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Selenium status and the risk of esophageal and gastric cancer subtypes: the Netherlands cohort study.

Abstract

BACKGROUND & AIMS

Selenium may protect against the development of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), and gastric cardia adenocarcinoma (GCA). Only in very few studies have the associations with ESCC and GCA been investigated, and no epidemiologic studies exist on EAC.

METHODS

We studied the association between selenium and risk of ESCC, EAC, and GCA within the prospective Netherlands Cohort Study, conducted among 120,852 men and women aged 55-69 years at baseline. In September 1986, the cohort members completed a questionnaire on risk factors for cancer and provided toenail clippings for determination of baseline selenium status. After 16.3 years of follow-up, 64 ESCC, 112 EAC, and 114 GCA cases and 2072 subcohort members were available for case-cohort analysis. Incidence rate ratios (RR) were calculated using Cox proportional hazards models.

RESULTS

In multivariable analyses of selenium status, we found an inverse association with ESCC (RR(per standard unit increment), 0.80; 95% confidence interval [CI]: 0.67-0.96) and a borderline significant inverse association with GCA (RR, 0.91; 95% CI: 0.80-1.02). No overall association was observed for EAC (RR, 1.05; 95% CI: 0.95-1.15), but, for women and never smokers, significant inverse associations were found (RR(per standard unit increment), 0.72; 95% CI: 0.61-0.84 and RR(per standard unit increment), 0.74; 95% CI: 0.64-0.86, respectively).

CONCLUSIONS

This prospective study supports an inverse association between toenail selenium and risk of ESCC and GCA and suggests an inverse association with risk of EAC in subgroups (women, never smokers, and low antioxidant consumers). These associations need confirmation.

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  • Authors+Show Affiliations

    ,

    GROW-School for Oncology and Developmental Biology, Department of Epidemiology, Maastricht University Medical Centre+, Maastricht, The Netherlands. Jessie.Steevens@epid.unimaas.nl

    , ,

    Source

    Gastroenterology 138:5 2010 May pg 1704-13

    MeSH

    Adenocarcinoma
    Aged
    Antioxidants
    Carcinoma, Squamous Cell
    Cohort Studies
    Esophageal Neoplasms
    Female
    Humans
    Male
    Middle Aged
    Nails
    Netherlands
    Proportional Hazards Models
    Prospective Studies
    Risk Assessment
    Risk Factors
    Selenium
    Sex Factors
    Smoking
    Stomach Neoplasms
    Surveys and Questionnaires
    Time Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20006613

    Citation

    Steevens, Jessie, et al. "Selenium Status and the Risk of Esophageal and Gastric Cancer Subtypes: the Netherlands Cohort Study." Gastroenterology, vol. 138, no. 5, 2010, pp. 1704-13.
    Steevens J, van den Brandt PA, Goldbohm RA, et al. Selenium status and the risk of esophageal and gastric cancer subtypes: the Netherlands cohort study. Gastroenterology. 2010;138(5):1704-13.
    Steevens, J., van den Brandt, P. A., Goldbohm, R. A., & Schouten, L. J. (2010). Selenium status and the risk of esophageal and gastric cancer subtypes: the Netherlands cohort study. Gastroenterology, 138(5), pp. 1704-13. doi:10.1053/j.gastro.2009.12.004.
    Steevens J, et al. Selenium Status and the Risk of Esophageal and Gastric Cancer Subtypes: the Netherlands Cohort Study. Gastroenterology. 2010;138(5):1704-13. PubMed PMID: 20006613.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Selenium status and the risk of esophageal and gastric cancer subtypes: the Netherlands cohort study. AU - Steevens,Jessie, AU - van den Brandt,Piet A, AU - Goldbohm,R Alexandra, AU - Schouten,Leo J, Y1 - 2009/12/16/ PY - 2009/08/20/received PY - 2009/10/28/revised PY - 2009/12/03/accepted PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/5/8/medline SP - 1704 EP - 13 JF - Gastroenterology JO - Gastroenterology VL - 138 IS - 5 N2 - BACKGROUND & AIMS: Selenium may protect against the development of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), and gastric cardia adenocarcinoma (GCA). Only in very few studies have the associations with ESCC and GCA been investigated, and no epidemiologic studies exist on EAC. METHODS: We studied the association between selenium and risk of ESCC, EAC, and GCA within the prospective Netherlands Cohort Study, conducted among 120,852 men and women aged 55-69 years at baseline. In September 1986, the cohort members completed a questionnaire on risk factors for cancer and provided toenail clippings for determination of baseline selenium status. After 16.3 years of follow-up, 64 ESCC, 112 EAC, and 114 GCA cases and 2072 subcohort members were available for case-cohort analysis. Incidence rate ratios (RR) were calculated using Cox proportional hazards models. RESULTS: In multivariable analyses of selenium status, we found an inverse association with ESCC (RR(per standard unit increment), 0.80; 95% confidence interval [CI]: 0.67-0.96) and a borderline significant inverse association with GCA (RR, 0.91; 95% CI: 0.80-1.02). No overall association was observed for EAC (RR, 1.05; 95% CI: 0.95-1.15), but, for women and never smokers, significant inverse associations were found (RR(per standard unit increment), 0.72; 95% CI: 0.61-0.84 and RR(per standard unit increment), 0.74; 95% CI: 0.64-0.86, respectively). CONCLUSIONS: This prospective study supports an inverse association between toenail selenium and risk of ESCC and GCA and suggests an inverse association with risk of EAC in subgroups (women, never smokers, and low antioxidant consumers). These associations need confirmation. SN - 1528-0012 UR - https://www.unboundmedicine.com/medline/citation/20006613/Selenium_status_and_the_risk_of_esophageal_and_gastric_cancer_subtypes:_the_Netherlands_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(09)02112-X DB - PRIME DP - Unbound Medicine ER -