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Relationship between body mass index and quantitative 24-hour urine chemistries in patients with nephrolithiasis.

Abstract

OBJECTIVES

To examine the relationship between body mass index and 24-hour urine constituents in a population of stone-forming patients.

METHODS

A total of 880 patients who presented to a metabolic stone clinic for initial evaluation were analyzed. Patients were stratified by gender and divided into quartiles of body mass index. Associations between body mass index (BMI) and urine parameters were explored using bivariate and multivariate linear regression.

RESULTS

On bivariate analysis, increasing body mass index was associated with a significant increase in sodium, calcium, citrate, uric acid, magnesium, calcium oxalate, uric acid, and a decrease in pH in men. In women, it was associated with a significant increase in sodium, uric acid, oxalate, uric acid, and decreasing pH. On multivariate analysis, BMI was associated only with increases in sodium and calcium oxalate and decrease in pH in men. In women, multivariate analysis demonstrated positive association between BMI and urine sodium, creatinine, and phosphate and a negative relationship with urine citrate and sulfate.

CONCLUSIONS

Increasing body mass index was related to several risk factors for urinary stone disease in this study, including increasing urine sodium and decreasing pH in men and increasing urine uric acid, sodium, and decreasing urine citrate in women. Just as general recommendations for patients with nephrolithiasis include high voided volumes, low dietary sodium, and low animal protein intake, perhaps weight reduction should be included as part of the counseling of stone-formers to optimize 24-hour urine parameters.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Urology, Massachusetts General Hospital, Boston, MA 02114, USA. beisner@partners.org

    ,

    Source

    Urology 75:6 2010 Jun pg 1289-93

    MeSH

    Academic Medical Centers
    Adult
    Age Factors
    Aged
    Body Mass Index
    Calcium Oxalate
    Citric Acid
    Cohort Studies
    Female
    Humans
    Incidence
    Linear Models
    Male
    Middle Aged
    Multivariate Analysis
    Nephrolithiasis
    Probability
    Retrospective Studies
    Risk Assessment
    Severity of Illness Index
    Sex Factors
    Sodium
    Uric Acid
    Urinalysis
    Urine

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    20018350

    Citation

    Eisner, Brian H., et al. "Relationship Between Body Mass Index and Quantitative 24-hour Urine Chemistries in Patients With Nephrolithiasis." Urology, vol. 75, no. 6, 2010, pp. 1289-93.
    Eisner BH, Eisenberg ML, Stoller ML. Relationship between body mass index and quantitative 24-hour urine chemistries in patients with nephrolithiasis. Urology. 2010;75(6):1289-93.
    Eisner, B. H., Eisenberg, M. L., & Stoller, M. L. (2010). Relationship between body mass index and quantitative 24-hour urine chemistries in patients with nephrolithiasis. Urology, 75(6), pp. 1289-93. doi:10.1016/j.urology.2009.09.024.
    Eisner BH, Eisenberg ML, Stoller ML. Relationship Between Body Mass Index and Quantitative 24-hour Urine Chemistries in Patients With Nephrolithiasis. Urology. 2010;75(6):1289-93. PubMed PMID: 20018350.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Relationship between body mass index and quantitative 24-hour urine chemistries in patients with nephrolithiasis. AU - Eisner,Brian H, AU - Eisenberg,Michael L, AU - Stoller,Marshall L, PY - 2009/06/09/received PY - 2009/08/18/revised PY - 2009/09/05/accepted PY - 2009/12/19/entrez PY - 2009/12/19/pubmed PY - 2010/6/26/medline SP - 1289 EP - 93 JF - Urology JO - Urology VL - 75 IS - 6 N2 - OBJECTIVES: To examine the relationship between body mass index and 24-hour urine constituents in a population of stone-forming patients. METHODS: A total of 880 patients who presented to a metabolic stone clinic for initial evaluation were analyzed. Patients were stratified by gender and divided into quartiles of body mass index. Associations between body mass index (BMI) and urine parameters were explored using bivariate and multivariate linear regression. RESULTS: On bivariate analysis, increasing body mass index was associated with a significant increase in sodium, calcium, citrate, uric acid, magnesium, calcium oxalate, uric acid, and a decrease in pH in men. In women, it was associated with a significant increase in sodium, uric acid, oxalate, uric acid, and decreasing pH. On multivariate analysis, BMI was associated only with increases in sodium and calcium oxalate and decrease in pH in men. In women, multivariate analysis demonstrated positive association between BMI and urine sodium, creatinine, and phosphate and a negative relationship with urine citrate and sulfate. CONCLUSIONS: Increasing body mass index was related to several risk factors for urinary stone disease in this study, including increasing urine sodium and decreasing pH in men and increasing urine uric acid, sodium, and decreasing urine citrate in women. Just as general recommendations for patients with nephrolithiasis include high voided volumes, low dietary sodium, and low animal protein intake, perhaps weight reduction should be included as part of the counseling of stone-formers to optimize 24-hour urine parameters. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/20018350/Relationship_between_body_mass_index_and_quantitative_24_hour_urine_chemistries_in_patients_with_nephrolithiasis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(09)02562-X DB - PRIME DP - Unbound Medicine ER -