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Baroreflex sensitivity and power spectral analysis during autonomic testing in different extrapyramidal syndromes.
Mov Disord. 2010 Feb 15; 25(3):315-24.MD

Abstract

Autonomic dysfunction has been frequently demonstrated in patients with extrapyramidal diseases by cardiovascular autonomic testing. In addition to classical testing, we applied the more detailed baroreflex and spectral analysis on three traditional cardiovascular tests in this study to get additional information on autonomic outflow. We recorded continuously blood pressure, electrocardiogram, and respiration in 35 patients with multiple system atrophy, 32 patients with progressive supranuclear palsy, 46 patients with idiopathic Parkinson's disease and in 27 corresponding healthy subjects during cardiovascular autonomic testing (metronomic breathing, Valsalva manoeuvre, head-up tilt). Baroreflex and spectral analyses were performed by using trigonometric regressive spectral analysis between and during the manoeuvres. Consistent with previous interpretations, our data showed an increase of sympathetic activity in head-up tilt and Valsalva test in healthy controls. This sympathetic activity was significantly decreased in patients with typical and atypical Parkinson syndromes. Significant modulation of baroreflex activity could be observed especially during metronomic breathing; again it was significantly lower in all patient groups. Baroreflex and spectral parameters could not only differentiate between patients and healthy controls, but also differentiate between clinically symptomatic (with autonomic dysfunction as eg. orthostatic hypotension) and asymptomatic patients. In conclusion, our approach allows the evaluation of autonomic variability during short and nonstationary periods of time and may constitute a useful advance in the assessment of autonomic function in both physiological and pathological conditions.

Authors+Show Affiliations

Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20014116

Citation

Friedrich, Constanze, et al. "Baroreflex Sensitivity and Power Spectral Analysis During Autonomic Testing in Different Extrapyramidal Syndromes." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 25, no. 3, 2010, pp. 315-24.
Friedrich C, Rüdiger H, Schmidt C, et al. Baroreflex sensitivity and power spectral analysis during autonomic testing in different extrapyramidal syndromes. Mov Disord. 2010;25(3):315-24.
Friedrich, C., Rüdiger, H., Schmidt, C., Herting, B., Prieur, S., Junghanns, S., Schweitzer, K., Globas, C., Schöls, L., Berg, D., Reichmann, H., & Ziemssen, T. (2010). Baroreflex sensitivity and power spectral analysis during autonomic testing in different extrapyramidal syndromes. Movement Disorders : Official Journal of the Movement Disorder Society, 25(3), 315-24. https://doi.org/10.1002/mds.22844
Friedrich C, et al. Baroreflex Sensitivity and Power Spectral Analysis During Autonomic Testing in Different Extrapyramidal Syndromes. Mov Disord. 2010 Feb 15;25(3):315-24. PubMed PMID: 20014116.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Baroreflex sensitivity and power spectral analysis during autonomic testing in different extrapyramidal syndromes. AU - Friedrich,Constanze, AU - Rüdiger,Heinz, AU - Schmidt,Claudia, AU - Herting,Birgit, AU - Prieur,Silke, AU - Junghanns,Susann, AU - Schweitzer,Katherine, AU - Globas,Christoph, AU - Schöls,Ludger, AU - Berg,Daniela, AU - Reichmann,Heinz, AU - Ziemssen,Tjalf, PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/6/3/medline SP - 315 EP - 24 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 25 IS - 3 N2 - Autonomic dysfunction has been frequently demonstrated in patients with extrapyramidal diseases by cardiovascular autonomic testing. In addition to classical testing, we applied the more detailed baroreflex and spectral analysis on three traditional cardiovascular tests in this study to get additional information on autonomic outflow. We recorded continuously blood pressure, electrocardiogram, and respiration in 35 patients with multiple system atrophy, 32 patients with progressive supranuclear palsy, 46 patients with idiopathic Parkinson's disease and in 27 corresponding healthy subjects during cardiovascular autonomic testing (metronomic breathing, Valsalva manoeuvre, head-up tilt). Baroreflex and spectral analyses were performed by using trigonometric regressive spectral analysis between and during the manoeuvres. Consistent with previous interpretations, our data showed an increase of sympathetic activity in head-up tilt and Valsalva test in healthy controls. This sympathetic activity was significantly decreased in patients with typical and atypical Parkinson syndromes. Significant modulation of baroreflex activity could be observed especially during metronomic breathing; again it was significantly lower in all patient groups. Baroreflex and spectral parameters could not only differentiate between patients and healthy controls, but also differentiate between clinically symptomatic (with autonomic dysfunction as eg. orthostatic hypotension) and asymptomatic patients. In conclusion, our approach allows the evaluation of autonomic variability during short and nonstationary periods of time and may constitute a useful advance in the assessment of autonomic function in both physiological and pathological conditions. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/20014116/Baroreflex_sensitivity_and_power_spectral_analysis_during_autonomic_testing_in_different_extrapyramidal_syndromes_ L2 - https://doi.org/10.1002/mds.22844 DB - PRIME DP - Unbound Medicine ER -