Tags

Type your tag names separated by a space and hit enter

Comparative safety evaluation of Chinese Pu-erh green tea extract and Pu-erh black tea extract in Wistar rats.
J Agric Food Chem. 2010 Jan 27; 58(2):1350-8.JA

Abstract

Pu-erh teas are believed to be beneficial beverages for health since they possess several pharmacological properties such as antioxidation, hypocholesterolemia, and antiobesity properties, but their potential toxicities when administered at a high dose as concentrated extracts have not been completely investigated. In this study, the chemical components in Pu-erh green tea and Pu-erh black tea were analyzed and compared, and the safety of tea extracts was evaluated in Wistar rats. The polysaccharide, tea pigment, and flavonoid levels were substantially increased in the Pu-erh black tea, while the polyphenol and free amino acid levels were higher in unfermented green tea. Low toxicities of Pu-erh green tea extract (GTE) were observed at doses of 2500 and 5000 mg/kg/day with a 28-day subacute study. Serum biochemical data including alanine aminotransferase increased to 5000 mg/kg/day GTE males, and creatinine (Cr) increased in all 5000 mg/kg/day GTE groups and 2500 mg/kg/day GTE males. Slight bile duct hyperplasia in the liver was also observed. The target organs of GTE were considered to be the liver and kidney. Comparatively, no adverse effects were observed in Pu-erh black tea extract (BTE)-treated rats. In conclusion, a dose of 1250 mg/kg/day for GTE and 5000 mg/kg/day for BTE following oral administration could be considered safe under the conditions of this study.

Authors+Show Affiliations

Department of Nutrition and Food Hygiene, School of Public Health, MOE Key Lab of Environment and Health, School of Public Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, People'sRepublic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20028013

Citation

Wang, Di, et al. "Comparative Safety Evaluation of Chinese Pu-erh Green Tea Extract and Pu-erh Black Tea Extract in Wistar Rats." Journal of Agricultural and Food Chemistry, vol. 58, no. 2, 2010, pp. 1350-8.
Wang D, Xiao R, Hu X, et al. Comparative safety evaluation of Chinese Pu-erh green tea extract and Pu-erh black tea extract in Wistar rats. J Agric Food Chem. 2010;58(2):1350-8.
Wang, D., Xiao, R., Hu, X., Xu, K., Hou, Y., Zhong, Y., Meng, J., Fan, B., & Liu, L. (2010). Comparative safety evaluation of Chinese Pu-erh green tea extract and Pu-erh black tea extract in Wistar rats. Journal of Agricultural and Food Chemistry, 58(2), 1350-8. https://doi.org/10.1021/jf902171h
Wang D, et al. Comparative Safety Evaluation of Chinese Pu-erh Green Tea Extract and Pu-erh Black Tea Extract in Wistar Rats. J Agric Food Chem. 2010 Jan 27;58(2):1350-8. PubMed PMID: 20028013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative safety evaluation of Chinese Pu-erh green tea extract and Pu-erh black tea extract in Wistar rats. AU - Wang,Di, AU - Xiao,Rong, AU - Hu,Xueting, AU - Xu,Kunlong, AU - Hou,Yan, AU - Zhong,Ying, AU - Meng,Jie, AU - Fan,Bolin, AU - Liu,Liegang, PY - 2009/12/24/entrez PY - 2009/12/24/pubmed PY - 2010/3/26/medline SP - 1350 EP - 8 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 58 IS - 2 N2 - Pu-erh teas are believed to be beneficial beverages for health since they possess several pharmacological properties such as antioxidation, hypocholesterolemia, and antiobesity properties, but their potential toxicities when administered at a high dose as concentrated extracts have not been completely investigated. In this study, the chemical components in Pu-erh green tea and Pu-erh black tea were analyzed and compared, and the safety of tea extracts was evaluated in Wistar rats. The polysaccharide, tea pigment, and flavonoid levels were substantially increased in the Pu-erh black tea, while the polyphenol and free amino acid levels were higher in unfermented green tea. Low toxicities of Pu-erh green tea extract (GTE) were observed at doses of 2500 and 5000 mg/kg/day with a 28-day subacute study. Serum biochemical data including alanine aminotransferase increased to 5000 mg/kg/day GTE males, and creatinine (Cr) increased in all 5000 mg/kg/day GTE groups and 2500 mg/kg/day GTE males. Slight bile duct hyperplasia in the liver was also observed. The target organs of GTE were considered to be the liver and kidney. Comparatively, no adverse effects were observed in Pu-erh black tea extract (BTE)-treated rats. In conclusion, a dose of 1250 mg/kg/day for GTE and 5000 mg/kg/day for BTE following oral administration could be considered safe under the conditions of this study. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/20028013/Comparative_safety_evaluation_of_Chinese_Pu_erh_green_tea_extract_and_Pu_erh_black_tea_extract_in_Wistar_rats_ L2 - https://doi.org/10.1021/jf902171h DB - PRIME DP - Unbound Medicine ER -