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Blood glucose and risk of incident and fatal cancer in the metabolic syndrome and cancer project (me-can): analysis of six prospective cohorts.
PLoS Med. 2009 Dec; 6(12):e1000201.PM

Abstract

BACKGROUND

Prospective studies have indicated that elevated blood glucose levels may be linked with increased cancer risk, but the strength of the association is unclear. We examined the association between blood glucose and cancer risk in a prospective study of six European cohorts.

METHODS AND FINDINGS

The Metabolic syndrome and Cancer project (Me-Can) includes cohorts from Norway, Austria, and Sweden; the current study included 274,126 men and 275,818 women. Mean age at baseline was 44.8 years and mean follow-up time was 10.4 years. Excluding the first year of follow-up, 18,621 men and 11,664 women were diagnosed with cancer, and 6,973 men and 3,088 women died of cancer. We used Cox regression models to calculate relative risk (RR) for glucose levels, and included adjustment for body mass index (BMI) and smoking status in the analyses. RRs were corrected for regression dilution ratio of glucose. RR (95% confidence interval) per 1 mmol/l increment of glucose for overall incident cancer was 1.05 (1.01-1.10) in men and 1.11 (1.05-1.16) in women, and corresponding RRs for fatal cancer were 1.15 (1.07-1.22) and 1.21 (1.11-1.33), respectively. Significant increases in risk among men were found for incident and fatal cancer of the liver, gallbladder, and respiratory tract, for incident thyroid cancer and multiple myeloma, and for fatal rectal cancer. In women, significant associations were found for incident and fatal cancer of the pancreas, for incident urinary bladder cancer, and for fatal cancer of the uterine corpus, cervix uteri, and stomach.

CONCLUSIONS

Data from our study indicate that abnormal glucose metabolism, independent of BMI, is associated with an increased risk of cancer overall and at several cancer sites. Our data showed stronger associations among women than among men, and for fatal cancer compared to incident cancer. Please see later in the article for the Editors' Summary.

Authors+Show Affiliations

Department of Surgical and Perioperative sciences, Urology and Andrology, Umeå University, Umeå, Sweden. tanja.stocks@urologi.umu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20027213

Citation

Stocks, Tanja, et al. "Blood Glucose and Risk of Incident and Fatal Cancer in the Metabolic Syndrome and Cancer Project (me-can): Analysis of Six Prospective Cohorts." PLoS Medicine, vol. 6, no. 12, 2009, pp. e1000201.
Stocks T, Rapp K, Bjørge T, et al. Blood glucose and risk of incident and fatal cancer in the metabolic syndrome and cancer project (me-can): analysis of six prospective cohorts. PLoS Med. 2009;6(12):e1000201.
Stocks, T., Rapp, K., Bjørge, T., Manjer, J., Ulmer, H., Selmer, R., Lukanova, A., Johansen, D., Concin, H., Tretli, S., Hallmans, G., Jonsson, H., & Stattin, P. (2009). Blood glucose and risk of incident and fatal cancer in the metabolic syndrome and cancer project (me-can): analysis of six prospective cohorts. PLoS Medicine, 6(12), e1000201. https://doi.org/10.1371/journal.pmed.1000201
Stocks T, et al. Blood Glucose and Risk of Incident and Fatal Cancer in the Metabolic Syndrome and Cancer Project (me-can): Analysis of Six Prospective Cohorts. PLoS Med. 2009;6(12):e1000201. PubMed PMID: 20027213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood glucose and risk of incident and fatal cancer in the metabolic syndrome and cancer project (me-can): analysis of six prospective cohorts. AU - Stocks,Tanja, AU - Rapp,Kilian, AU - Bjørge,Tone, AU - Manjer,Jonas, AU - Ulmer,Hanno, AU - Selmer,Randi, AU - Lukanova,Annekatrin, AU - Johansen,Dorthe, AU - Concin,Hans, AU - Tretli,Steinar, AU - Hallmans,Göran, AU - Jonsson,Håkan, AU - Stattin,Pär, Y1 - 2009/12/22/ PY - 2009/03/31/received PY - 2009/11/10/accepted PY - 2009/12/23/entrez PY - 2009/12/23/pubmed PY - 2010/2/23/medline SP - e1000201 EP - e1000201 JF - PLoS medicine JO - PLoS Med. VL - 6 IS - 12 N2 - BACKGROUND: Prospective studies have indicated that elevated blood glucose levels may be linked with increased cancer risk, but the strength of the association is unclear. We examined the association between blood glucose and cancer risk in a prospective study of six European cohorts. METHODS AND FINDINGS: The Metabolic syndrome and Cancer project (Me-Can) includes cohorts from Norway, Austria, and Sweden; the current study included 274,126 men and 275,818 women. Mean age at baseline was 44.8 years and mean follow-up time was 10.4 years. Excluding the first year of follow-up, 18,621 men and 11,664 women were diagnosed with cancer, and 6,973 men and 3,088 women died of cancer. We used Cox regression models to calculate relative risk (RR) for glucose levels, and included adjustment for body mass index (BMI) and smoking status in the analyses. RRs were corrected for regression dilution ratio of glucose. RR (95% confidence interval) per 1 mmol/l increment of glucose for overall incident cancer was 1.05 (1.01-1.10) in men and 1.11 (1.05-1.16) in women, and corresponding RRs for fatal cancer were 1.15 (1.07-1.22) and 1.21 (1.11-1.33), respectively. Significant increases in risk among men were found for incident and fatal cancer of the liver, gallbladder, and respiratory tract, for incident thyroid cancer and multiple myeloma, and for fatal rectal cancer. In women, significant associations were found for incident and fatal cancer of the pancreas, for incident urinary bladder cancer, and for fatal cancer of the uterine corpus, cervix uteri, and stomach. CONCLUSIONS: Data from our study indicate that abnormal glucose metabolism, independent of BMI, is associated with an increased risk of cancer overall and at several cancer sites. Our data showed stronger associations among women than among men, and for fatal cancer compared to incident cancer. Please see later in the article for the Editors' Summary. SN - 1549-1676 UR - https://www.unboundmedicine.com/medline/citation/20027213/Blood_glucose_and_risk_of_incident_and_fatal_cancer_in_the_metabolic_syndrome_and_cancer_project__me_can_:_analysis_of_six_prospective_cohorts_ L2 - http://dx.plos.org/10.1371/journal.pmed.1000201 DB - PRIME DP - Unbound Medicine ER -