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Antivenomics and venom phenotyping: A marriage of convenience to address the performance and range of clinical use of antivenoms.
Toxicon. 2010 Dec 15; 56(7):1284-91.T

Abstract

Toxins from the same protein family present in venoms from snakes belonging to different genera often share antigenic determinants. A practical consequence of this circumstance is that it might be possible to formulate on an immunologically sound basis a mixture of venoms for generating antivenoms against a wide range of species. A deep insight into the inter- and intraspecific variation of the antigenic constituents of venoms from snakes of different geographic origin represents the key for designing novel polyvalent pan-generic antivenoms. This review illustrates how proteomic protocols ('venomics' and 'antivenomics') can aid in assessing the crossreactivity of antivenoms against homologous and heterologous venoms, establishing thus the range of clinical application. Recent work showing how the knowledge of evolutionary trends along with venom phenotyping may have an impact in designing a mixture of venoms for immunization aimed to produce a pan-American anti-crotalic antivenom is discussed.

Authors+Show Affiliations

Laboratorio de Proteinómica Estructural, Instituto de Biomedicina de Valencia, CSIC, Jaime Roig 11, 46010 Valencia, Spain. jcalvete@ibv.csic.es

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20036274

Citation

Calvete, Juan J.. "Antivenomics and Venom Phenotyping: a Marriage of Convenience to Address the Performance and Range of Clinical Use of Antivenoms." Toxicon : Official Journal of the International Society On Toxinology, vol. 56, no. 7, 2010, pp. 1284-91.
Calvete JJ. Antivenomics and venom phenotyping: A marriage of convenience to address the performance and range of clinical use of antivenoms. Toxicon. 2010;56(7):1284-91.
Calvete, J. J. (2010). Antivenomics and venom phenotyping: A marriage of convenience to address the performance and range of clinical use of antivenoms. Toxicon : Official Journal of the International Society On Toxinology, 56(7), 1284-91. https://doi.org/10.1016/j.toxicon.2009.12.015
Calvete JJ. Antivenomics and Venom Phenotyping: a Marriage of Convenience to Address the Performance and Range of Clinical Use of Antivenoms. Toxicon. 2010 Dec 15;56(7):1284-91. PubMed PMID: 20036274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antivenomics and venom phenotyping: A marriage of convenience to address the performance and range of clinical use of antivenoms. A1 - Calvete,Juan J, Y1 - 2009/12/29/ PY - 2009/10/24/received PY - 2009/12/17/accepted PY - 2009/12/29/entrez PY - 2009/12/29/pubmed PY - 2011/7/14/medline SP - 1284 EP - 91 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 56 IS - 7 N2 - Toxins from the same protein family present in venoms from snakes belonging to different genera often share antigenic determinants. A practical consequence of this circumstance is that it might be possible to formulate on an immunologically sound basis a mixture of venoms for generating antivenoms against a wide range of species. A deep insight into the inter- and intraspecific variation of the antigenic constituents of venoms from snakes of different geographic origin represents the key for designing novel polyvalent pan-generic antivenoms. This review illustrates how proteomic protocols ('venomics' and 'antivenomics') can aid in assessing the crossreactivity of antivenoms against homologous and heterologous venoms, establishing thus the range of clinical application. Recent work showing how the knowledge of evolutionary trends along with venom phenotyping may have an impact in designing a mixture of venoms for immunization aimed to produce a pan-American anti-crotalic antivenom is discussed. SN - 1879-3150 UR - https://www.unboundmedicine.com/medline/citation/20036274/Antivenomics_and_venom_phenotyping:_A_marriage_of_convenience_to_address_the_performance_and_range_of_clinical_use_of_antivenoms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(09)00584-4 DB - PRIME DP - Unbound Medicine ER -