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Antioxidant, free radical scavenging activities of Salvia brachyantha and its protective effect against oxidative cardiac cell injury.
Food Chem Toxicol. 2010 Mar; 48(3):846-53.FC

Abstract

In this study, antioxidant and free radical scavenging activities of an endemic Salvia species (Salvia brachyantha (Bordz) probed. was assessed in vitro using 1,1-diphenyl-2-picryhydrazyl (DPPH) radical, beta-carotene linoleic acid, superoxide anion radical, hydroxyl radical, and reducing power assays. Regarding our data, the plant extract exhibited antioxidant and radical scavenging activities at different magnitudes of potency. In addition, this study was undertaken to assess whether methanol extract of S. brachyantha could increase the endogenous antioxidant enzymes in cells, and where such increased cellular defences could provide protection against oxidative cell injury. Pre treatment of rat heart cell lines with 100 microg/ml of plant extract for 24h significantly prevented cell damage and enhanced activity of antioxidant enzymes induced by a treatment with xanthine/xanthine oxidase. Increased reactive oxygen species and cell apoptosis induced by xanthine/xanthine oxidase was dose-dependently prevented when cells were pre treated for 24h with plant extract. These results indicated that S. brachyantha could protect against cell injury via induction of the antioxidant enzyme defences. The extract of this plant might be valuable antioxidant natural sources and seemed to be applicable in both healthy medicine and food industry.

Authors+Show Affiliations

Department of Biology, Medicinal Plants and Drug Research Institute, Shahid Beheshti University GC, Tehran, Iran. m_esmaeili@sbu.ac.irNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20036303

Citation

Esmaeili, Mohammad Ali, and Ali Sonboli. "Antioxidant, Free Radical Scavenging Activities of Salvia Brachyantha and Its Protective Effect Against Oxidative Cardiac Cell Injury." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 48, no. 3, 2010, pp. 846-53.
Esmaeili MA, Sonboli A. Antioxidant, free radical scavenging activities of Salvia brachyantha and its protective effect against oxidative cardiac cell injury. Food Chem Toxicol. 2010;48(3):846-53.
Esmaeili, M. A., & Sonboli, A. (2010). Antioxidant, free radical scavenging activities of Salvia brachyantha and its protective effect against oxidative cardiac cell injury. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 48(3), 846-53. https://doi.org/10.1016/j.fct.2009.12.020
Esmaeili MA, Sonboli A. Antioxidant, Free Radical Scavenging Activities of Salvia Brachyantha and Its Protective Effect Against Oxidative Cardiac Cell Injury. Food Chem Toxicol. 2010;48(3):846-53. PubMed PMID: 20036303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant, free radical scavenging activities of Salvia brachyantha and its protective effect against oxidative cardiac cell injury. AU - Esmaeili,Mohammad Ali, AU - Sonboli,Ali, Y1 - 2009/12/28/ PY - 2009/09/23/received PY - 2009/11/26/revised PY - 2009/12/21/accepted PY - 2009/12/29/entrez PY - 2009/12/29/pubmed PY - 2010/6/3/medline SP - 846 EP - 53 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 48 IS - 3 N2 - In this study, antioxidant and free radical scavenging activities of an endemic Salvia species (Salvia brachyantha (Bordz) probed. was assessed in vitro using 1,1-diphenyl-2-picryhydrazyl (DPPH) radical, beta-carotene linoleic acid, superoxide anion radical, hydroxyl radical, and reducing power assays. Regarding our data, the plant extract exhibited antioxidant and radical scavenging activities at different magnitudes of potency. In addition, this study was undertaken to assess whether methanol extract of S. brachyantha could increase the endogenous antioxidant enzymes in cells, and where such increased cellular defences could provide protection against oxidative cell injury. Pre treatment of rat heart cell lines with 100 microg/ml of plant extract for 24h significantly prevented cell damage and enhanced activity of antioxidant enzymes induced by a treatment with xanthine/xanthine oxidase. Increased reactive oxygen species and cell apoptosis induced by xanthine/xanthine oxidase was dose-dependently prevented when cells were pre treated for 24h with plant extract. These results indicated that S. brachyantha could protect against cell injury via induction of the antioxidant enzyme defences. The extract of this plant might be valuable antioxidant natural sources and seemed to be applicable in both healthy medicine and food industry. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/20036303/Antioxidant_free_radical_scavenging_activities_of_Salvia_brachyantha_and_its_protective_effect_against_oxidative_cardiac_cell_injury_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(09)00602-4 DB - PRIME DP - Unbound Medicine ER -