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Quality of life after adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled study.
Cancer. 2010 Feb 15; 116(4):830-6.C

Abstract

BACKGROUND

Adjuvant therapies for pancreatic and periampullary cancer reportedly achieve only a marginal survival benefit. In this randomized controlled trial, 120 patients with resected pancreatic or periampullary cancer received either adjuvant celiac axis infusion chemotherapy combined with radiotherapy (CAI/RT) or no adjuvant treatment. The objective of the study was to compare the quality of life (QoL) in patients who received CAI/RT after pancreatoduodenectomy with the QoL in patients who did not receive adjuvant treatment.

METHODS

During and after CAI/RT, QoL was assessed using the European Organization for Research and Treatment of Cancer QoL Questionnaire C30 every 3 months during the first 24 months after randomization.

RESULTS

Eighty-six percent of patients (n = 103) completed 1 or more questionnaires. In total, 355 questionnaires were completed. The results indicated that CAI/RT did not impair physical, emotional, or social functioning. During and after CAI/RT, patients had significantly less pain (P = .02) and less nausea and vomiting (P = .01). Overall QoL (global functioning) tended to be better (P = .08) after CAI/RT.

CONCLUSIONS

Over a period of 24 months, CAI/RT improved QoL compared with observation alone in patients with resected pancreatic and periampullary cancer. This beneficial effect of CAI/RT was most prominent in the latter half of the follow-up.

Authors+Show Affiliations

Department of Surgery, Erasmus Medical Centre, 3015 CE Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

20029974

Citation

Morak, Marjolein J M., et al. "Quality of Life After Adjuvant Intra-arterial Chemotherapy and Radiotherapy Versus Surgery Alone in Resectable Pancreatic and Periampullary Cancer: a Prospective Randomized Controlled Study." Cancer, vol. 116, no. 4, 2010, pp. 830-6.
Morak MJ, Pek CJ, Kompanje EJ, et al. Quality of life after adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled study. Cancer. 2010;116(4):830-6.
Morak, M. J., Pek, C. J., Kompanje, E. J., Hop, W. C., Kazemier, G., & van Eijck, C. H. (2010). Quality of life after adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled study. Cancer, 116(4), 830-6. https://doi.org/10.1002/cncr.24809
Morak MJ, et al. Quality of Life After Adjuvant Intra-arterial Chemotherapy and Radiotherapy Versus Surgery Alone in Resectable Pancreatic and Periampullary Cancer: a Prospective Randomized Controlled Study. Cancer. 2010 Feb 15;116(4):830-6. PubMed PMID: 20029974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quality of life after adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled study. AU - Morak,Marjolein J M, AU - Pek,Chulja J, AU - Kompanje,Erwin J O, AU - Hop,Wim C J, AU - Kazemier,Geert, AU - van Eijck,Casper H J, PY - 2009/12/24/entrez PY - 2009/12/24/pubmed PY - 2010/3/17/medline SP - 830 EP - 6 JF - Cancer JO - Cancer VL - 116 IS - 4 N2 - BACKGROUND: Adjuvant therapies for pancreatic and periampullary cancer reportedly achieve only a marginal survival benefit. In this randomized controlled trial, 120 patients with resected pancreatic or periampullary cancer received either adjuvant celiac axis infusion chemotherapy combined with radiotherapy (CAI/RT) or no adjuvant treatment. The objective of the study was to compare the quality of life (QoL) in patients who received CAI/RT after pancreatoduodenectomy with the QoL in patients who did not receive adjuvant treatment. METHODS: During and after CAI/RT, QoL was assessed using the European Organization for Research and Treatment of Cancer QoL Questionnaire C30 every 3 months during the first 24 months after randomization. RESULTS: Eighty-six percent of patients (n = 103) completed 1 or more questionnaires. In total, 355 questionnaires were completed. The results indicated that CAI/RT did not impair physical, emotional, or social functioning. During and after CAI/RT, patients had significantly less pain (P = .02) and less nausea and vomiting (P = .01). Overall QoL (global functioning) tended to be better (P = .08) after CAI/RT. CONCLUSIONS: Over a period of 24 months, CAI/RT improved QoL compared with observation alone in patients with resected pancreatic and periampullary cancer. This beneficial effect of CAI/RT was most prominent in the latter half of the follow-up. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/20029974/Quality_of_life_after_adjuvant_intra_arterial_chemotherapy_and_radiotherapy_versus_surgery_alone_in_resectable_pancreatic_and_periampullary_cancer:_a_prospective_randomized_controlled_study_ L2 - https://doi.org/10.1002/cncr.24809 DB - PRIME DP - Unbound Medicine ER -