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Promoting continuous use as a strategy for achieving adherence in a trial of the diaphragm with candidate microbicide.
AIDS Educ Prev. 2009 Dec; 21(6):512-25.AE

Abstract

Women need more choices for protection from HIV and other sexually transmitted infections (STIs). We conducted a randomized 4-week study in Madagascar in preparation for a Phase III randomized controlled trial (RCT) of the diaphragm with a candidate microbicide for STI prevention. All participants completed quantitative surveys; half participated in a qualitative interview. We advised women to wear the diaphragm at all times except for daily cleaning (rather than inserting it before intercourse). The objective of this analysis was to determine whether women who followed this "continuous use" approach more often used the diaphragm for 100% of sex acts as compared with other women. If so, this would support advising continuous diaphragm use in the upcoming RCT. To meet our objective, we analyzed qualitative data thematically, developed a measure of continuous diaphragm use based on qualitative data, and used multiple regression to evaluate the measure's association with adherence to diaphragm use during 100% of sex acts. Women who wore the diaphragm continuously had 4 times higher odds of reporting diaphragm use during 100% of sex acts (OR: 4.6, 95% CI: 1.2, 24.0). If the diaphragm proves effective against STI, continuous use may help women achieve high levels of protection.

Authors+Show Affiliations

Centers for Disease, Control and Prevention (CDC), Atlanta, GA, 30341, USA. bpv4@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

20030496

Citation

Penman-Aguilar, Ana, et al. "Promoting Continuous Use as a Strategy for Achieving Adherence in a Trial of the Diaphragm With Candidate Microbicide." AIDS Education and Prevention : Official Publication of the International Society for AIDS Education, vol. 21, no. 6, 2009, pp. 512-25.
Penman-Aguilar A, Swezey T, Turner AN, et al. Promoting continuous use as a strategy for achieving adherence in a trial of the diaphragm with candidate microbicide. AIDS Educ Prev. 2009;21(6):512-25.
Penman-Aguilar, A., Swezey, T., Turner, A. N., Bell, A. J., Ramiandrisoa, F. N., Legardy-Williams, J., Randrianasolo, B., Van Damme, K., Dulyx, J., Behets, F., & Jamieson, D. J. (2009). Promoting continuous use as a strategy for achieving adherence in a trial of the diaphragm with candidate microbicide. AIDS Education and Prevention : Official Publication of the International Society for AIDS Education, 21(6), 512-25. https://doi.org/10.1521/aeap.2009.21.6.512
Penman-Aguilar A, et al. Promoting Continuous Use as a Strategy for Achieving Adherence in a Trial of the Diaphragm With Candidate Microbicide. AIDS Educ Prev. 2009;21(6):512-25. PubMed PMID: 20030496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Promoting continuous use as a strategy for achieving adherence in a trial of the diaphragm with candidate microbicide. AU - Penman-Aguilar,Ana, AU - Swezey,Teresa, AU - Turner,Abigail Norris, AU - Bell,April J, AU - Ramiandrisoa,Felasoa Noroseheno, AU - Legardy-Williams,Jennifer, AU - Randrianasolo,Bodo, AU - Van Damme,Kathleen, AU - Dulyx,Jennifer, AU - Behets,Frieda, AU - Jamieson,Denise J, PY - 2009/12/25/entrez PY - 2009/12/25/pubmed PY - 2010/2/23/medline SP - 512 EP - 25 JF - AIDS education and prevention : official publication of the International Society for AIDS Education JO - AIDS Educ Prev VL - 21 IS - 6 N2 - Women need more choices for protection from HIV and other sexually transmitted infections (STIs). We conducted a randomized 4-week study in Madagascar in preparation for a Phase III randomized controlled trial (RCT) of the diaphragm with a candidate microbicide for STI prevention. All participants completed quantitative surveys; half participated in a qualitative interview. We advised women to wear the diaphragm at all times except for daily cleaning (rather than inserting it before intercourse). The objective of this analysis was to determine whether women who followed this "continuous use" approach more often used the diaphragm for 100% of sex acts as compared with other women. If so, this would support advising continuous diaphragm use in the upcoming RCT. To meet our objective, we analyzed qualitative data thematically, developed a measure of continuous diaphragm use based on qualitative data, and used multiple regression to evaluate the measure's association with adherence to diaphragm use during 100% of sex acts. Women who wore the diaphragm continuously had 4 times higher odds of reporting diaphragm use during 100% of sex acts (OR: 4.6, 95% CI: 1.2, 24.0). If the diaphragm proves effective against STI, continuous use may help women achieve high levels of protection. SN - 1943-2755 UR - https://www.unboundmedicine.com/medline/citation/20030496/Promoting_continuous_use_as_a_strategy_for_achieving_adherence_in_a_trial_of_the_diaphragm_with_candidate_microbicide_ L2 - https://guilfordjournals.com/doi/10.1521/aeap.2009.21.6.512 DB - PRIME DP - Unbound Medicine ER -