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Evaluation of the association of serum levels of hyaluronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever.
J Clin Virol. 2010 Feb; 47(2):115-9.JC

Abstract

BACKGROUND

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic disease. Pathogenesis of the disease has not been well described yet. A well-known pathogenic feature of CCHF virus is its capability to damage endothelium. Increased hyaluronic acid (HA) levels indicate liver sinusoidal endothelial damage. Soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and vascular endothelial growth factor-A (VEGF-A) play a role in the inflammatory process, vascular damage and plasma leakage.

OBJECTIVES

To investigate whether or not there is a relationship between HA, sICAM-1, sVCAM-1 and VEGF-A serum levels and fatality in CCHF.

STUDY DESIGN

Sixty-one patients who were confirmed by RT-PCR and serological tests for CCHF, included in the current study. HA, sICAM-1, sVCAM-1, VEGF-A levels in serum samples were analyzed by ELISA.

RESULTS

There were statistically significant differences between fatal and non-fatal CCHF patients in terms of HA, sICAM-1, sVCAM-1, and VEGF-A levels. In addition, AST and ALT levels were positively correlated with HA, sICAM-1, sVCAM-1, and VEGF-A levels.

CONCLUSION

HA, sICAM-1, sVCAM-1, and VEGF-A levels of the patients that died during hospitalization were statistically significantly higher than the patients that survived, and this finding suggests that the level of these molecules could be used as a prognostic marker in CCHF.

Authors+Show Affiliations

Department of Infectious Diseases and Clinical Microbiology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey. dbarisozturk@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20005156

Citation

Ozturk, Baris, et al. "Evaluation of the Association of Serum Levels of Hyaluronic Acid, sICAM-1, sVCAM-1, and VEGF-A With Mortality and Prognosis in Patients With Crimean-Congo Hemorrhagic Fever." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 47, no. 2, 2010, pp. 115-9.
Ozturk B, Kuscu F, Tutuncu E, et al. Evaluation of the association of serum levels of hyaluronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever. J Clin Virol. 2010;47(2):115-9.
Ozturk, B., Kuscu, F., Tutuncu, E., Sencan, I., Gurbuz, Y., & Tuzun, H. (2010). Evaluation of the association of serum levels of hyaluronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 47(2), 115-9. https://doi.org/10.1016/j.jcv.2009.10.015
Ozturk B, et al. Evaluation of the Association of Serum Levels of Hyaluronic Acid, sICAM-1, sVCAM-1, and VEGF-A With Mortality and Prognosis in Patients With Crimean-Congo Hemorrhagic Fever. J Clin Virol. 2010;47(2):115-9. PubMed PMID: 20005156.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the association of serum levels of hyaluronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever. AU - Ozturk,Baris, AU - Kuscu,Ferit, AU - Tutuncu,Ediz, AU - Sencan,Irfan, AU - Gurbuz,Yunus, AU - Tuzun,Hakan, Y1 - 2009/12/11/ PY - 2009/04/14/received PY - 2009/10/10/revised PY - 2009/10/27/accepted PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/4/8/medline SP - 115 EP - 9 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 47 IS - 2 N2 - BACKGROUND: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic disease. Pathogenesis of the disease has not been well described yet. A well-known pathogenic feature of CCHF virus is its capability to damage endothelium. Increased hyaluronic acid (HA) levels indicate liver sinusoidal endothelial damage. Soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and vascular endothelial growth factor-A (VEGF-A) play a role in the inflammatory process, vascular damage and plasma leakage. OBJECTIVES: To investigate whether or not there is a relationship between HA, sICAM-1, sVCAM-1 and VEGF-A serum levels and fatality in CCHF. STUDY DESIGN: Sixty-one patients who were confirmed by RT-PCR and serological tests for CCHF, included in the current study. HA, sICAM-1, sVCAM-1, VEGF-A levels in serum samples were analyzed by ELISA. RESULTS: There were statistically significant differences between fatal and non-fatal CCHF patients in terms of HA, sICAM-1, sVCAM-1, and VEGF-A levels. In addition, AST and ALT levels were positively correlated with HA, sICAM-1, sVCAM-1, and VEGF-A levels. CONCLUSION: HA, sICAM-1, sVCAM-1, and VEGF-A levels of the patients that died during hospitalization were statistically significantly higher than the patients that survived, and this finding suggests that the level of these molecules could be used as a prognostic marker in CCHF. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/20005156/Evaluation_of_the_association_of_serum_levels_of_hyaluronic_acid_sICAM_1_sVCAM_1_and_VEGF_A_with_mortality_and_prognosis_in_patients_with_Crimean_Congo_hemorrhagic_fever_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(09)00533-2 DB - PRIME DP - Unbound Medicine ER -