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An assessment of the effect of human herpesvirus-6 replication on active cytomegalovirus infection after allogeneic stem cell transplantation.
Biol Blood Marrow Transplant. 2010 May; 16(5):653-61.BB

Abstract

Human herpesvirus-6 (HHV-6) may enhance cytomegalovirus (CMV) replication in allogeneic stem cell transplant (allo-SCT) recipients either through direct or indirect mechanisms. Definitive evidence supporting this hypothesis are lacking. We investigated the effect of HHV-6 replication on active CMV infection in 68 allo-SCT recipients. Analysis of plasma HHV-6 and CMV DNAemia was performed by real-time PCR. Enumeration of pp65 and IE-1 CMV-specific IFNgamma CD8(+) and CD4(+)T cells was performed by intracellular cytokine staining. HHV-6 DNAemia occurred in 39.8% of patients, and was significantly associated with subsequent CMV DNAemia in univariate (P=.01), but not in multivariate analysis (P=.65). The peak of HHV-6 DNAemia was not predictive of the development of CMV DNAemia. Timing and kinetics of active CMV infection were comparable in patients either with or without a preceding episode of HHV-6 DNAemia. The occurrence of HHV-6 DNAemia had no impact on CMV-specific T cell immunity reconstitution early after transplant. The receipt of a graft from an HLA-mismatched donor was independently associated with HHV-6 (P=.009) and CMV reactivation (P=.04). The data favor the hypothesis that a state of severe immunosuppression leads to HHV-6 and CMV coactivation, but argue against a role of HHV-6 in predisposing to the development of CMV DNAemia or influencing the course of active CMV infection.

Authors+Show Affiliations

Microbiology Service, Hospital Clínico Universitario, Valencia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20005968

Citation

Tormo, Nuria, et al. "An Assessment of the Effect of Human Herpesvirus-6 Replication On Active Cytomegalovirus Infection After Allogeneic Stem Cell Transplantation." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation, vol. 16, no. 5, 2010, pp. 653-61.
Tormo N, Solano C, de la Cámara R, et al. An assessment of the effect of human herpesvirus-6 replication on active cytomegalovirus infection after allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2010;16(5):653-61.
Tormo, N., Solano, C., de la Cámara, R., Garcia-Noblejas, A., Cardeñoso, L., Clari, M. A., Nieto, J., López, J., Hernández-Boluda, J. C., Remigia, M. J., Benet, I., & Navarro, D. (2010). An assessment of the effect of human herpesvirus-6 replication on active cytomegalovirus infection after allogeneic stem cell transplantation. Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation, 16(5), 653-61. https://doi.org/10.1016/j.bbmt.2009.12.003
Tormo N, et al. An Assessment of the Effect of Human Herpesvirus-6 Replication On Active Cytomegalovirus Infection After Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2010;16(5):653-61. PubMed PMID: 20005968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An assessment of the effect of human herpesvirus-6 replication on active cytomegalovirus infection after allogeneic stem cell transplantation. AU - Tormo,Nuria, AU - Solano,Carlos, AU - de la Cámara,Rafael, AU - Garcia-Noblejas,Ana, AU - Cardeñoso,Laura, AU - Clari,María Angeles, AU - Nieto,José, AU - López,Javier, AU - Hernández-Boluda,Juan Carlos, AU - Remigia,María José, AU - Benet,Isabel, AU - Navarro,David, Y1 - 2010/01/29/ PY - 2009/08/07/received PY - 2009/12/02/accepted PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/8/14/medline SP - 653 EP - 61 JF - Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation JO - Biol Blood Marrow Transplant VL - 16 IS - 5 N2 - Human herpesvirus-6 (HHV-6) may enhance cytomegalovirus (CMV) replication in allogeneic stem cell transplant (allo-SCT) recipients either through direct or indirect mechanisms. Definitive evidence supporting this hypothesis are lacking. We investigated the effect of HHV-6 replication on active CMV infection in 68 allo-SCT recipients. Analysis of plasma HHV-6 and CMV DNAemia was performed by real-time PCR. Enumeration of pp65 and IE-1 CMV-specific IFNgamma CD8(+) and CD4(+)T cells was performed by intracellular cytokine staining. HHV-6 DNAemia occurred in 39.8% of patients, and was significantly associated with subsequent CMV DNAemia in univariate (P=.01), but not in multivariate analysis (P=.65). The peak of HHV-6 DNAemia was not predictive of the development of CMV DNAemia. Timing and kinetics of active CMV infection were comparable in patients either with or without a preceding episode of HHV-6 DNAemia. The occurrence of HHV-6 DNAemia had no impact on CMV-specific T cell immunity reconstitution early after transplant. The receipt of a graft from an HLA-mismatched donor was independently associated with HHV-6 (P=.009) and CMV reactivation (P=.04). The data favor the hypothesis that a state of severe immunosuppression leads to HHV-6 and CMV coactivation, but argue against a role of HHV-6 in predisposing to the development of CMV DNAemia or influencing the course of active CMV infection. SN - 1523-6536 UR - https://www.unboundmedicine.com/medline/citation/20005968/An_assessment_of_the_effect_of_human_herpesvirus_6_replication_on_active_cytomegalovirus_infection_after_allogeneic_stem_cell_transplantation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1083-8791(09)00587-4 DB - PRIME DP - Unbound Medicine ER -