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Nutrition support with glutamine dipeptide in patients undergoing liver transplantation.
Transplant Proc. 2009 Dec; 41(10):4232-7.TP

Abstract

AIM

The effect of total parenteral nutrition (TPN) support supplemented with alanyl-glutamine (Ala-Gln) dipeptide was investigated in a randomized, controlled clinical trial.

METHODS

Sixty-five patients with the diagnosis of end-stage liver disease or hepatic cellular carcinoma admitted for orthotopic liver transplantation were randomly divided into 3 groups: diet group (n = 21), TPN group (n = 22), and Gln group (n = 22). Patients in the TPN and Gln groups received isocaloric and isonitrogenous TPN for 7 days. Venous heparin blood samples were obtained for assay on days 2 and 9 after surgery; we performed routine pathologic tests.

RESULTS

Compared with the results on day 9 in the TPN group, there was a significant increase in the prognostic nutrition index and in prealbumin among the Gln group. Aspartate aminotransferase improved significantly by Gln treatment compared with traditional TPN support (P < .05). The pathologic results also showed Gln supplementation to reduce hepatic cell injury. A significant decrease in postoperative hospital stay was observed in the Gln group.

CONCLUSIONS

Posttransplant TPN support greatly improved protein metabolism and nutritional state of patients. TPN with Ala-Gln helped to improve synthetic function and to reduce the injury to a transplanted liver.

Authors+Show Affiliations

Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Zhongshang Road 321, Nanjing 210008, China. yudongqiu510@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

20005375

Citation

Qiu, Y, et al. "Nutrition Support With Glutamine Dipeptide in Patients Undergoing Liver Transplantation." Transplantation Proceedings, vol. 41, no. 10, 2009, pp. 4232-7.
Qiu Y, Zhu X, Wang W, et al. Nutrition support with glutamine dipeptide in patients undergoing liver transplantation. Transplant Proc. 2009;41(10):4232-7.
Qiu, Y., Zhu, X., Wang, W., Xu, Q., & Ding, Y. (2009). Nutrition support with glutamine dipeptide in patients undergoing liver transplantation. Transplantation Proceedings, 41(10), 4232-7. https://doi.org/10.1016/j.transproceed.2009.08.076
Qiu Y, et al. Nutrition Support With Glutamine Dipeptide in Patients Undergoing Liver Transplantation. Transplant Proc. 2009;41(10):4232-7. PubMed PMID: 20005375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutrition support with glutamine dipeptide in patients undergoing liver transplantation. AU - Qiu,Y, AU - Zhu,X, AU - Wang,W, AU - Xu,Q, AU - Ding,Y, PY - 2008/04/06/received PY - 2009/03/30/revised PY - 2009/08/04/accepted PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/4/24/medline SP - 4232 EP - 7 JF - Transplantation proceedings JO - Transplant Proc VL - 41 IS - 10 N2 - AIM: The effect of total parenteral nutrition (TPN) support supplemented with alanyl-glutamine (Ala-Gln) dipeptide was investigated in a randomized, controlled clinical trial. METHODS: Sixty-five patients with the diagnosis of end-stage liver disease or hepatic cellular carcinoma admitted for orthotopic liver transplantation were randomly divided into 3 groups: diet group (n = 21), TPN group (n = 22), and Gln group (n = 22). Patients in the TPN and Gln groups received isocaloric and isonitrogenous TPN for 7 days. Venous heparin blood samples were obtained for assay on days 2 and 9 after surgery; we performed routine pathologic tests. RESULTS: Compared with the results on day 9 in the TPN group, there was a significant increase in the prognostic nutrition index and in prealbumin among the Gln group. Aspartate aminotransferase improved significantly by Gln treatment compared with traditional TPN support (P < .05). The pathologic results also showed Gln supplementation to reduce hepatic cell injury. A significant decrease in postoperative hospital stay was observed in the Gln group. CONCLUSIONS: Posttransplant TPN support greatly improved protein metabolism and nutritional state of patients. TPN with Ala-Gln helped to improve synthetic function and to reduce the injury to a transplanted liver. SN - 1873-2623 UR - https://www.unboundmedicine.com/medline/citation/20005375/Nutrition_support_with_glutamine_dipeptide_in_patients_undergoing_liver_transplantation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-1345(09)01405-5 DB - PRIME DP - Unbound Medicine ER -