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A hospital-based case-control study of identifying ovarian cancer using symptom index.
J Gynecol Oncol. 2009 Dec; 20(4):238-42.JG

Abstract

OBJECTIVE

Recently, a symptom index for identification of ovarian cancer, based on specific symptoms along with their frequency and duration, was proposed. The current study aimed at validation of this index in Korean population.

METHODS

A case-control study of 116 women with epithelial ovarian cancer and 209 control women was conducted using questionnaires on eight symptoms. These included pelvic/abdominal pain, urinary urgency/frequency, increased abdominal size/bloating, difficulty eating/feeling full. The symptom index was considered positive if any of the 8 symptoms present for <1 year that occurred >12 times per month. The symptoms were compared between ovarian cancer group and control group using chi-square test. Logistic regression analysis was used to determine whether the index predicted cancer. Sensitivity and specificity of the symptom index were also determined.

RESULTS

The symptom index was positive in 65.5% of women with ovarian cancer, in 31.1% of women with benign cysts, and in 6.7% of women on routine screening (ps<0.001). Significantly higher proportion of ovarian cancer patients were positive for each symptom as compared with control group (ps<0.001). Results from the logistic regression indicated that the symptom index independently predicted cancer (p<0.001; OR, 10.51; 95% CI, 6.14 to 17.98). Overall, the sensitivity and specificity of the symptom index were 65.5% and 84.7%, respectively. Analyses of sensitivity by stage showed that the index was positive in 44.8% of patients with stage I/II disease and in 72.9% of patients with stage III/IV disease.

CONCLUSION

The current study supported previous studies suggesting that specific symptoms were useful in identifying women with ovarian cancer.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20041101

Citation

Kim, Mi-Kyung, et al. "A Hospital-based Case-control Study of Identifying Ovarian Cancer Using Symptom Index." Journal of Gynecologic Oncology, vol. 20, no. 4, 2009, pp. 238-42.
Kim MK, Kim K, Kim SM, et al. A hospital-based case-control study of identifying ovarian cancer using symptom index. J Gynecol Oncol. 2009;20(4):238-42.
Kim, M. K., Kim, K., Kim, S. M., Kim, J. W., Park, N. H., Song, Y. S., & Kang, S. B. (2009). A hospital-based case-control study of identifying ovarian cancer using symptom index. Journal of Gynecologic Oncology, 20(4), 238-42. https://doi.org/10.3802/jgo.2009.20.4.238
Kim MK, et al. A Hospital-based Case-control Study of Identifying Ovarian Cancer Using Symptom Index. J Gynecol Oncol. 2009;20(4):238-42. PubMed PMID: 20041101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A hospital-based case-control study of identifying ovarian cancer using symptom index. AU - Kim,Mi-Kyung, AU - Kim,Kidong, AU - Kim,Sun Min, AU - Kim,Jae Weon, AU - Park,Noh-Hyun, AU - Song,Yong-Sang, AU - Kang,Soon-Beom, Y1 - 2009/12/28/ PY - 2009/10/21/received PY - 2009/12/03/revised PY - 2009/12/10/accepted PY - 2009/12/31/entrez PY - 2009/12/31/pubmed PY - 2009/12/31/medline KW - Case-control study KW - Early diagnosis KW - Ovarian cancer KW - Symptoms SP - 238 EP - 42 JF - Journal of gynecologic oncology JO - J Gynecol Oncol VL - 20 IS - 4 N2 - OBJECTIVE: Recently, a symptom index for identification of ovarian cancer, based on specific symptoms along with their frequency and duration, was proposed. The current study aimed at validation of this index in Korean population. METHODS: A case-control study of 116 women with epithelial ovarian cancer and 209 control women was conducted using questionnaires on eight symptoms. These included pelvic/abdominal pain, urinary urgency/frequency, increased abdominal size/bloating, difficulty eating/feeling full. The symptom index was considered positive if any of the 8 symptoms present for <1 year that occurred >12 times per month. The symptoms were compared between ovarian cancer group and control group using chi-square test. Logistic regression analysis was used to determine whether the index predicted cancer. Sensitivity and specificity of the symptom index were also determined. RESULTS: The symptom index was positive in 65.5% of women with ovarian cancer, in 31.1% of women with benign cysts, and in 6.7% of women on routine screening (ps<0.001). Significantly higher proportion of ovarian cancer patients were positive for each symptom as compared with control group (ps<0.001). Results from the logistic regression indicated that the symptom index independently predicted cancer (p<0.001; OR, 10.51; 95% CI, 6.14 to 17.98). Overall, the sensitivity and specificity of the symptom index were 65.5% and 84.7%, respectively. Analyses of sensitivity by stage showed that the index was positive in 44.8% of patients with stage I/II disease and in 72.9% of patients with stage III/IV disease. CONCLUSION: The current study supported previous studies suggesting that specific symptoms were useful in identifying women with ovarian cancer. SN - 2005-0399 UR - https://www.unboundmedicine.com/medline/citation/20041101/A_hospital_based_case_control_study_of_identifying_ovarian_cancer_using_symptom_index_ L2 - https://www.ejgo.org/DOIx.php?id=10.3802/jgo.2009.20.4.238 DB - PRIME DP - Unbound Medicine ER -
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