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Integrated active mixing and biosensing using surface acoustic waves (SAW) and surface plasmon resonance (SPR) on a common substrate.
Lab Chip. 2010 Jan 07; 10(1):111-5.LC

Abstract

This article presents a device incorporating surface plasmon resonance (SPR) sensing and surface acoustic wave (SAW) actuation integrated onto a common LiNbO(3) piezoelectric substrate. The device uses Rayleigh-type SAW to provide active microfluidic mixing in the fluid above the SPR sensor. Validation experiments show that SAW-induced microfluidic mixing results in accelerated binding kinetics of an avidin-biotin assay. Results also show that, though SAW action causes a parasitic SPR response due to heat injection into the fluid, a relatively brief relaxation time following the SAW pulses allows the effect to dissipate, without affecting the overall assay response. Since both SPR sensors and SAW transducers can be fabricated simultaneously using low-cost microfabrication methods on a single substrate, the proposed design is well-suited to lab-on-chip applications.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Renaudin A
Biophotonics and Optoelectronics laboratory, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Chabot V
No affiliation info available
Grondin E
No affiliation info available
Aimez V
No affiliation info available
Charette PG
No affiliation info available

MeSH

AcousticsAvidinBiosensing TechniquesBiotinEquipment DesignMicrofluidicsNiobiumOxidesSurface Plasmon ResonanceSurface PropertiesTemperatureTransducers

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20024058

Citation

Renaudin, Alan, et al. "Integrated Active Mixing and Biosensing Using Surface Acoustic Waves (SAW) and Surface Plasmon Resonance (SPR) On a Common Substrate." Lab On a Chip, vol. 10, no. 1, 2010, pp. 111-5.
Renaudin A, Chabot V, Grondin E, et al. Integrated active mixing and biosensing using surface acoustic waves (SAW) and surface plasmon resonance (SPR) on a common substrate. Lab Chip. 2010;10(1):111-5.
Renaudin, A., Chabot, V., Grondin, E., Aimez, V., & Charette, P. G. (2010). Integrated active mixing and biosensing using surface acoustic waves (SAW) and surface plasmon resonance (SPR) on a common substrate. Lab On a Chip, 10(1), 111-5. https://doi.org/10.1039/b911953a
Renaudin A, et al. Integrated Active Mixing and Biosensing Using Surface Acoustic Waves (SAW) and Surface Plasmon Resonance (SPR) On a Common Substrate. Lab Chip. 2010 Jan 7;10(1):111-5. PubMed PMID: 20024058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Integrated active mixing and biosensing using surface acoustic waves (SAW) and surface plasmon resonance (SPR) on a common substrate. AU - Renaudin,Alan, AU - Chabot,Vincent, AU - Grondin,Etienne, AU - Aimez,Vincent, AU - Charette,Paul G, Y1 - 2009/11/03/ PY - 2009/12/22/entrez PY - 2009/12/22/pubmed PY - 2010/5/8/medline SP - 111 EP - 5 JF - Lab on a chip JO - Lab Chip VL - 10 IS - 1 N2 - This article presents a device incorporating surface plasmon resonance (SPR) sensing and surface acoustic wave (SAW) actuation integrated onto a common LiNbO(3) piezoelectric substrate. The device uses Rayleigh-type SAW to provide active microfluidic mixing in the fluid above the SPR sensor. Validation experiments show that SAW-induced microfluidic mixing results in accelerated binding kinetics of an avidin-biotin assay. Results also show that, though SAW action causes a parasitic SPR response due to heat injection into the fluid, a relatively brief relaxation time following the SAW pulses allows the effect to dissipate, without affecting the overall assay response. Since both SPR sensors and SAW transducers can be fabricated simultaneously using low-cost microfabrication methods on a single substrate, the proposed design is well-suited to lab-on-chip applications. SN - 1473-0197 UR - https://www.unboundmedicine.com/medline/citation/20024058/Integrated_active_mixing_and_biosensing_using_surface_acoustic_waves__SAW__and_surface_plasmon_resonance__SPR__on_a_common_substrate_ L2 - https://doi.org/10.1039/b911953a DB - PRIME DP - Unbound Medicine ER -