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Trauma exposure in relation to basal salivary cortisol and the hormone response to the dexamethasone/CRH test in male railway employees without lifetime psychopathology.
Psychoneuroendocrinology. 2010 Jul; 35(6):878-86.P

Abstract

BACKGROUND

Dysregulation of the hypothalamic-pituitary-adrenal (HPA)-axis is hypothesized to underlie stress-related psychiatric disorders such as post-traumatic stress disorder (PTSD). We aimed to explore whether trauma exposure is associated with alterations in HPA-axis functioning in the absence of lifetime psychiatric morbidity.

METHOD

We included 39 trauma-exposed healthy male subjects (mean age=47 years; SD=9.2) and 24 non-exposed healthy male controls (mean age=47.4 years; SD=14.5). All subjects were free of lifetime psychopathology. Basal salivary cortisol levels (on two consecutive days) as well as the cortisol and adrenocorticotropic hormone (ACTH) response to the combined dexamethasone/corticotropin releasing hormone (Dex/CRH) challenge test were analyzed using general linear models (GLM) adjusted for body mass index, age and smoking status.

RESULTS

A blunted salivary cortisol awakening response was found in the exposed group compared to the non-exposed group (F(1,57)=5.46, p=.02). Consistent with these findings, salivary diurnal cortisol was lower in the trauma-exposed versus non-exposed group (F(1,57)=4.04, p=.05). No differences, however, were found between both groups for plasma cortisol or ACTH responses to the Dex/CRH test.

CONCLUSION

Low basal cortisol levels were found in trauma-exposed men, suggesting that HPA-axis alterations in men are associated with trauma exposure during adulthood, also in the absence of psychopathology.

Authors+Show Affiliations

Department of Psychiatry, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands. E.R.Klaassens@lumc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20036072

Citation

Klaassens, Ellen R., et al. "Trauma Exposure in Relation to Basal Salivary Cortisol and the Hormone Response to the dexamethasone/CRH Test in Male Railway Employees Without Lifetime Psychopathology." Psychoneuroendocrinology, vol. 35, no. 6, 2010, pp. 878-86.
Klaassens ER, Giltay EJ, van Veen T, et al. Trauma exposure in relation to basal salivary cortisol and the hormone response to the dexamethasone/CRH test in male railway employees without lifetime psychopathology. Psychoneuroendocrinology. 2010;35(6):878-86.
Klaassens, E. R., Giltay, E. J., van Veen, T., Veen, G., & Zitman, F. G. (2010). Trauma exposure in relation to basal salivary cortisol and the hormone response to the dexamethasone/CRH test in male railway employees without lifetime psychopathology. Psychoneuroendocrinology, 35(6), 878-86. https://doi.org/10.1016/j.psyneuen.2009.11.012
Klaassens ER, et al. Trauma Exposure in Relation to Basal Salivary Cortisol and the Hormone Response to the dexamethasone/CRH Test in Male Railway Employees Without Lifetime Psychopathology. Psychoneuroendocrinology. 2010;35(6):878-86. PubMed PMID: 20036072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trauma exposure in relation to basal salivary cortisol and the hormone response to the dexamethasone/CRH test in male railway employees without lifetime psychopathology. AU - Klaassens,Ellen R, AU - Giltay,Erik J, AU - van Veen,Tineke, AU - Veen,Gerthe, AU - Zitman,Frans G, Y1 - 2009/12/24/ PY - 2009/09/01/received PY - 2009/11/29/revised PY - 2009/11/30/accepted PY - 2009/12/29/entrez PY - 2009/12/29/pubmed PY - 2010/9/8/medline SP - 878 EP - 86 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 35 IS - 6 N2 - BACKGROUND: Dysregulation of the hypothalamic-pituitary-adrenal (HPA)-axis is hypothesized to underlie stress-related psychiatric disorders such as post-traumatic stress disorder (PTSD). We aimed to explore whether trauma exposure is associated with alterations in HPA-axis functioning in the absence of lifetime psychiatric morbidity. METHOD: We included 39 trauma-exposed healthy male subjects (mean age=47 years; SD=9.2) and 24 non-exposed healthy male controls (mean age=47.4 years; SD=14.5). All subjects were free of lifetime psychopathology. Basal salivary cortisol levels (on two consecutive days) as well as the cortisol and adrenocorticotropic hormone (ACTH) response to the combined dexamethasone/corticotropin releasing hormone (Dex/CRH) challenge test were analyzed using general linear models (GLM) adjusted for body mass index, age and smoking status. RESULTS: A blunted salivary cortisol awakening response was found in the exposed group compared to the non-exposed group (F(1,57)=5.46, p=.02). Consistent with these findings, salivary diurnal cortisol was lower in the trauma-exposed versus non-exposed group (F(1,57)=4.04, p=.05). No differences, however, were found between both groups for plasma cortisol or ACTH responses to the Dex/CRH test. CONCLUSION: Low basal cortisol levels were found in trauma-exposed men, suggesting that HPA-axis alterations in men are associated with trauma exposure during adulthood, also in the absence of psychopathology. SN - 1873-3360 UR - https://www.unboundmedicine.com/medline/citation/20036072/Trauma_exposure_in_relation_to_basal_salivary_cortisol_and_the_hormone_response_to_the_dexamethasone/CRH_test_in_male_railway_employees_without_lifetime_psychopathology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(09)00355-2 DB - PRIME DP - Unbound Medicine ER -