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Apathy and depression in Parkinson disease.
J Geriatr Psychiatry Neurol. 2010 Mar; 23(1):35-41.JG

Abstract

The purpose of this study was to investigate the prevalence and clinical correlates of apathy and depression in Parkinson disease (PD), and to clarify whether apathy can be dissociated from depression. One hundred fifty patients with PD completed the Beck Depression Inventory Second Edition (BDI-II), Starkstein's Apathy Scale (AS), and a quality of life (QOL) battery. Hoehn and Yahr (HY) staging, the Unified Parkinson's Disease Rating Scale (UPDRS), and the Mini-Mental State Examination (MMSE) were performed on the same day. Apathy (AS score > or = 16) was diagnosed in 60% of patients and depression (BDI-II score > or = 14) in 56%. Apathy coexisted with depression in 43% of patients, compared with depression without apathy in 13% and apathy without depression in 17%. Apathy scale score was significantly correlated with UPDRS scores, HY stage, and age, whereas BDI-II score was correlated only with UPDRS scores. Both AS and BDI-II scores were negatively correlated with QOL. However, multiple regression analysis revealed that depression was strongly and negatively associated with emotional well-being and communication, whereas apathy was mainly associated with cognition and stigma. These findings suggest that apathy and depression may be separable in PD, although both are common in patients with PD and are associated with QOL.

Authors+Show Affiliations

Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20015839

Citation

Oguru, Miyako, et al. "Apathy and Depression in Parkinson Disease." Journal of Geriatric Psychiatry and Neurology, vol. 23, no. 1, 2010, pp. 35-41.
Oguru M, Tachibana H, Toda K, et al. Apathy and depression in Parkinson disease. J Geriatr Psychiatry Neurol. 2010;23(1):35-41.
Oguru, M., Tachibana, H., Toda, K., Okuda, B., & Oka, N. (2010). Apathy and depression in Parkinson disease. Journal of Geriatric Psychiatry and Neurology, 23(1), 35-41. https://doi.org/10.1177/0891988709351834
Oguru M, et al. Apathy and Depression in Parkinson Disease. J Geriatr Psychiatry Neurol. 2010;23(1):35-41. PubMed PMID: 20015839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apathy and depression in Parkinson disease. AU - Oguru,Miyako, AU - Tachibana,Hisao, AU - Toda,Kazuo, AU - Okuda,Bungo, AU - Oka,Nobuyuki, Y1 - 2009/12/15/ PY - 2009/12/18/entrez PY - 2009/12/18/pubmed PY - 2010/5/12/medline SP - 35 EP - 41 JF - Journal of geriatric psychiatry and neurology JO - J Geriatr Psychiatry Neurol VL - 23 IS - 1 N2 - The purpose of this study was to investigate the prevalence and clinical correlates of apathy and depression in Parkinson disease (PD), and to clarify whether apathy can be dissociated from depression. One hundred fifty patients with PD completed the Beck Depression Inventory Second Edition (BDI-II), Starkstein's Apathy Scale (AS), and a quality of life (QOL) battery. Hoehn and Yahr (HY) staging, the Unified Parkinson's Disease Rating Scale (UPDRS), and the Mini-Mental State Examination (MMSE) were performed on the same day. Apathy (AS score > or = 16) was diagnosed in 60% of patients and depression (BDI-II score > or = 14) in 56%. Apathy coexisted with depression in 43% of patients, compared with depression without apathy in 13% and apathy without depression in 17%. Apathy scale score was significantly correlated with UPDRS scores, HY stage, and age, whereas BDI-II score was correlated only with UPDRS scores. Both AS and BDI-II scores were negatively correlated with QOL. However, multiple regression analysis revealed that depression was strongly and negatively associated with emotional well-being and communication, whereas apathy was mainly associated with cognition and stigma. These findings suggest that apathy and depression may be separable in PD, although both are common in patients with PD and are associated with QOL. SN - 0891-9887 UR - https://www.unboundmedicine.com/medline/citation/20015839/Apathy_and_depression_in_Parkinson_disease_ L2 - https://journals.sagepub.com/doi/10.1177/0891988709351834?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -