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Maillard reaction, mitochondria and oxidative stress: potential role of antioxidants.
Pathol Biol (Paris). 2010 Jun; 58(3):220-5.PB

Abstract

Glycation and oxidative stress are two important processes known to play a key role in complications of many disease processes. Oxidative stress, either via increasing reactive oxygen species (ROS), or by depleting the antioxidants may modulate the genesis of early glycated proteins in vivo. Maillard Reactions, occur in vivo as well as in vitro and are associated with the chronic complications of diabetes, aging and age-related diseases. Hyperglycaemia causes the autoxidation of glucose, glycation of proteins, and the activation of polyol metabolism. These changes facilitate the generation of reactive oxygen species and decrease the activity of antioxidant enzymes such as Cu,Zn-superoxide dismutase, resulting in a remarkable increase of oxidative stress. A large body of evidence indicates that mitochondria alteration is involved and plays a central role in various oxidative stress-related diseases. The damaged mitochondria produce more ROS (increase oxidative stress) and less ATP (cellular energy) than normal mitochondria. As they are damaged, they cannot burn or use glucose or lipid and cannot provide cell with ATP. Further, glucose, amino acids and lipid will not be correctly used and will accumulate outside the mitochondria; they will undergo more glycation (as observed in diabetes, obesity, HIV infection and lipodystrophia). The objective of this paper is to discuss how to stop the vicious circle established between oxidative stress, Maillard Reaction and mitochondria. The potential application of some antioxidants to reduce glycation phenomenon and to increase the antioxidant defence system by targeting mitochondria will be discussed. Food and pharmaceutical companies share the same challenge, they must act now, urgently and energetically.

Authors+Show Affiliations

Société française des antioxydants, International Antioxidants Task Force, 15, rue de la Paix, 75002 Paris, France. sfa.paris@orange.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20031340

Citation

Edeas, M, et al. "Maillard Reaction, Mitochondria and Oxidative Stress: Potential Role of Antioxidants." Pathologie-biologie, vol. 58, no. 3, 2010, pp. 220-5.
Edeas M, Attaf D, Mailfert AS, et al. Maillard reaction, mitochondria and oxidative stress: potential role of antioxidants. Pathol Biol (Paris). 2010;58(3):220-5.
Edeas, M., Attaf, D., Mailfert, A. S., Nasu, M., & Joubet, R. (2010). Maillard reaction, mitochondria and oxidative stress: potential role of antioxidants. Pathologie-biologie, 58(3), 220-5. https://doi.org/10.1016/j.patbio.2009.09.011
Edeas M, et al. Maillard Reaction, Mitochondria and Oxidative Stress: Potential Role of Antioxidants. Pathol Biol (Paris). 2010;58(3):220-5. PubMed PMID: 20031340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maillard reaction, mitochondria and oxidative stress: potential role of antioxidants. AU - Edeas,M, AU - Attaf,D, AU - Mailfert,A-S, AU - Nasu,M, AU - Joubet,R, Y1 - 2009/12/23/ PY - 2009/07/17/received PY - 2009/09/14/accepted PY - 2009/12/25/entrez PY - 2009/12/25/pubmed PY - 2010/9/2/medline SP - 220 EP - 5 JF - Pathologie-biologie JO - Pathol Biol (Paris) VL - 58 IS - 3 N2 - Glycation and oxidative stress are two important processes known to play a key role in complications of many disease processes. Oxidative stress, either via increasing reactive oxygen species (ROS), or by depleting the antioxidants may modulate the genesis of early glycated proteins in vivo. Maillard Reactions, occur in vivo as well as in vitro and are associated with the chronic complications of diabetes, aging and age-related diseases. Hyperglycaemia causes the autoxidation of glucose, glycation of proteins, and the activation of polyol metabolism. These changes facilitate the generation of reactive oxygen species and decrease the activity of antioxidant enzymes such as Cu,Zn-superoxide dismutase, resulting in a remarkable increase of oxidative stress. A large body of evidence indicates that mitochondria alteration is involved and plays a central role in various oxidative stress-related diseases. The damaged mitochondria produce more ROS (increase oxidative stress) and less ATP (cellular energy) than normal mitochondria. As they are damaged, they cannot burn or use glucose or lipid and cannot provide cell with ATP. Further, glucose, amino acids and lipid will not be correctly used and will accumulate outside the mitochondria; they will undergo more glycation (as observed in diabetes, obesity, HIV infection and lipodystrophia). The objective of this paper is to discuss how to stop the vicious circle established between oxidative stress, Maillard Reaction and mitochondria. The potential application of some antioxidants to reduce glycation phenomenon and to increase the antioxidant defence system by targeting mitochondria will be discussed. Food and pharmaceutical companies share the same challenge, they must act now, urgently and energetically. SN - 1768-3114 UR - https://www.unboundmedicine.com/medline/citation/20031340/Maillard_reaction_mitochondria_and_oxidative_stress:_potential_role_of_antioxidants_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0369-8114(09)00189-8 DB - PRIME DP - Unbound Medicine ER -