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Study of acute hepatotoxicity of Equisetum arvense L. in rats.
Acta Cir Bras 2009 Nov-Dec; 24(6):449-53AC

Abstract

PURPOSE

To evaluate the acute hepatotoxicity of Equisentum arvense L. in rats.

METHODS

Fifty Wistar rats were used, these being divided in four groups, one being the control (receiving only water) and the other groups receiving graded doses of Equisentum arvense L. (30, 50, and 100mg/kg respectively) for 14 days. Blood samples were obtained to determine TGO, TGP, FA, DHL and GT-gamma activities. After that, hepatic tissue samples were collected for the anatomopathologic analysis.

RESULTS

The anatomopathologic exam of the hepatic tissue showed organ with preserved lobular structure. In the same way, there was no significant change in the seric activities of the hepatic enzymes when compared to control group.

CONCLUSION

The oral treatment with graded doses of Equisentum arvense L. was not able to produce hepatic changes. Further studies are necessary to evaluate the chronic hepatotoxicity of Equisentum arvense L. in rats.

Authors+Show Affiliations

Itajubá School of Medicine, Rua Marechal Juarez Távora 180, Itajubá, Minas Gerais, Brazil. nilocvbaracho@yahoo.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20011829

Citation

Baracho, Nilo César do Vale, et al. "Study of Acute Hepatotoxicity of Equisetum Arvense L. in Rats." Acta Cirurgica Brasileira, vol. 24, no. 6, 2009, pp. 449-53.
Baracho NC, Vicente BB, Arruda GD, et al. Study of acute hepatotoxicity of Equisetum arvense L. in rats. Acta Cir Bras. 2009;24(6):449-53.
Baracho, N. C., Vicente, B. B., Arruda, G. D., Sanches, B. C., & Brito, J. d. (2009). Study of acute hepatotoxicity of Equisetum arvense L. in rats. Acta Cirurgica Brasileira, 24(6), pp. 449-53.
Baracho NC, et al. Study of Acute Hepatotoxicity of Equisetum Arvense L. in Rats. Acta Cir Bras. 2009;24(6):449-53. PubMed PMID: 20011829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study of acute hepatotoxicity of Equisetum arvense L. in rats. AU - Baracho,Nilo César do Vale, AU - Vicente,Bruno Battiston Vilela, AU - Arruda,Guilherme D'Andréa Saba, AU - Sanches,Brunno Cezar Framil, AU - Brito,Jarbas de, PY - 2009/04/15/received PY - 2009/07/24/accepted PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/9/21/medline SP - 449 EP - 53 JF - Acta cirurgica brasileira JO - Acta Cir Bras VL - 24 IS - 6 N2 - PURPOSE: To evaluate the acute hepatotoxicity of Equisentum arvense L. in rats. METHODS: Fifty Wistar rats were used, these being divided in four groups, one being the control (receiving only water) and the other groups receiving graded doses of Equisentum arvense L. (30, 50, and 100mg/kg respectively) for 14 days. Blood samples were obtained to determine TGO, TGP, FA, DHL and GT-gamma activities. After that, hepatic tissue samples were collected for the anatomopathologic analysis. RESULTS: The anatomopathologic exam of the hepatic tissue showed organ with preserved lobular structure. In the same way, there was no significant change in the seric activities of the hepatic enzymes when compared to control group. CONCLUSION: The oral treatment with graded doses of Equisentum arvense L. was not able to produce hepatic changes. Further studies are necessary to evaluate the chronic hepatotoxicity of Equisentum arvense L. in rats. SN - 1678-2674 UR - https://www.unboundmedicine.com/medline/citation/20011829/Study_of_acute_hepatotoxicity_of_Equisetum_arvense_L__in_rats_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502009000600005&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -