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Evaluation of the performance of CareStart Malaria Pf/Pv Combo rapid diagnostic test for the diagnosis of malaria in Jimma, southwestern Ethiopia.
Acta Trop. 2010 Mar; 113(3):285-8.AT

Abstract

OBJECTIVE

To evaluate the diagnostic performance of CareStart Malaria Pf/Pv Combo test relative to microscopy, for the diagnosis of falciparum and vivax malaria in Ethiopia.

METHODS

Two hundred and forty febrile patients visiting the Serbo health center in Jimma zone, southwestern Ethiopia, were involved in this study in 2008. Giemsa-stained thin and thick blood smears were prepared and microscopically examined under a 100x oil immersion microscope objective for Plasmodium species identification and determination of parasitemia respectively. CareStart Malaria Pf/Pv Combo test was performed as per the manufacturers' instruction.

FINDINGS

The validity of CareStart Malaria Pf/Pv Combo test for the diagnosis of Plasmodium was very good with a sensitivity of 95.8%, specificity of 100%, positive predictive value of 100% and negative predictive value of 96%. The test performed equally well for the identification of Plasmodium falciparum and P. vivax. The diagnostic performance of this CareStart test is comparable to light microscopy of thin and thick blood smears.

CONCLUSION

Although CareStart Malaria Pf/Pv Combo test and blood microscopy have comparable diagnostic performance for Plasmodium detection, the CareStart test has the added advantage of being simple to interpret, cost-efficient, and hence it is preferable to use this rapid diagnostic test for malaria diagnosis in areas where microscopy is not accessible and during times of malaria epidemics that are observed approximately every 4-5 years in Ethiopia.

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Publisher Full Text

Authors+Show Affiliations

Mekonnen Z
School of Medical Lab. Sciences, Faculty of Medical Sciences, Jimma University, Jimma, Ethiopia.
Ali S
No affiliation info available
Belay G
No affiliation info available
Suleman S
No affiliation info available
Chatterjee S
No affiliation info available

MeSH

AdolescentAdultAnimalsBloodChildChild, PreschoolDiagnostic Tests, RoutineEthiopiaFemaleHumansInfantMalaria, FalciparumMalaria, VivaxMaleMicroscopyMiddle AgedPlasmodium falciparumPlasmodium vivaxPredictive Value of TestsReagent Kits, DiagnosticSensitivity and SpecificityYoung Adult

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20005196

Citation

Mekonnen, Zeleke, et al. "Evaluation of the Performance of CareStart Malaria Pf/Pv Combo Rapid Diagnostic Test for the Diagnosis of Malaria in Jimma, Southwestern Ethiopia." Acta Tropica, vol. 113, no. 3, 2010, pp. 285-8.
Mekonnen Z, Ali S, Belay G, et al. Evaluation of the performance of CareStart Malaria Pf/Pv Combo rapid diagnostic test for the diagnosis of malaria in Jimma, southwestern Ethiopia. Acta Trop. 2010;113(3):285-8.
Mekonnen, Z., Ali, S., Belay, G., Suleman, S., & Chatterjee, S. (2010). Evaluation of the performance of CareStart Malaria Pf/Pv Combo rapid diagnostic test for the diagnosis of malaria in Jimma, southwestern Ethiopia. Acta Tropica, 113(3), 285-8. https://doi.org/10.1016/j.actatropica.2009.12.001
Mekonnen Z, et al. Evaluation of the Performance of CareStart Malaria Pf/Pv Combo Rapid Diagnostic Test for the Diagnosis of Malaria in Jimma, Southwestern Ethiopia. Acta Trop. 2010;113(3):285-8. PubMed PMID: 20005196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the performance of CareStart Malaria Pf/Pv Combo rapid diagnostic test for the diagnosis of malaria in Jimma, southwestern Ethiopia. AU - Mekonnen,Zeleke, AU - Ali,Solomon, AU - Belay,Getachew, AU - Suleman,Sultan, AU - Chatterjee,Shyama, Y1 - 2009/12/11/ PY - 2009/08/17/received PY - 2009/12/03/revised PY - 2009/12/04/accepted PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/4/22/medline SP - 285 EP - 8 JF - Acta tropica JO - Acta Trop VL - 113 IS - 3 N2 - OBJECTIVE: To evaluate the diagnostic performance of CareStart Malaria Pf/Pv Combo test relative to microscopy, for the diagnosis of falciparum and vivax malaria in Ethiopia. METHODS: Two hundred and forty febrile patients visiting the Serbo health center in Jimma zone, southwestern Ethiopia, were involved in this study in 2008. Giemsa-stained thin and thick blood smears were prepared and microscopically examined under a 100x oil immersion microscope objective for Plasmodium species identification and determination of parasitemia respectively. CareStart Malaria Pf/Pv Combo test was performed as per the manufacturers' instruction. FINDINGS: The validity of CareStart Malaria Pf/Pv Combo test for the diagnosis of Plasmodium was very good with a sensitivity of 95.8%, specificity of 100%, positive predictive value of 100% and negative predictive value of 96%. The test performed equally well for the identification of Plasmodium falciparum and P. vivax. The diagnostic performance of this CareStart test is comparable to light microscopy of thin and thick blood smears. CONCLUSION: Although CareStart Malaria Pf/Pv Combo test and blood microscopy have comparable diagnostic performance for Plasmodium detection, the CareStart test has the added advantage of being simple to interpret, cost-efficient, and hence it is preferable to use this rapid diagnostic test for malaria diagnosis in areas where microscopy is not accessible and during times of malaria epidemics that are observed approximately every 4-5 years in Ethiopia. SN - 1873-6254 UR - https://www.unboundmedicine.com/medline/citation/20005196/Evaluation_of_the_performance_of_CareStart_Malaria_Pf/Pv_Combo_rapid_diagnostic_test_for_the_diagnosis_of_malaria_in_Jimma_southwestern_Ethiopia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0001-706X(09)00372-6 DB - PRIME DP - Unbound Medicine ER -