Tags

Type your tag names separated by a space and hit enter

Oxidative stress and medical antioxidant treatment in male infertility.
Reprod Biomed Online 2009; 19(5):638-59RB

Abstract

Oxidative stress (OS) has been recognized as one of the most important cause of male infertility. Despite the antioxidant activity of seminal plasma, epididymis and spermatozoa, OS damages sperm function and DNA integrity. Since antioxidants suppress the action of reactive oxygen species, these compounds have been used in the medical treatment of male infertility or have been added to the culture medium during sperm separation techniques. Nevertheless, the efficacy of such a treatment has been reported to be very limited. This may relate to: (i) patient selection bias; (ii) late diagnosis of male infertility; (iii) lack of double-blind, placebo-controlled clinical trial; and/or (iv) use of end-points that are not good markers of the presence of OS. This review considers the effects of the main antioxidant compounds used in clinical practice. Overall, the data published suggest that no single antioxidant is able to enhance fertilizing capability in infertile men, whereas a combination of them seems to provide a better approach. Taking into account the pros and the cons of antioxidant treatment of male infertility, the potential advantages that it offers cannot be ignored. Therefore, antioxidant therapy should remain in the forefront of preventive medicine, including human reproductive medicine.

Authors+Show Affiliations

Territorial Center of Andrology, AUSL 8, Syracuse, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20021713

Citation

Lanzafame, Francesco M., et al. "Oxidative Stress and Medical Antioxidant Treatment in Male Infertility." Reproductive Biomedicine Online, vol. 19, no. 5, 2009, pp. 638-59.
Lanzafame FM, La Vignera S, Vicari E, et al. Oxidative stress and medical antioxidant treatment in male infertility. Reprod Biomed Online. 2009;19(5):638-59.
Lanzafame, F. M., La Vignera, S., Vicari, E., & Calogero, A. E. (2009). Oxidative stress and medical antioxidant treatment in male infertility. Reproductive Biomedicine Online, 19(5), pp. 638-59.
Lanzafame FM, et al. Oxidative Stress and Medical Antioxidant Treatment in Male Infertility. Reprod Biomed Online. 2009;19(5):638-59. PubMed PMID: 20021713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress and medical antioxidant treatment in male infertility. AU - Lanzafame,Francesco M, AU - La Vignera,Sandro, AU - Vicari,Enzo, AU - Calogero,Aldo E, PY - 2009/12/22/entrez PY - 2009/12/22/pubmed PY - 2010/9/10/medline SP - 638 EP - 59 JF - Reproductive biomedicine online JO - Reprod. Biomed. Online VL - 19 IS - 5 N2 - Oxidative stress (OS) has been recognized as one of the most important cause of male infertility. Despite the antioxidant activity of seminal plasma, epididymis and spermatozoa, OS damages sperm function and DNA integrity. Since antioxidants suppress the action of reactive oxygen species, these compounds have been used in the medical treatment of male infertility or have been added to the culture medium during sperm separation techniques. Nevertheless, the efficacy of such a treatment has been reported to be very limited. This may relate to: (i) patient selection bias; (ii) late diagnosis of male infertility; (iii) lack of double-blind, placebo-controlled clinical trial; and/or (iv) use of end-points that are not good markers of the presence of OS. This review considers the effects of the main antioxidant compounds used in clinical practice. Overall, the data published suggest that no single antioxidant is able to enhance fertilizing capability in infertile men, whereas a combination of them seems to provide a better approach. Taking into account the pros and the cons of antioxidant treatment of male infertility, the potential advantages that it offers cannot be ignored. Therefore, antioxidant therapy should remain in the forefront of preventive medicine, including human reproductive medicine. SN - 1472-6491 UR - https://www.unboundmedicine.com/medline/citation/20021713/Oxidative_stress_and_medical_antioxidant_treatment_in_male_infertility_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1472-6483(09)00078-9 DB - PRIME DP - Unbound Medicine ER -