Tags

Type your tag names separated by a space and hit enter

Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment.
Br J Nutr. 2010 Mar; 103(5):730-4.BJ

Abstract

Concord grape juice contains polyphenol compounds, which have antioxidant and anti-inflammatory properties and influence neuronal signalling. Concord grape juice supplementation has been shown to reduce inflammation, blood pressure and vascular pathology in individuals with CVD, and consumption of such flavonoid-containing foods is associated with a reduced risk for dementia. In addition, preliminary animal data have indicated improvement in memory and motor function with grape juice supplementation, suggesting potential for cognitive benefit in ageing humans. In this initial investigation of neurocognitive effects, we enrolled twelve older adults with memory decline but not dementia in a randomised, placebo-controlled, double-blind trial with Concord grape juice supplementation for 12 weeks. We observed significant improvement in a measure of verbal learning and non-significant enhancement of verbal and spatial recall. There was no appreciable effect of the intervention on depressive symptoms and no effect on weight or waist circumference. A small increase in fasting insulin was observed for those consuming grape juice. These preliminary findings suggest that supplementation with Concord grape juice may enhance cognitive function for older adults with early memory decline and establish a basis for more comprehensive investigations to evaluate potential benefit and assess mechanisms of action.

Authors+Show Affiliations

Department of Psychiatry, University of Cincinnati Academic Health Center, Cincinnati, OH, USA. robert.krikorian@uc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20028599

Citation

Krikorian, Robert, et al. "Concord Grape Juice Supplementation Improves Memory Function in Older Adults With Mild Cognitive Impairment." The British Journal of Nutrition, vol. 103, no. 5, 2010, pp. 730-4.
Krikorian R, Nash TA, Shidler MD, et al. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2010;103(5):730-4.
Krikorian, R., Nash, T. A., Shidler, M. D., Shukitt-Hale, B., & Joseph, J. A. (2010). Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. The British Journal of Nutrition, 103(5), 730-4. https://doi.org/10.1017/S0007114509992364
Krikorian R, et al. Concord Grape Juice Supplementation Improves Memory Function in Older Adults With Mild Cognitive Impairment. Br J Nutr. 2010;103(5):730-4. PubMed PMID: 20028599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. AU - Krikorian,Robert, AU - Nash,Tiffany A, AU - Shidler,Marcelle D, AU - Shukitt-Hale,Barbara, AU - Joseph,James A, Y1 - 2009/12/23/ PY - 2009/12/24/entrez PY - 2009/12/24/pubmed PY - 2010/3/20/medline SP - 730 EP - 4 JF - The British journal of nutrition JO - Br J Nutr VL - 103 IS - 5 N2 - Concord grape juice contains polyphenol compounds, which have antioxidant and anti-inflammatory properties and influence neuronal signalling. Concord grape juice supplementation has been shown to reduce inflammation, blood pressure and vascular pathology in individuals with CVD, and consumption of such flavonoid-containing foods is associated with a reduced risk for dementia. In addition, preliminary animal data have indicated improvement in memory and motor function with grape juice supplementation, suggesting potential for cognitive benefit in ageing humans. In this initial investigation of neurocognitive effects, we enrolled twelve older adults with memory decline but not dementia in a randomised, placebo-controlled, double-blind trial with Concord grape juice supplementation for 12 weeks. We observed significant improvement in a measure of verbal learning and non-significant enhancement of verbal and spatial recall. There was no appreciable effect of the intervention on depressive symptoms and no effect on weight or waist circumference. A small increase in fasting insulin was observed for those consuming grape juice. These preliminary findings suggest that supplementation with Concord grape juice may enhance cognitive function for older adults with early memory decline and establish a basis for more comprehensive investigations to evaluate potential benefit and assess mechanisms of action. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/20028599/Concord_grape_juice_supplementation_improves_memory_function_in_older_adults_with_mild_cognitive_impairment_ L2 - https://www.cambridge.org/core/product/identifier/S0007114509992364/type/journal_article DB - PRIME DP - Unbound Medicine ER -