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Increased plasma metastin levels in adolescent women with polycystic ovary syndrome.
Eur J Obstet Gynecol Reprod Biol. 2010 Mar; 149(1):72-6.EJ

Abstract

OBJECTIVE

This study was designed to: (1) measure metastin levels in women with polycystic ovary syndrome (PCOS) and in adolescent controls; (2) investigate the possible correlations between metastin and PCOS-related reproductive and metabolic disturbances.

STUDY DESIGN

The study was a clinical study. Nineteen adolescent women with PCOS, twenty-three adult women with the syndrome, and twenty adolescent controls were selected. Blood samples were collected between day 1 and day 5 of a spontaneous bleeding episode in the PCOS groups and of a menstrual cycle of the controls at 9 a.m. after an overnight fast. Circulating levels of LH, FSH, prolactin, testosterone (T), free testosterone, DHEAS, sex hormone-binding globulin, insulin, glucose and metastin were measured.

RESULT(S)

Plasma metastin levels are increased in adolescent women with PCOS compared to adolescent controls. Plasma metastin levels were positively correlated with LH levels, 2-h glucose levels and T levels.

CONCLUSION(S)

These results indicate that metastin is increased in adolescent PCOS women. The increased metastin levels were positively correlated with LH and T levels, and may affect the development of PCOS in adolescents.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, No. 107, Yanjiang Road, Guangzhou 510120, Guangdong, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20022159

Citation

Chen, Xiaoli, et al. "Increased Plasma Metastin Levels in Adolescent Women With Polycystic Ovary Syndrome." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 149, no. 1, 2010, pp. 72-6.
Chen X, Mo Y, Li L, et al. Increased plasma metastin levels in adolescent women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2010;149(1):72-6.
Chen, X., Mo, Y., Li, L., Chen, Y., Li, Y., & Yang, D. (2010). Increased plasma metastin levels in adolescent women with polycystic ovary syndrome. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 149(1), 72-6. https://doi.org/10.1016/j.ejogrb.2009.11.018
Chen X, et al. Increased Plasma Metastin Levels in Adolescent Women With Polycystic Ovary Syndrome. Eur J Obstet Gynecol Reprod Biol. 2010;149(1):72-6. PubMed PMID: 20022159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased plasma metastin levels in adolescent women with polycystic ovary syndrome. AU - Chen,Xiaoli, AU - Mo,Yaqin, AU - Li,Lin, AU - Chen,Yaxiao, AU - Li,Yu, AU - Yang,Dongzi, PY - 2009/07/07/received PY - 2009/10/15/revised PY - 2009/11/19/accepted PY - 2009/12/22/entrez PY - 2009/12/22/pubmed PY - 2010/5/4/medline SP - 72 EP - 6 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur J Obstet Gynecol Reprod Biol VL - 149 IS - 1 N2 - OBJECTIVE: This study was designed to: (1) measure metastin levels in women with polycystic ovary syndrome (PCOS) and in adolescent controls; (2) investigate the possible correlations between metastin and PCOS-related reproductive and metabolic disturbances. STUDY DESIGN: The study was a clinical study. Nineteen adolescent women with PCOS, twenty-three adult women with the syndrome, and twenty adolescent controls were selected. Blood samples were collected between day 1 and day 5 of a spontaneous bleeding episode in the PCOS groups and of a menstrual cycle of the controls at 9 a.m. after an overnight fast. Circulating levels of LH, FSH, prolactin, testosterone (T), free testosterone, DHEAS, sex hormone-binding globulin, insulin, glucose and metastin were measured. RESULT(S): Plasma metastin levels are increased in adolescent women with PCOS compared to adolescent controls. Plasma metastin levels were positively correlated with LH levels, 2-h glucose levels and T levels. CONCLUSION(S): These results indicate that metastin is increased in adolescent PCOS women. The increased metastin levels were positively correlated with LH and T levels, and may affect the development of PCOS in adolescents. SN - 1872-7654 UR - https://www.unboundmedicine.com/medline/citation/20022159/Increased_plasma_metastin_levels_in_adolescent_women_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(09)00693-9 DB - PRIME DP - Unbound Medicine ER -