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PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle.
Am J Physiol Cell Physiol 2010; 298(3):C572-9AJ

Abstract

Endurance exercise stimulates peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) expression in skeletal muscle, and forced expression of PGC-1alpha changes muscle metabolism and exercise capacity in mice. However, it is unclear if PGC-1alpha is indispensible for endurance exercise-induced metabolic and contractile adaptations in skeletal muscle. In this study, we showed that endurance exercise-induced expression of mitochondrial enzymes (cytochrome oxidase IV and cytochrome c) and increases of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31)-positive endothelial cells in skeletal muscle, but not IIb-to-IIa fiber-type transformation, were significantly attenuated in muscle-specific Pgc-1alpha knockout mice. Interestingly, voluntary running effectively restored the compromised mitochondrial integrity and superoxide dismutase 2 (SOD2) protein expression in skeletal muscle in Pgc-1alpha knockout mice. Thus, PGC-1alpha plays a functional role in endurance exercise-induced mitochondrial biogenesis and angiogenesis, but not IIb-to-IIa fiber-type transformation in mouse skeletal muscle, and the improvement of mitochondrial morphology and antioxidant defense in response to endurance exercise may occur independently of PGC-1alpha function. We conclude that PGC-1alpha is required for complete skeletal muscle adaptations induced by endurance exercise in mice.

Authors+Show Affiliations

Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20032509

Citation

Geng, Tuoyu, et al. "PGC-1alpha Plays a Functional Role in Exercise-induced Mitochondrial Biogenesis and Angiogenesis but Not Fiber-type Transformation in Mouse Skeletal Muscle." American Journal of Physiology. Cell Physiology, vol. 298, no. 3, 2010, pp. C572-9.
Geng T, Li P, Okutsu M, et al. PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle. Am J Physiol, Cell Physiol. 2010;298(3):C572-9.
Geng, T., Li, P., Okutsu, M., Yin, X., Kwek, J., Zhang, M., & Yan, Z. (2010). PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle. American Journal of Physiology. Cell Physiology, 298(3), pp. C572-9. doi:10.1152/ajpcell.00481.2009.
Geng T, et al. PGC-1alpha Plays a Functional Role in Exercise-induced Mitochondrial Biogenesis and Angiogenesis but Not Fiber-type Transformation in Mouse Skeletal Muscle. Am J Physiol, Cell Physiol. 2010;298(3):C572-9. PubMed PMID: 20032509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle. AU - Geng,Tuoyu, AU - Li,Ping, AU - Okutsu,Mitsuharu, AU - Yin,Xinhe, AU - Kwek,Jyeyi, AU - Zhang,Mei, AU - Yan,Zhen, Y1 - 2009/12/23/ PY - 2009/12/25/entrez PY - 2009/12/25/pubmed PY - 2010/4/2/medline SP - C572 EP - 9 JF - American journal of physiology. Cell physiology JO - Am. J. Physiol., Cell Physiol. VL - 298 IS - 3 N2 - Endurance exercise stimulates peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) expression in skeletal muscle, and forced expression of PGC-1alpha changes muscle metabolism and exercise capacity in mice. However, it is unclear if PGC-1alpha is indispensible for endurance exercise-induced metabolic and contractile adaptations in skeletal muscle. In this study, we showed that endurance exercise-induced expression of mitochondrial enzymes (cytochrome oxidase IV and cytochrome c) and increases of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31)-positive endothelial cells in skeletal muscle, but not IIb-to-IIa fiber-type transformation, were significantly attenuated in muscle-specific Pgc-1alpha knockout mice. Interestingly, voluntary running effectively restored the compromised mitochondrial integrity and superoxide dismutase 2 (SOD2) protein expression in skeletal muscle in Pgc-1alpha knockout mice. Thus, PGC-1alpha plays a functional role in endurance exercise-induced mitochondrial biogenesis and angiogenesis, but not IIb-to-IIa fiber-type transformation in mouse skeletal muscle, and the improvement of mitochondrial morphology and antioxidant defense in response to endurance exercise may occur independently of PGC-1alpha function. We conclude that PGC-1alpha is required for complete skeletal muscle adaptations induced by endurance exercise in mice. SN - 1522-1563 UR - https://www.unboundmedicine.com/medline/citation/20032509/PGC_1alpha_plays_a_functional_role_in_exercise_induced_mitochondrial_biogenesis_and_angiogenesis_but_not_fiber_type_transformation_in_mouse_skeletal_muscle_ L2 - http://www.physiology.org/doi/full/10.1152/ajpcell.00481.2009?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -