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Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline.
J Enzyme Inhib Med Chem. 2010 Feb; 25(1):44-53.JE

Abstract

In the present study, we determined the antioxidant activity of cepharanthine and fangchinoline from Stephania rotunda by performing different in vitro antioxidant assays, including 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging, N,N- dimethyl-p-phenylenediamine dihydrochloride (DMPD) radical scavenging, superoxide anion (O2*-) radical scavenging, hydrogen peroxide scavenging, total antioxidant activity, reducing power, and ferrous ion (Fe2+) chelating activities. Cepharanthine and fangchinoline showed 94.6 and 93.3% inhibition on lipid peroxidation of linoleic acid emulsion at 30 microg/mL concentration, respectively. On the other hand, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol, and trolox indicated inhibitions of 83.3, 92.2, 72.4, and 81.3% on peroxidation of linoleic acid emulsion at the same concentration (30 microg/mL), respectively. According to the results, cepharanthine and fangchinoline have effective antioxidant and radical scavenging activity.

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Authors+Show Affiliations

Gülçin I
Department of Chemistry, Faculty of Sciences, Atatürk University, Erzurum, Turkey. igulcin@atauni.edu.tr
Elias R
No affiliation info available
Gepdiremen A
No affiliation info available
Chea A
No affiliation info available
Topal F
No affiliation info available

MeSH

AntioxidantsBenzylisoquinolinesButylated HydroxyanisoleButylated HydroxytolueneChromansLipid PeroxidationStephaniaalpha-Tocopherol

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20030508

Citation

Gülçin, Ilhami, et al. "Antioxidant Activity of Bisbenzylisoquinoline Alkaloids From Stephania Rotunda: Cepharanthine and Fangchinoline." Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 25, no. 1, 2010, pp. 44-53.
Gülçin I, Elias R, Gepdiremen A, et al. Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline. J Enzyme Inhib Med Chem. 2010;25(1):44-53.
Gülçin, I., Elias, R., Gepdiremen, A., Chea, A., & Topal, F. (2010). Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline. Journal of Enzyme Inhibition and Medicinal Chemistry, 25(1), 44-53. https://doi.org/10.3109/14756360902932792
Gülçin I, et al. Antioxidant Activity of Bisbenzylisoquinoline Alkaloids From Stephania Rotunda: Cepharanthine and Fangchinoline. J Enzyme Inhib Med Chem. 2010;25(1):44-53. PubMed PMID: 20030508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline. AU - Gülçin,Ilhami, AU - Elias,Riad, AU - Gepdiremen,Akçahan, AU - Chea,Aun, AU - Topal,Fevzi, PY - 2009/12/25/entrez PY - 2009/12/25/pubmed PY - 2010/4/9/medline SP - 44 EP - 53 JF - Journal of enzyme inhibition and medicinal chemistry JO - J Enzyme Inhib Med Chem VL - 25 IS - 1 N2 - In the present study, we determined the antioxidant activity of cepharanthine and fangchinoline from Stephania rotunda by performing different in vitro antioxidant assays, including 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging, N,N- dimethyl-p-phenylenediamine dihydrochloride (DMPD) radical scavenging, superoxide anion (O2*-) radical scavenging, hydrogen peroxide scavenging, total antioxidant activity, reducing power, and ferrous ion (Fe2+) chelating activities. Cepharanthine and fangchinoline showed 94.6 and 93.3% inhibition on lipid peroxidation of linoleic acid emulsion at 30 microg/mL concentration, respectively. On the other hand, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol, and trolox indicated inhibitions of 83.3, 92.2, 72.4, and 81.3% on peroxidation of linoleic acid emulsion at the same concentration (30 microg/mL), respectively. According to the results, cepharanthine and fangchinoline have effective antioxidant and radical scavenging activity. SN - 1475-6374 UR - https://www.unboundmedicine.com/medline/citation/20030508/Antioxidant_activity_of_bisbenzylisoquinoline_alkaloids_from_Stephania_rotunda:_cepharanthine_and_fangchinoline_ L2 - https://www.tandfonline.com/doi/full/10.3109/14756360902932792 DB - PRIME DP - Unbound Medicine ER -