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The role of event-related potentials in cognitive decline in Alzheimer's disease.
Clin Neurophysiol. 2010 Feb; 121(2):194-9.CN

Abstract

OBJECTIVES

Early diagnosis and monitoring of disease progression have become vital in clinical practice as disease modifying treatments for Alzheimer's disease (AD) become available. This one-year prospective study aimed to clarify the usefulness of event-related potentials (ERPs) in cognitive decline and elucidate their cognitive significance in AD.

METHODS

Using the Cognitive Abilities Screening Instrument (CASI) and ERPs, probable AD patients, mild cognitive impairment (MCI) patients, and normal controls were recruited.

RESULTS

The AD and MCI patients had significantly decreased cognitive function and manifested a delay of P300 latency. The P300 latencies demonstrated significantly more prolongation than their baseline values in probable AD and MCI patients, although their CASI scores showed no statistically significant decline. Whereas N100, P200, and N200 components did not reach statistical differences between groups either in the baseline or follow-up assessments and did not show significant change on follow-up.

CONCLUSION

The combination of neuropsychological tests and P300 measurements proved useful in improving reliability and increasing sensitivity to early cognitive decline or disease progression in AD patients.

SIGNIFICANCE

The P300 latency may reflect cognitive decline more sensitively than neuropsychological tests in the longitudinal follow-up of AD patients.

Authors+Show Affiliations

Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20005164

Citation

Lai, Chiou-Lian, et al. "The Role of Event-related Potentials in Cognitive Decline in Alzheimer's Disease." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 121, no. 2, 2010, pp. 194-9.
Lai CL, Lin RT, Liou LM, et al. The role of event-related potentials in cognitive decline in Alzheimer's disease. Clin Neurophysiol. 2010;121(2):194-9.
Lai, C. L., Lin, R. T., Liou, L. M., & Liu, C. K. (2010). The role of event-related potentials in cognitive decline in Alzheimer's disease. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 121(2), 194-9. https://doi.org/10.1016/j.clinph.2009.11.001
Lai CL, et al. The Role of Event-related Potentials in Cognitive Decline in Alzheimer's Disease. Clin Neurophysiol. 2010;121(2):194-9. PubMed PMID: 20005164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of event-related potentials in cognitive decline in Alzheimer's disease. AU - Lai,Chiou-Lian, AU - Lin,Ruey-Tay, AU - Liou,Li-Min, AU - Liu,Ching-Kuan, Y1 - 2009/12/11/ PY - 2008/10/30/received PY - 2009/10/17/revised PY - 2009/11/02/accepted PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/3/10/medline SP - 194 EP - 9 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 121 IS - 2 N2 - OBJECTIVES: Early diagnosis and monitoring of disease progression have become vital in clinical practice as disease modifying treatments for Alzheimer's disease (AD) become available. This one-year prospective study aimed to clarify the usefulness of event-related potentials (ERPs) in cognitive decline and elucidate their cognitive significance in AD. METHODS: Using the Cognitive Abilities Screening Instrument (CASI) and ERPs, probable AD patients, mild cognitive impairment (MCI) patients, and normal controls were recruited. RESULTS: The AD and MCI patients had significantly decreased cognitive function and manifested a delay of P300 latency. The P300 latencies demonstrated significantly more prolongation than their baseline values in probable AD and MCI patients, although their CASI scores showed no statistically significant decline. Whereas N100, P200, and N200 components did not reach statistical differences between groups either in the baseline or follow-up assessments and did not show significant change on follow-up. CONCLUSION: The combination of neuropsychological tests and P300 measurements proved useful in improving reliability and increasing sensitivity to early cognitive decline or disease progression in AD patients. SIGNIFICANCE: The P300 latency may reflect cognitive decline more sensitively than neuropsychological tests in the longitudinal follow-up of AD patients. SN - 1872-8952 UR - https://www.unboundmedicine.com/medline/citation/20005164/The_role_of_event_related_potentials_in_cognitive_decline_in_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(09)00620-8 DB - PRIME DP - Unbound Medicine ER -