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Antimicrobial study of newly synthesized 6-substituted indolo[1,2-c]quinazolines.
Eur J Med Chem. 2010 Mar; 45(3):1200-5.EJ

Abstract

A new series of indolo[1,2-c]quinazoline derivatives were prepared in good yield through reaction of 2-(o-aminophenyl)indole with a variety of arylaldehydes. The structures of the newly synthesized compounds were confirmed by IR, (1)H NMR, (13)C NMR and mass spectral studies and elemental analysis. All the title compounds were investigated for their activity against certain strains of Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis and Streptococcus pyogenes), Gram-negative bacteria (Salmonella typhimurium, Escherichia coli and Klebsiella pneumonia) and pathogenic Fungi (Aspergillus niger, Candida albicans and Trichoderma viridae). Ampicillin and ketoconazole were used as reference compounds. The results revealed that some of synthesized compounds displayed marked activity against all the tested microorganisms.

Authors+Show Affiliations

Department of Chemistry, Kakatiya University, Warangal-506 009, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20005020

Citation

Rohini, Rondla, et al. "Antimicrobial Study of Newly Synthesized 6-substituted Indolo[1,2-c]quinazolines." European Journal of Medicinal Chemistry, vol. 45, no. 3, 2010, pp. 1200-5.
Rohini R, Muralidhar Reddy P, Shanker K, et al. Antimicrobial study of newly synthesized 6-substituted indolo[1,2-c]quinazolines. Eur J Med Chem. 2010;45(3):1200-5.
Rohini, R., Muralidhar Reddy, P., Shanker, K., Hu, A., & Ravinder, V. (2010). Antimicrobial study of newly synthesized 6-substituted indolo[1,2-c]quinazolines. European Journal of Medicinal Chemistry, 45(3), 1200-5. https://doi.org/10.1016/j.ejmech.2009.11.038
Rohini R, et al. Antimicrobial Study of Newly Synthesized 6-substituted Indolo[1,2-c]quinazolines. Eur J Med Chem. 2010;45(3):1200-5. PubMed PMID: 20005020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial study of newly synthesized 6-substituted indolo[1,2-c]quinazolines. AU - Rohini,Rondla, AU - Muralidhar Reddy,P, AU - Shanker,Kanne, AU - Hu,Anren, AU - Ravinder,Vadde, Y1 - 2009/11/26/ PY - 2009/05/10/received PY - 2009/11/13/revised PY - 2009/11/20/accepted PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/7/23/medline SP - 1200 EP - 5 JF - European journal of medicinal chemistry JO - Eur J Med Chem VL - 45 IS - 3 N2 - A new series of indolo[1,2-c]quinazoline derivatives were prepared in good yield through reaction of 2-(o-aminophenyl)indole with a variety of arylaldehydes. The structures of the newly synthesized compounds were confirmed by IR, (1)H NMR, (13)C NMR and mass spectral studies and elemental analysis. All the title compounds were investigated for their activity against certain strains of Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis and Streptococcus pyogenes), Gram-negative bacteria (Salmonella typhimurium, Escherichia coli and Klebsiella pneumonia) and pathogenic Fungi (Aspergillus niger, Candida albicans and Trichoderma viridae). Ampicillin and ketoconazole were used as reference compounds. The results revealed that some of synthesized compounds displayed marked activity against all the tested microorganisms. SN - 1768-3254 UR - https://www.unboundmedicine.com/medline/citation/20005020/Antimicrobial_study_of_newly_synthesized_6_substituted_indolo[12_c]quinazolines_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0223-5234(09)00608-4 DB - PRIME DP - Unbound Medicine ER -