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Rosiglitazone ameliorates endotoxin-induced organ damage in conscious rats.
Biol Res Nurs. 2011 Jan; 13(1):38-43.BR

Abstract

Rosiglitazone is a peroxisome proliferator-activated receptor (PPAR)-γ agonist. By inhibiting nuclear factor κB (NF-κB), it decreases tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) and has an anti-inflammatory effect. Endotoxin shock can induce the production of several inflammatory mediators such as TNF-α and IL-6, leading to multiple organ dysfunction and death. We investigated the effects of rosiglitazone (.3 mg/kg, intravenous administration) on the physiologic attributes and cytokine levels in endotoxin shock in conscious rats. Endotoxin shock was induced by intravenous injection of Klebsiella pneumoniae lipopolysaccharides (LPSs; 10 mg/kg) in conscious rats. Mean arterial pressure (MAP) and heart rate (HR) were continuously monitored for 24 hr after LPS administration. Levels of biochemical and cytokine parameters, including glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), blood urea nitrogen (BUN), creatinine (Cre), lactic dehydrogenase (LDH), creatine phosphokinase (CPK), glucose, TNF-α, and IL-6 were measured at 0, 1, 3, 6, 12, and 24 hr after sepsis. Endotoxin shock significantly increased blood GOT, GPT, BUN, Cre, LDH, CPK, glucose, TNF-α, and IL-6 levels and HR, while also decreasing MAP. Rosiglitazone diminished the increase in HR, decreased the markers of organ injury (GOT, GPT, BUN, Cre, LDH, CPK, glucose) and inflammatory biomarkers (TNF-α, IL-6), and did not affect MAP after LPS. In conclusion, rosiglitazone ameliorated endotoxin shock-induced markers of organ injury and suppressed the release of TNF-α and IL-6 in conscious rats.

Authors+Show Affiliations

Institute of Medical Sciences, Tzu Chi University, No. 701 Section 3 Chung Yang Rd., Hualien, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20034949

Citation

Wu, Wen-Tien, et al. "Rosiglitazone Ameliorates Endotoxin-induced Organ Damage in Conscious Rats." Biological Research for Nursing, vol. 13, no. 1, 2011, pp. 38-43.
Wu WT, Lee CC, Lee CJ, et al. Rosiglitazone ameliorates endotoxin-induced organ damage in conscious rats. Biol Res Nurs. 2011;13(1):38-43.
Wu, W. T., Lee, C. C., Lee, C. J., Subeq, Y. M., Lee, R. P., & Hsu, B. G. (2011). Rosiglitazone ameliorates endotoxin-induced organ damage in conscious rats. Biological Research for Nursing, 13(1), 38-43. https://doi.org/10.1177/1099800409353358
Wu WT, et al. Rosiglitazone Ameliorates Endotoxin-induced Organ Damage in Conscious Rats. Biol Res Nurs. 2011;13(1):38-43. PubMed PMID: 20034949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rosiglitazone ameliorates endotoxin-induced organ damage in conscious rats. AU - Wu,Wen-Tien, AU - Lee,Chia-Chi, AU - Lee,Chung-Jen, AU - Subeq,Yi-Maun, AU - Lee,Ru-Ping, AU - Hsu,Bang-Gee, Y1 - 2009/12/23/ PY - 2009/12/26/entrez PY - 2009/12/26/pubmed PY - 2011/4/26/medline SP - 38 EP - 43 JF - Biological research for nursing JO - Biol Res Nurs VL - 13 IS - 1 N2 - Rosiglitazone is a peroxisome proliferator-activated receptor (PPAR)-γ agonist. By inhibiting nuclear factor κB (NF-κB), it decreases tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) and has an anti-inflammatory effect. Endotoxin shock can induce the production of several inflammatory mediators such as TNF-α and IL-6, leading to multiple organ dysfunction and death. We investigated the effects of rosiglitazone (.3 mg/kg, intravenous administration) on the physiologic attributes and cytokine levels in endotoxin shock in conscious rats. Endotoxin shock was induced by intravenous injection of Klebsiella pneumoniae lipopolysaccharides (LPSs; 10 mg/kg) in conscious rats. Mean arterial pressure (MAP) and heart rate (HR) were continuously monitored for 24 hr after LPS administration. Levels of biochemical and cytokine parameters, including glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), blood urea nitrogen (BUN), creatinine (Cre), lactic dehydrogenase (LDH), creatine phosphokinase (CPK), glucose, TNF-α, and IL-6 were measured at 0, 1, 3, 6, 12, and 24 hr after sepsis. Endotoxin shock significantly increased blood GOT, GPT, BUN, Cre, LDH, CPK, glucose, TNF-α, and IL-6 levels and HR, while also decreasing MAP. Rosiglitazone diminished the increase in HR, decreased the markers of organ injury (GOT, GPT, BUN, Cre, LDH, CPK, glucose) and inflammatory biomarkers (TNF-α, IL-6), and did not affect MAP after LPS. In conclusion, rosiglitazone ameliorated endotoxin shock-induced markers of organ injury and suppressed the release of TNF-α and IL-6 in conscious rats. SN - 1552-4175 UR - https://www.unboundmedicine.com/medline/citation/20034949/Rosiglitazone_ameliorates_endotoxin_induced_organ_damage_in_conscious_rats_ L2 - https://journals.sagepub.com/doi/10.1177/1099800409353358?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -