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Social function in multiple X and Y chromosome disorders: XXY, XYY, XXYY, XXXY.
Dev Disabil Res Rev. 2009; 15(4):328-32.DD

Abstract

Klinefelter syndrome (47,XXY) was initially described in the context of its endocrinologic and physical features; however, subsequent studies have revealed specific impairments in verbal skills and social functioning. Males with sex chromosomal aneuploidies are known to have variability in their developmental profile with the majority presenting with expressive language deficits. As a consequence of language delays, they have an increased likelihood of language-based learning disabilities and social-emotional problems that may persist through adulthood. Studies on males with 47,XXY have revealed unique behavioral and social profiles with possible vulnerability to autistic traits. The prevalence of males with more than one extra sex chromosome (e.g., 48,XXYY and 48,XXXY) and an additional Y (e.g., 47,XYY) is less common, but it is important to understand their social functioning as it provides insight into treatment implications.

Authors+Show Affiliations

Department of Human Genetics and Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA. Jvisoot@emory.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20014367

Citation

Visootsak, Jeannie, and John M. Graham. "Social Function in Multiple X and Y Chromosome Disorders: XXY, XYY, XXYY, XXXY." Developmental Disabilities Research Reviews, vol. 15, no. 4, 2009, pp. 328-32.
Visootsak J, Graham JM. Social function in multiple X and Y chromosome disorders: XXY, XYY, XXYY, XXXY. Dev Disabil Res Rev. 2009;15(4):328-32.
Visootsak, J., & Graham, J. M. (2009). Social function in multiple X and Y chromosome disorders: XXY, XYY, XXYY, XXXY. Developmental Disabilities Research Reviews, 15(4), 328-32. https://doi.org/10.1002/ddrr.76
Visootsak J, Graham JM. Social Function in Multiple X and Y Chromosome Disorders: XXY, XYY, XXYY, XXXY. Dev Disabil Res Rev. 2009;15(4):328-32. PubMed PMID: 20014367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Social function in multiple X and Y chromosome disorders: XXY, XYY, XXYY, XXXY. AU - Visootsak,Jeannie, AU - Graham,John M,Jr PY - 2009/12/17/entrez PY - 2009/12/17/pubmed PY - 2010/3/20/medline SP - 328 EP - 32 JF - Developmental disabilities research reviews JO - Dev Disabil Res Rev VL - 15 IS - 4 N2 - Klinefelter syndrome (47,XXY) was initially described in the context of its endocrinologic and physical features; however, subsequent studies have revealed specific impairments in verbal skills and social functioning. Males with sex chromosomal aneuploidies are known to have variability in their developmental profile with the majority presenting with expressive language deficits. As a consequence of language delays, they have an increased likelihood of language-based learning disabilities and social-emotional problems that may persist through adulthood. Studies on males with 47,XXY have revealed unique behavioral and social profiles with possible vulnerability to autistic traits. The prevalence of males with more than one extra sex chromosome (e.g., 48,XXYY and 48,XXXY) and an additional Y (e.g., 47,XYY) is less common, but it is important to understand their social functioning as it provides insight into treatment implications. SN - 1940-5529 UR - https://www.unboundmedicine.com/medline/citation/20014367/Social_function_in_multiple_X_and_Y_chromosome_disorders:_XXY_XYY_XXYY_XXXY_ L2 - https://doi.org/10.1002/ddrr.76 DB - PRIME DP - Unbound Medicine ER -