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Flat epithelial atypia is a common subtype of B3 breast lesions and is associated with noninvasive cancer but not with invasive cancer in final excision histology.
Hum Pathol. 2010 Apr; 41(4):522-7.HP

Abstract

The biological behavior and the optimal management of benign breast lesions with uncertain malignant potential, the so-called B3 lesions, found in breast needle core biopsies is still under debate. We addressed this study to compare histologic findings in B3 needle core biopsies with final excision specimens to determine associated rates of malignancy. Consecutive needle core biopsies were performed in a 3-year period (January 1, 2006-December 31, 2008). Biopsies were image-guided (31 by ultrasound, 85 stereotactic vacuum-assisted, 6 unknown) for evaluation of breast abnormalities. We reviewed 122 needle core biopsies with B3 lesions of 91 symptomatic patients and 31 screen-detected women and compared the B3 histologic subtypes with the final excision histology. A total of 1845 needle core biopsies were performed and B3 lesions comprised 6.6% of all B categories. The most common histologic subtype in biopsies was flat epithelia atypia in 35.2%, followed by papillary lesions in 21% and atypical ductal hyperplasia in 20%. Reports on excision specimens were available in 66% (81 patients). Final excision histology was benign in 73 (90.2%) and malignant in 8 (9.8%) patients (2 invasive cancer, 6 ductal carcinoma in situ). Of all B3 subtypes, atypical ductal hyperplasia and flat epithelial atypia were associated with malignancy, whereas only atypical ductal hyperplasia was accompanied by invasive cancer. Of all lesions, flat epithelial atypia was most frequently found in excision specimens (18%). In our study, flat epithelial atypia and atypical ductal hyperplasia are common lesions of the B3 category in needle core biopsies of the breast. Both lesions are associated with malignancy, whereas only atypical ductal hyperplasia was related to invasive cancer. We conclude that an excision biopsy after diagnosis of flat epithelial atypia is recommended depending on clinical and radiologic findings.

Authors+Show Affiliations

Institute of Pathology, Universitätsmedizin Charité Berlin, 10117 Berlin, Germany. aurelia.noske@charite.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20004938

Citation

Noske, Aurelia, et al. "Flat Epithelial Atypia Is a Common Subtype of B3 Breast Lesions and Is Associated With Noninvasive Cancer but Not With Invasive Cancer in Final Excision Histology." Human Pathology, vol. 41, no. 4, 2010, pp. 522-7.
Noske A, Pahl S, Fallenberg E, et al. Flat epithelial atypia is a common subtype of B3 breast lesions and is associated with noninvasive cancer but not with invasive cancer in final excision histology. Hum Pathol. 2010;41(4):522-7.
Noske, A., Pahl, S., Fallenberg, E., Richter-Ehrenstein, C., Buckendahl, A. C., Weichert, W., Schneider, A., Dietel, M., & Denkert, C. (2010). Flat epithelial atypia is a common subtype of B3 breast lesions and is associated with noninvasive cancer but not with invasive cancer in final excision histology. Human Pathology, 41(4), 522-7. https://doi.org/10.1016/j.humpath.2009.09.005
Noske A, et al. Flat Epithelial Atypia Is a Common Subtype of B3 Breast Lesions and Is Associated With Noninvasive Cancer but Not With Invasive Cancer in Final Excision Histology. Hum Pathol. 2010;41(4):522-7. PubMed PMID: 20004938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flat epithelial atypia is a common subtype of B3 breast lesions and is associated with noninvasive cancer but not with invasive cancer in final excision histology. AU - Noske,Aurelia, AU - Pahl,Stefan, AU - Fallenberg,Eva, AU - Richter-Ehrenstein,Christiane, AU - Buckendahl,Ann-Christin, AU - Weichert,Wilko, AU - Schneider,Achim, AU - Dietel,Manfred, AU - Denkert,Carsten, Y1 - 2009/12/11/ PY - 2009/07/01/received PY - 2009/09/11/revised PY - 2009/09/11/accepted PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/4/1/medline SP - 522 EP - 7 JF - Human pathology JO - Hum Pathol VL - 41 IS - 4 N2 - The biological behavior and the optimal management of benign breast lesions with uncertain malignant potential, the so-called B3 lesions, found in breast needle core biopsies is still under debate. We addressed this study to compare histologic findings in B3 needle core biopsies with final excision specimens to determine associated rates of malignancy. Consecutive needle core biopsies were performed in a 3-year period (January 1, 2006-December 31, 2008). Biopsies were image-guided (31 by ultrasound, 85 stereotactic vacuum-assisted, 6 unknown) for evaluation of breast abnormalities. We reviewed 122 needle core biopsies with B3 lesions of 91 symptomatic patients and 31 screen-detected women and compared the B3 histologic subtypes with the final excision histology. A total of 1845 needle core biopsies were performed and B3 lesions comprised 6.6% of all B categories. The most common histologic subtype in biopsies was flat epithelia atypia in 35.2%, followed by papillary lesions in 21% and atypical ductal hyperplasia in 20%. Reports on excision specimens were available in 66% (81 patients). Final excision histology was benign in 73 (90.2%) and malignant in 8 (9.8%) patients (2 invasive cancer, 6 ductal carcinoma in situ). Of all B3 subtypes, atypical ductal hyperplasia and flat epithelial atypia were associated with malignancy, whereas only atypical ductal hyperplasia was accompanied by invasive cancer. Of all lesions, flat epithelial atypia was most frequently found in excision specimens (18%). In our study, flat epithelial atypia and atypical ductal hyperplasia are common lesions of the B3 category in needle core biopsies of the breast. Both lesions are associated with malignancy, whereas only atypical ductal hyperplasia was related to invasive cancer. We conclude that an excision biopsy after diagnosis of flat epithelial atypia is recommended depending on clinical and radiologic findings. SN - 1532-8392 UR - https://www.unboundmedicine.com/medline/citation/20004938/Flat_epithelial_atypia_is_a_common_subtype_of_B3_breast_lesions_and_is_associated_with_noninvasive_cancer_but_not_with_invasive_cancer_in_final_excision_histology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0046-8177(09)00334-7 DB - PRIME DP - Unbound Medicine ER -