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Predictors of one-year disability and death in Chinese hospitalized women after ischemic stroke.
Cerebrovasc Dis. 2010 Feb; 29(3):255-62.CD

Abstract

BACKGROUND AND PURPOSE

Women have a worse functional outcome after stroke, but the specific factors associated with a poor outcome in women are rarely reported. This study was designed to investigate the clinical predictors of 1-year disability and death in women after ischemic stroke.

METHODS

Patients with ischemic stroke consecutively registered from March 2002 to July 2007 were followed prospectively for 1 year. Multivariate regression models were employed to analyze predictors of disability (defined as modified Rankin scale score, mRS, 3-5) and death.

RESULTS

A total of 2,774 ischemic stroke patients were included with 1,119 (40.3%) females (mean age 65 +/- 13.5 years). Among female patients, disability (mRS 3-5) is 1.68-fold higher and case fatality is 1.23-fold higher than in men at the 1-year follow-up. Diabetes is an independent predictor of 1-year disability among women (odds ratio, 1.56; 95% confidence interval, CI, 1.01-2.39). In-hospital acute renal failure (hazard ratio, HR, 7.26; 95% CI, 3.47-5.19), suboptimal antiplatelets (HR, 0.55; 95% CI, 0.37-0.83) and antihypertensive therapy (HR, 0.61; 95% CI, 0.42-0.90) are associated with death at 1 year after stroke among women.

CONCLUSIONS

The present study indicates that diabetes, in-hospital acute renal failure, suboptimal antiplatelets and antihypertensive therapy are the possible explanations for the poor 1-year outcome of women hospitalized with ischemic stroke.

Authors+Show Affiliations

Stroke Clinical Research Unit, Department of Neurology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20029199

Citation

Kong, Fan-Yi, et al. "Predictors of One-year Disability and Death in Chinese Hospitalized Women After Ischemic Stroke." Cerebrovascular Diseases (Basel, Switzerland), vol. 29, no. 3, 2010, pp. 255-62.
Kong FY, Tao WD, Hao ZL, et al. Predictors of one-year disability and death in Chinese hospitalized women after ischemic stroke. Cerebrovasc Dis. 2010;29(3):255-62.
Kong, F. Y., Tao, W. D., Hao, Z. L., & Liu, M. (2010). Predictors of one-year disability and death in Chinese hospitalized women after ischemic stroke. Cerebrovascular Diseases (Basel, Switzerland), 29(3), 255-62. https://doi.org/10.1159/000267852
Kong FY, et al. Predictors of One-year Disability and Death in Chinese Hospitalized Women After Ischemic Stroke. Cerebrovasc Dis. 2010;29(3):255-62. PubMed PMID: 20029199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictors of one-year disability and death in Chinese hospitalized women after ischemic stroke. AU - Kong,Fan-Yi, AU - Tao,Wen-Dan, AU - Hao,Zi-Long, AU - Liu,Ming, Y1 - 2009/12/18/ PY - 2009/04/17/received PY - 2009/10/25/accepted PY - 2009/12/24/entrez PY - 2009/12/24/pubmed PY - 2010/3/5/medline SP - 255 EP - 62 JF - Cerebrovascular diseases (Basel, Switzerland) JO - Cerebrovasc Dis VL - 29 IS - 3 N2 - BACKGROUND AND PURPOSE: Women have a worse functional outcome after stroke, but the specific factors associated with a poor outcome in women are rarely reported. This study was designed to investigate the clinical predictors of 1-year disability and death in women after ischemic stroke. METHODS: Patients with ischemic stroke consecutively registered from March 2002 to July 2007 were followed prospectively for 1 year. Multivariate regression models were employed to analyze predictors of disability (defined as modified Rankin scale score, mRS, 3-5) and death. RESULTS: A total of 2,774 ischemic stroke patients were included with 1,119 (40.3%) females (mean age 65 +/- 13.5 years). Among female patients, disability (mRS 3-5) is 1.68-fold higher and case fatality is 1.23-fold higher than in men at the 1-year follow-up. Diabetes is an independent predictor of 1-year disability among women (odds ratio, 1.56; 95% confidence interval, CI, 1.01-2.39). In-hospital acute renal failure (hazard ratio, HR, 7.26; 95% CI, 3.47-5.19), suboptimal antiplatelets (HR, 0.55; 95% CI, 0.37-0.83) and antihypertensive therapy (HR, 0.61; 95% CI, 0.42-0.90) are associated with death at 1 year after stroke among women. CONCLUSIONS: The present study indicates that diabetes, in-hospital acute renal failure, suboptimal antiplatelets and antihypertensive therapy are the possible explanations for the poor 1-year outcome of women hospitalized with ischemic stroke. SN - 1421-9786 UR - https://www.unboundmedicine.com/medline/citation/20029199/Predictors_of_one_year_disability_and_death_in_Chinese_hospitalized_women_after_ischemic_stroke_ L2 - https://www.karger.com?DOI=10.1159/000267852 DB - PRIME DP - Unbound Medicine ER -