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Maternal plasma cytokines concentrations and insulin resistance in first trimester in relation to fetal growth.
Neuro Endocrinol Lett 2009; 30(6):729-32NE

Abstract

OBJECTIVE

Fetal growth is determined by genetic factors and placental supply. There is evidence that insulin might contribute to the up-regulation of placental transporter activity. The dysregulation of adiponectin and leptin is found in insulin resistance. The objective of this study was to evaluate the relation of maternal plasma cytokine and insulin concentrations in the first trimester of pregnancy to fetal growth.

METHODS

55 women with singleton pregnancy, between 12th and 14th weeks of gestation, were included to the study. Plasma concentrations of adiponectin, leptin, insulin and glucose were analyzed together with fetal ultrasound measurements and neonatal birth weight. The HOMA-IR were calculated (fasting insulin (microU/ml) x fasting glucose (mmol/l/22.5) to assess the insulin sensitivity.

RESULTS

Mean concentrations of adiponectin, leptin and insulin were 15.29 +/- 13.83 microg/ml, 6.93+/-5.39 ng/ml and 43.59+/-26.28, respectively. The average insulin resistance defined by HOMA-IR was 1.35+/-0.8. The ratios of adiponectin to leptin, adiponectin to insulin and HOMA-IR were calculated. The percentiles of fetal crown-rump length (CRL) were negatively correlated with adiponectin plasma concentration (r=-0.32; p<0.05), with no relation to leptin and insulin plasma concentration. Correlations between fetus CRL percentile and the ratio of adiponectin to leptin concentration (r=-0.37; p<0.02) and adiponectin to HOMA-IR (r=0.35; p<0.05) were also observed. No association between adiponectin, leptin, fasting insulin, HOMA-IR and neonatal birth weight or birth weight percentile was found. The percentile of fetal CRL in the 1st trimester was positively correlated with neonatal birth weight percentile (r=0.3; p<0.05).

CONCLUSIONS

The results of this study imply that maternal adiponectin concentration may play a role in early determination of fetal growth.

Authors+Show Affiliations

1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20038928

Citation

Bomba-Opon, Dorota A., et al. "Maternal Plasma Cytokines Concentrations and Insulin Resistance in First Trimester in Relation to Fetal Growth." Neuro Endocrinology Letters, vol. 30, no. 6, 2009, pp. 729-32.
Bomba-Opon DA, Wielgos M, Horosz E, et al. Maternal plasma cytokines concentrations and insulin resistance in first trimester in relation to fetal growth. Neuro Endocrinol Lett. 2009;30(6):729-32.
Bomba-Opon, D. A., Wielgos, M., Horosz, E., Bartkowiak, R., Szymusik, I., Mazanowski, N., & Bochenska, K. (2009). Maternal plasma cytokines concentrations and insulin resistance in first trimester in relation to fetal growth. Neuro Endocrinology Letters, 30(6), pp. 729-32.
Bomba-Opon DA, et al. Maternal Plasma Cytokines Concentrations and Insulin Resistance in First Trimester in Relation to Fetal Growth. Neuro Endocrinol Lett. 2009;30(6):729-32. PubMed PMID: 20038928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal plasma cytokines concentrations and insulin resistance in first trimester in relation to fetal growth. AU - Bomba-Opon,Dorota A, AU - Wielgos,Miroslaw, AU - Horosz,Edyta, AU - Bartkowiak,Robert, AU - Szymusik,Iwona, AU - Mazanowski,Natalia, AU - Bochenska,Katarzyna, PY - 2009/10/30/received PY - 2009/11/25/accepted PY - 2009/12/30/entrez PY - 2009/12/30/pubmed PY - 2010/4/1/medline SP - 729 EP - 32 JF - Neuro endocrinology letters JO - Neuro Endocrinol. Lett. VL - 30 IS - 6 N2 - OBJECTIVE: Fetal growth is determined by genetic factors and placental supply. There is evidence that insulin might contribute to the up-regulation of placental transporter activity. The dysregulation of adiponectin and leptin is found in insulin resistance. The objective of this study was to evaluate the relation of maternal plasma cytokine and insulin concentrations in the first trimester of pregnancy to fetal growth. METHODS: 55 women with singleton pregnancy, between 12th and 14th weeks of gestation, were included to the study. Plasma concentrations of adiponectin, leptin, insulin and glucose were analyzed together with fetal ultrasound measurements and neonatal birth weight. The HOMA-IR were calculated (fasting insulin (microU/ml) x fasting glucose (mmol/l/22.5) to assess the insulin sensitivity. RESULTS: Mean concentrations of adiponectin, leptin and insulin were 15.29 +/- 13.83 microg/ml, 6.93+/-5.39 ng/ml and 43.59+/-26.28, respectively. The average insulin resistance defined by HOMA-IR was 1.35+/-0.8. The ratios of adiponectin to leptin, adiponectin to insulin and HOMA-IR were calculated. The percentiles of fetal crown-rump length (CRL) were negatively correlated with adiponectin plasma concentration (r=-0.32; p<0.05), with no relation to leptin and insulin plasma concentration. Correlations between fetus CRL percentile and the ratio of adiponectin to leptin concentration (r=-0.37; p<0.02) and adiponectin to HOMA-IR (r=0.35; p<0.05) were also observed. No association between adiponectin, leptin, fasting insulin, HOMA-IR and neonatal birth weight or birth weight percentile was found. The percentile of fetal CRL in the 1st trimester was positively correlated with neonatal birth weight percentile (r=0.3; p<0.05). CONCLUSIONS: The results of this study imply that maternal adiponectin concentration may play a role in early determination of fetal growth. SN - 0172-780X UR - https://www.unboundmedicine.com/medline/citation/20038928/Maternal_plasma_cytokines_concentrations_and_insulin_resistance_in_first_trimester_in_relation_to_fetal_growth_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -