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Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain.
Pharmacol Biochem Behav. 2010 Mar; 95(1):88-91.PB

Abstract

In the present study we investigated the effects of lipoic acid (LA) on delta-aminolevulinic dehydratase (delta-ALA-D) and Na(+), K(+)-ATPase activities in rat brain after seizures induction by pilocarpine. Wistar rats were treated with 0.9% saline (i.p., control group), lipoic acid (10mg/kg, i.p., LA group), pilocarpine (400mg/kg, i.p., pilocarpine group), or the combination of LA (10mg/kg, i.p.) with pilocarpine (400mg/kg, i.p.), 30 min before administration of LA (LA plus pilocarpine group). After the treatments all groups were observed for 1h. The enzyme activities (delta-ALA-D and Na(+), K(+)-ATPase) were measured using spectrophotometric methods, and the results were compared with that obtained from saline and pilocarpine-treated animals. Neuroprotective effects of LA against seizures were evaluated based on those enzyme activities. The pilocarpine group showed a reduction in delta-ALA-D and Na(+), K(+)-ATPase activities after seizures. In turn, LA plus pilocarpine abolished the appearance of seizures and reversed the decreased in delta-ALA-D and Na(+), K(+)-ATPase activities produced by seizures, when compared to the pilocarpine seizing group. The results from the present study demonstrate that preadministration of LA abolished seizure episodes induced by pilocarpine in rat, probably by increasing delta-ALA-D and Na(+), K(+)-ATPase activities in rat brain during seizures.

Authors+Show Affiliations

Laboratory of Experimental Research in Biological Sciences of Federal University of Piauí, Piauí, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20026167

Citation

Santos, Itala Mônica de Sales, et al. "Lipoic Acid Blocks Seizures Induced By Pilocarpine Via Increases in Delta-aminolevulinic Dehydratase and Na+, K+-ATPase Activity in Rat Brain." Pharmacology, Biochemistry, and Behavior, vol. 95, no. 1, 2010, pp. 88-91.
Santos IM, Tomé Ada R, Feitosa CM, et al. Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain. Pharmacol Biochem Behav. 2010;95(1):88-91.
Santos, I. M., Tomé, A. d. a. . R., Feitosa, C. M., de Souza, G. F., Feng, D., de Freitas, R. M., & Jordán, J. (2010). Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain. Pharmacology, Biochemistry, and Behavior, 95(1), 88-91. https://doi.org/10.1016/j.pbb.2009.12.011
Santos IM, et al. Lipoic Acid Blocks Seizures Induced By Pilocarpine Via Increases in Delta-aminolevulinic Dehydratase and Na+, K+-ATPase Activity in Rat Brain. Pharmacol Biochem Behav. 2010;95(1):88-91. PubMed PMID: 20026167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain. AU - Santos,Itala Mônica de Sales, AU - Tomé,Adriana da Rocha, AU - Feitosa,Chistiane Mendes, AU - de Souza,Geane Felix, AU - Feng,Dejiang, AU - de Freitas,Rivelilson Mendes, AU - Jordán,Joaquín, Y1 - 2009/12/21/ PY - 2009/09/30/received PY - 2009/12/01/revised PY - 2009/12/14/accepted PY - 2009/12/23/entrez PY - 2009/12/23/pubmed PY - 2010/6/2/medline SP - 88 EP - 91 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 95 IS - 1 N2 - In the present study we investigated the effects of lipoic acid (LA) on delta-aminolevulinic dehydratase (delta-ALA-D) and Na(+), K(+)-ATPase activities in rat brain after seizures induction by pilocarpine. Wistar rats were treated with 0.9% saline (i.p., control group), lipoic acid (10mg/kg, i.p., LA group), pilocarpine (400mg/kg, i.p., pilocarpine group), or the combination of LA (10mg/kg, i.p.) with pilocarpine (400mg/kg, i.p.), 30 min before administration of LA (LA plus pilocarpine group). After the treatments all groups were observed for 1h. The enzyme activities (delta-ALA-D and Na(+), K(+)-ATPase) were measured using spectrophotometric methods, and the results were compared with that obtained from saline and pilocarpine-treated animals. Neuroprotective effects of LA against seizures were evaluated based on those enzyme activities. The pilocarpine group showed a reduction in delta-ALA-D and Na(+), K(+)-ATPase activities after seizures. In turn, LA plus pilocarpine abolished the appearance of seizures and reversed the decreased in delta-ALA-D and Na(+), K(+)-ATPase activities produced by seizures, when compared to the pilocarpine seizing group. The results from the present study demonstrate that preadministration of LA abolished seizure episodes induced by pilocarpine in rat, probably by increasing delta-ALA-D and Na(+), K(+)-ATPase activities in rat brain during seizures. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/20026167/Lipoic_acid_blocks_seizures_induced_by_pilocarpine_via_increases_in_delta_aminolevulinic_dehydratase_and_Na+_K+_ATPase_activity_in_rat_brain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(09)00352-9 DB - PRIME DP - Unbound Medicine ER -