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Adherence to a Mediterranean diet and risk of gastric adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study.
Am J Clin Nutr 2010; 91(2):381-90AJ

Abstract

BACKGROUND

The Mediterranean dietary pattern is believed to protect against cancer, although evidence from cohort studies that have examined particular cancer sites is limited.

OBJECTIVE

We aimed to explore the association between adherence to a relative Mediterranean diet (rMED) and incident gastric adenocarcinoma (GC) within the European Prospective Investigation into Cancer and Nutrition study.

DESIGN

The study included 485,044 subjects (144,577 men) aged 35-70 y from 10 European countries. At recruitment, dietary and lifestyle information was collected. An 18-unit rMED score, incorporating 9 key components of the Mediterranean diet, was used to estimate rMED adherence. The association between rMED and GC with respect to anatomic location (cardia and noncardia) and histologic types (diffuse and intestinal) was investigated. A calibration study in a subsample was used to control for dietary measurement error.

RESULTS

After a mean follow-up of 8.9 y, 449 validated incident GC cases were identified and used in the analysis. After stratification by center and age and adjustment for recognized cancer risk factors, high compared with low rMED adherence was associated with a significant reduction in GC risk (hazard ratio: 0.67; 95% CI: 0.47, 0.94). A 1-unit increase in the rMED score was associated with a decreased risk of GC of 5% (95% CI: 0.91, 0.99). There was no evidence of heterogeneity between different anatomic locations or histologic types. The calibrated results showed similar trends (overall hazard ratio for GC: 0.93; 95% CI: 0.89, 0.99).

CONCLUSION

Greater adherence to an rMED is associated with a significant reduction in the risk of incident GC.

Authors+Show Affiliations

Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Idibell, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20007304

Citation

Buckland, Genevieve, et al. "Adherence to a Mediterranean Diet and Risk of Gastric Adenocarcinoma Within the European Prospective Investigation Into Cancer and Nutrition (EPIC) Cohort Study." The American Journal of Clinical Nutrition, vol. 91, no. 2, 2010, pp. 381-90.
Buckland G, Agudo A, Luján L, et al. Adherence to a Mediterranean diet and risk of gastric adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study. Am J Clin Nutr. 2010;91(2):381-90.
Buckland, G., Agudo, A., Luján, L., Jakszyn, P., Bueno-de-Mesquita, H. B., Palli, D., ... González, C. A. (2010). Adherence to a Mediterranean diet and risk of gastric adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study. The American Journal of Clinical Nutrition, 91(2), pp. 381-90. doi:10.3945/ajcn.2009.28209.
Buckland G, et al. Adherence to a Mediterranean Diet and Risk of Gastric Adenocarcinoma Within the European Prospective Investigation Into Cancer and Nutrition (EPIC) Cohort Study. Am J Clin Nutr. 2010;91(2):381-90. PubMed PMID: 20007304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adherence to a Mediterranean diet and risk of gastric adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study. AU - Buckland,Genevieve, AU - Agudo,Antonio, AU - Luján,Leila, AU - Jakszyn,Paula, AU - Bueno-de-Mesquita,H Bas, AU - Palli,Domenico, AU - Boeing,Heiner, AU - Carneiro,Fátima, AU - Krogh,Vittorio, AU - Sacerdote,Carlotta, AU - Tumino,Rosario, AU - Panico,Salvatore, AU - Nesi,Gabriella, AU - Manjer,Jonas, AU - Regnér,Sara, AU - Johansson,Ingegerd, AU - Stenling,Roger, AU - Sanchez,María-José, AU - Dorronsoro,Miren, AU - Barricarte,Aurelio, AU - Navarro,Carmen, AU - Quirós,J Ramón, AU - Allen,Naomi E, AU - Key,Timothy J, AU - Bingham,Sheila, AU - Kaaks,Rudolf, AU - Overvad,Kim, AU - Jensen,Majken, AU - Olsen,Anja, AU - Tjønneland,Anne, AU - Peeters,Petra H M, AU - Numans,Mattijs E, AU - Ocké,Marga C, AU - Clavel-Chapelon,Françoise, AU - Morois,Sophie, AU - Boutron-Ruault,Marie-Christine, AU - Trichopoulou,Antonia, AU - Lagiou,Pagona, AU - Trichopoulos,Dimitrios, AU - Lund,Eiliv, AU - Couto,Elisabeth, AU - Boffeta,Paolo, AU - Jenab,Mazda, AU - Riboli,Elio, AU - Romaguera,Dora, AU - Mouw,Traci, AU - González,Carlos A, Y1 - 2009/12/09/ PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/2/23/medline SP - 381 EP - 90 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 91 IS - 2 N2 - BACKGROUND: The Mediterranean dietary pattern is believed to protect against cancer, although evidence from cohort studies that have examined particular cancer sites is limited. OBJECTIVE: We aimed to explore the association between adherence to a relative Mediterranean diet (rMED) and incident gastric adenocarcinoma (GC) within the European Prospective Investigation into Cancer and Nutrition study. DESIGN: The study included 485,044 subjects (144,577 men) aged 35-70 y from 10 European countries. At recruitment, dietary and lifestyle information was collected. An 18-unit rMED score, incorporating 9 key components of the Mediterranean diet, was used to estimate rMED adherence. The association between rMED and GC with respect to anatomic location (cardia and noncardia) and histologic types (diffuse and intestinal) was investigated. A calibration study in a subsample was used to control for dietary measurement error. RESULTS: After a mean follow-up of 8.9 y, 449 validated incident GC cases were identified and used in the analysis. After stratification by center and age and adjustment for recognized cancer risk factors, high compared with low rMED adherence was associated with a significant reduction in GC risk (hazard ratio: 0.67; 95% CI: 0.47, 0.94). A 1-unit increase in the rMED score was associated with a decreased risk of GC of 5% (95% CI: 0.91, 0.99). There was no evidence of heterogeneity between different anatomic locations or histologic types. The calibrated results showed similar trends (overall hazard ratio for GC: 0.93; 95% CI: 0.89, 0.99). CONCLUSION: Greater adherence to an rMED is associated with a significant reduction in the risk of incident GC. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20007304/Adherence_to_a_Mediterranean_diet_and_risk_of_gastric_adenocarcinoma_within_the_European_Prospective_Investigation_into_Cancer_and_Nutrition__EPIC__cohort_study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.28209 DB - PRIME DP - Unbound Medicine ER -