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Stability of cefazolin sodium in peritoneal dialysis solutions.
Am J Hosp Pharm. 1991 Feb; 48(2):291-2.AJ

Abstract

The stability of cefazolin sodium was studied in two commonly used peritoneal dialysis solutions. Cefazolin (as the sodium salt) 250 mg was added to 500-mL bags of dialysis solution containing 1.5% or 4.25% dextrose injection to yield a target concentration of 0.5 mg/mL. Of 18 bags containing 1.5% dextrose injection, six were stored at 4 degrees C, six at 25 degrees C, and six at 37 degrees C. Similarly, of 18 bags containing 4.25% dextrose injection, groups of six were stored at each temperature. Samples were measured for cefazolin concentration by high-performance liquid chromatography at 0, 3, 7, 10, and 14 days for solutions stored at 4 degrees C; 0, 1, 2, 3, 8, and 11 days for solutions stored at 25 degrees C; and 0, 6, 12, and 24 hours for solutions stored at 37 degrees C. The cefazolin concentration in both solutions was greater than or equal to 90% of the initial concentration for 14 days at 4 degrees C, 8 days at 25 degrees C, and 1 day at 37 degrees C. On day 11 at 25 degrees C, however, the loss of cefazolin was 11% for the solution containing 1.5% dextrose injection and 15% for the 4.25% dextrose injection. The sterility of the solutions was not determined. Cefazolin sodium was stable in peritoneal dialysis solutions containing 1.5% and 4.24% dextrose injection for 14 days at 4 degrees C, 8 days at 25 degrees C, and 24 hours at 37 degrees C.

Authors+Show Affiliations

College of Pharmacy, Ohio State University, Columbus 43210.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2003503

Citation

Nahata, M C., and P A. Ahalt. "Stability of Cefazolin Sodium in Peritoneal Dialysis Solutions." American Journal of Hospital Pharmacy, vol. 48, no. 2, 1991, pp. 291-2.
Nahata MC, Ahalt PA. Stability of cefazolin sodium in peritoneal dialysis solutions. Am J Hosp Pharm. 1991;48(2):291-2.
Nahata, M. C., & Ahalt, P. A. (1991). Stability of cefazolin sodium in peritoneal dialysis solutions. American Journal of Hospital Pharmacy, 48(2), 291-2.
Nahata MC, Ahalt PA. Stability of Cefazolin Sodium in Peritoneal Dialysis Solutions. Am J Hosp Pharm. 1991;48(2):291-2. PubMed PMID: 2003503.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stability of cefazolin sodium in peritoneal dialysis solutions. AU - Nahata,M C, AU - Ahalt,P A, PY - 1991/2/1/pubmed PY - 1991/2/1/medline PY - 1991/2/1/entrez SP - 291 EP - 2 JF - American journal of hospital pharmacy JO - Am J Hosp Pharm VL - 48 IS - 2 N2 - The stability of cefazolin sodium was studied in two commonly used peritoneal dialysis solutions. Cefazolin (as the sodium salt) 250 mg was added to 500-mL bags of dialysis solution containing 1.5% or 4.25% dextrose injection to yield a target concentration of 0.5 mg/mL. Of 18 bags containing 1.5% dextrose injection, six were stored at 4 degrees C, six at 25 degrees C, and six at 37 degrees C. Similarly, of 18 bags containing 4.25% dextrose injection, groups of six were stored at each temperature. Samples were measured for cefazolin concentration by high-performance liquid chromatography at 0, 3, 7, 10, and 14 days for solutions stored at 4 degrees C; 0, 1, 2, 3, 8, and 11 days for solutions stored at 25 degrees C; and 0, 6, 12, and 24 hours for solutions stored at 37 degrees C. The cefazolin concentration in both solutions was greater than or equal to 90% of the initial concentration for 14 days at 4 degrees C, 8 days at 25 degrees C, and 1 day at 37 degrees C. On day 11 at 25 degrees C, however, the loss of cefazolin was 11% for the solution containing 1.5% dextrose injection and 15% for the 4.25% dextrose injection. The sterility of the solutions was not determined. Cefazolin sodium was stable in peritoneal dialysis solutions containing 1.5% and 4.24% dextrose injection for 14 days at 4 degrees C, 8 days at 25 degrees C, and 24 hours at 37 degrees C. SN - 0002-9289 UR - https://www.unboundmedicine.com/medline/citation/2003503/Stability_of_cefazolin_sodium_in_peritoneal_dialysis_solutions_ DB - PRIME DP - Unbound Medicine ER -
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