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Global trends in typhoid and paratyphoid Fever.
Clin Infect Dis. 2010 Jan 15; 50(2):241-6.CI

Abstract

Typhoid and paratyphoid fever continue to be important causes of illness and death, particularly among children and adolescents in south-central and Southeast Asia, where enteric fever is associated with poor sanitation and unsafe food and water. High-quality incidence data from Asia are underpinning efforts to expand access to typhoid vaccines. Efforts are underway to develop vaccines that are immunogenic in infants after a single dose and that can be produced locally in countries of endemicity. The growing importance of Salmonella enterica serotype Paratyphi A in Asia is concerning. Antimicrobial resistance has sequentially emerged to traditional first-line drugs, fluoroquinolones, and third-generation cephalosporins, posing patient treatment challenges. Azithromycin has proven to be an effective alternative for treatment of uncomplicated typhoid fever. The availability of full genome sequences for S. enterica serotype Typhi and S. enterica serotype Paratyphi A confirms their place as monomorphic, human-adapted pathogens vulnerable to control measures if international efforts can be redoubled.

Authors+Show Affiliations

Enteric Diseases Epidemiology Branch, National Center for Zoonotic, Vectorborne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. jcrump@cdc.govNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

20014951

Citation

Crump, John A., and Eric D. Mintz. "Global Trends in Typhoid and Paratyphoid Fever." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 50, no. 2, 2010, pp. 241-6.
Crump JA, Mintz ED. Global trends in typhoid and paratyphoid Fever. Clin Infect Dis. 2010;50(2):241-6.
Crump, J. A., & Mintz, E. D. (2010). Global trends in typhoid and paratyphoid Fever. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 50(2), 241-6. https://doi.org/10.1086/649541
Crump JA, Mintz ED. Global Trends in Typhoid and Paratyphoid Fever. Clin Infect Dis. 2010 Jan 15;50(2):241-6. PubMed PMID: 20014951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Global trends in typhoid and paratyphoid Fever. AU - Crump,John A, AU - Mintz,Eric D, PY - 2009/12/18/entrez PY - 2009/12/18/pubmed PY - 2010/3/4/medline SP - 241 EP - 6 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 50 IS - 2 N2 - Typhoid and paratyphoid fever continue to be important causes of illness and death, particularly among children and adolescents in south-central and Southeast Asia, where enteric fever is associated with poor sanitation and unsafe food and water. High-quality incidence data from Asia are underpinning efforts to expand access to typhoid vaccines. Efforts are underway to develop vaccines that are immunogenic in infants after a single dose and that can be produced locally in countries of endemicity. The growing importance of Salmonella enterica serotype Paratyphi A in Asia is concerning. Antimicrobial resistance has sequentially emerged to traditional first-line drugs, fluoroquinolones, and third-generation cephalosporins, posing patient treatment challenges. Azithromycin has proven to be an effective alternative for treatment of uncomplicated typhoid fever. The availability of full genome sequences for S. enterica serotype Typhi and S. enterica serotype Paratyphi A confirms their place as monomorphic, human-adapted pathogens vulnerable to control measures if international efforts can be redoubled. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/20014951/full_citation L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/649541 DB - PRIME DP - Unbound Medicine ER -