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Inhibitory effect of ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on memory impairment and neuronal toxicity induced by beta-amyloid.
Pharmacol Biochem Behav. 2010 Mar; 95(1):31-40.PB

Abstract

The components of the herb Magnolia officinalis have exhibited antioxidant and neuroprotective activities. In this study, we investigated effects of ethanol extract of M.officinalis and its major component 4-O-methylhonokiol on memory dysfunction and neuronal cell damages caused by A beta. Oral pretreatment of ethanol extract of M. officinalis (2.5, 5 and 10mg/kg) and 4-O-methylhonokiol (1mg/kg) into drinking water for 5 weeks suppressed the intraventricular treatment of A beta(1-42) (0.5 microg/mouse, i.c.v.)-induced memory impairments. In addition, 4-O-methylhonokiol prevented the A beta(1-42)-induced apoptotic cell death as well as beta-secretase expression. 4-O-methylhonokiol also inhibited H(2)O(2) and A beta(1-42)-induced neurotoxicity in cultured neurons as well as PC12 cells by prevention of the reactive oxygen species generation. 4-O-methylhonokiol also directly inhibited beta-secretase activity and A beta fibrilization in vitro. Thus, ethanol extract of M. officinalis may be useful for prevention of the development or progression of AD, and 4-O-methylhonokiol may be a major active component.

Authors+Show Affiliations

College of Pharmacy, Core Research Institute, Chungbuk National University, 12, Gaesin-dong, Heungduk-gu, Cheongju, Chungbuk 361-763, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20004682

Citation

Lee, Jae Woong, et al. "Inhibitory Effect of Ethanol Extract of Magnolia Officinalis and 4-O-methylhonokiol On Memory Impairment and Neuronal Toxicity Induced By Beta-amyloid." Pharmacology, Biochemistry, and Behavior, vol. 95, no. 1, 2010, pp. 31-40.
Lee JW, Lee YK, Lee BJ, et al. Inhibitory effect of ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on memory impairment and neuronal toxicity induced by beta-amyloid. Pharmacol Biochem Behav. 2010;95(1):31-40.
Lee, J. W., Lee, Y. K., Lee, B. J., Nam, S. Y., Lee, S. I., Kim, Y. H., Kim, K. H., Oh, K. W., & Hong, J. T. (2010). Inhibitory effect of ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on memory impairment and neuronal toxicity induced by beta-amyloid. Pharmacology, Biochemistry, and Behavior, 95(1), 31-40. https://doi.org/10.1016/j.pbb.2009.12.003
Lee JW, et al. Inhibitory Effect of Ethanol Extract of Magnolia Officinalis and 4-O-methylhonokiol On Memory Impairment and Neuronal Toxicity Induced By Beta-amyloid. Pharmacol Biochem Behav. 2010;95(1):31-40. PubMed PMID: 20004682.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effect of ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on memory impairment and neuronal toxicity induced by beta-amyloid. AU - Lee,Jae Woong, AU - Lee,Yong Kyung, AU - Lee,Beom Jun, AU - Nam,Sang-Yoon, AU - Lee,Sang Il, AU - Kim,Young Heui, AU - Kim,Ki Ho, AU - Oh,Ki-Wan, AU - Hong,Jin Tae, Y1 - 2009/12/11/ PY - 2009/06/19/received PY - 2009/10/17/revised PY - 2009/12/02/accepted PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/6/2/medline SP - 31 EP - 40 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 95 IS - 1 N2 - The components of the herb Magnolia officinalis have exhibited antioxidant and neuroprotective activities. In this study, we investigated effects of ethanol extract of M.officinalis and its major component 4-O-methylhonokiol on memory dysfunction and neuronal cell damages caused by A beta. Oral pretreatment of ethanol extract of M. officinalis (2.5, 5 and 10mg/kg) and 4-O-methylhonokiol (1mg/kg) into drinking water for 5 weeks suppressed the intraventricular treatment of A beta(1-42) (0.5 microg/mouse, i.c.v.)-induced memory impairments. In addition, 4-O-methylhonokiol prevented the A beta(1-42)-induced apoptotic cell death as well as beta-secretase expression. 4-O-methylhonokiol also inhibited H(2)O(2) and A beta(1-42)-induced neurotoxicity in cultured neurons as well as PC12 cells by prevention of the reactive oxygen species generation. 4-O-methylhonokiol also directly inhibited beta-secretase activity and A beta fibrilization in vitro. Thus, ethanol extract of M. officinalis may be useful for prevention of the development or progression of AD, and 4-O-methylhonokiol may be a major active component. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/20004682/Inhibitory_effect_of_ethanol_extract_of_Magnolia_officinalis_and_4_O_methylhonokiol_on_memory_impairment_and_neuronal_toxicity_induced_by_beta_amyloid_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(09)00344-X DB - PRIME DP - Unbound Medicine ER -