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Which factors influence glycemic control in the intensive care unit?
Curr Opin Clin Nutr Metab Care. 2010 Mar; 13(2):205-10.CO

Abstract

PURPOSE OF REVIEW

Intensive insulin therapy titrated to restore and maintain blood glucose between 80 and 110 mg/dl (4.4-6.1 mmol/l) was found to improve survival of critically ill patients in one pioneering proof-of-concept study performed in a surgical intensive care unit. The external validity of these findings was investigated.

RECENT FINDINGS

Six independent prospective randomized controlled trials, involving 9877 patients in total, were unable to confirm the survival benefit reported in the pioneering trial. Several hypotheses were proposed to explain this discrepancy, including the case-mix, the features of the usual care, the quality of glucose control and the risks associated with hypoglycemia.

SUMMARY

Before a better understanding and delineation of the conditions associated with and improved outcome by tight glycemic control, the choice of an intermediate glycemic target appears as a safe and effective solution.

Authors+Show Affiliations

Department of General Intensive Care, University Hospital Centre of Liege, Liege, Belgium. Jean-Charles.Preiser@chu.ulg.ac.beNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20010097

Citation

Preiser, Jean-Charles, et al. "Which Factors Influence Glycemic Control in the Intensive Care Unit?" Current Opinion in Clinical Nutrition and Metabolic Care, vol. 13, no. 2, 2010, pp. 205-10.
Preiser JC, Devos P, Chiolero R. Which factors influence glycemic control in the intensive care unit? Curr Opin Clin Nutr Metab Care. 2010;13(2):205-10.
Preiser, J. C., Devos, P., & Chiolero, R. (2010). Which factors influence glycemic control in the intensive care unit? Current Opinion in Clinical Nutrition and Metabolic Care, 13(2), 205-10. https://doi.org/10.1097/MCO.0b013e328335720b
Preiser JC, Devos P, Chiolero R. Which Factors Influence Glycemic Control in the Intensive Care Unit. Curr Opin Clin Nutr Metab Care. 2010;13(2):205-10. PubMed PMID: 20010097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Which factors influence glycemic control in the intensive care unit? AU - Preiser,Jean-Charles, AU - Devos,Philippe, AU - Chiolero,René, PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/6/18/medline SP - 205 EP - 10 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 13 IS - 2 N2 - PURPOSE OF REVIEW: Intensive insulin therapy titrated to restore and maintain blood glucose between 80 and 110 mg/dl (4.4-6.1 mmol/l) was found to improve survival of critically ill patients in one pioneering proof-of-concept study performed in a surgical intensive care unit. The external validity of these findings was investigated. RECENT FINDINGS: Six independent prospective randomized controlled trials, involving 9877 patients in total, were unable to confirm the survival benefit reported in the pioneering trial. Several hypotheses were proposed to explain this discrepancy, including the case-mix, the features of the usual care, the quality of glucose control and the risks associated with hypoglycemia. SUMMARY: Before a better understanding and delineation of the conditions associated with and improved outcome by tight glycemic control, the choice of an intermediate glycemic target appears as a safe and effective solution. SN - 1473-6519 UR - https://www.unboundmedicine.com/medline/citation/20010097/Which_factors_influence_glycemic_control_in_the_intensive_care_unit L2 - https://doi.org/10.1097/MCO.0b013e328335720b DB - PRIME DP - Unbound Medicine ER -