and controls, respectively. INTERVENTION(S): Clinical, biochemical, and ultrasonographic evaluations. MAIN OUTCOME MEASURE(S): Obstetric and neonatal outcomes. RESULT(S): The relative risk (RR) for adverse obstetric or neonatal outcomes was increased (1.7, 95% confidence interval [CI] 1.12-2.96) in patients with PCOS and varied according to the PCOS phenotype (1.93, 95% CI 1.12-2.96; 2.23, 95% CI 1.21-3.15; 0.54, 95% CI 0.09-1.63, and 0.48, 95% CI 0.31-0.78 for full-blown, nonpolycystic ovaries [PCO], nonhyperandrogenic, and ovulatory phenotypes, respectively). The RRs were 1.57 (95% CI 0.85-2.52) and 0.48 (95% CI 0.31-0.78) for oligoanovulatory and ovulatory patients with PCOS, respectively. The risk for adverse obstetric or neonatal outcomes was affected significantly by ovarian dysfunction and biochemical hyperandrogenism, whereas no significant effect was detected for clinical hyperandrogenism and PCO. CONCLUSION(S): The increased risk for adverse obstetric and neonatal outcomes that was observed in patients with PCOS varies widely according to the different phenotypes and features of PCOS. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/20004377/Pregnancy_in_women_with_polycystic_ovary_syndrome:_the_effect_of_different_phenotypes_and_features_on_obstetric_and_neonatal_outcomes L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(09)03963-6 DB - PRIME DP - Unbound Medicine ER -